FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100421927> ?p ?o ?g. }

• W2100421927 endingPage "509" @default.
• W2100421927 startingPage "501" @default.
• W2100421927 abstract "Several vaccines have been investigated experimentally in the herpes simplex virus type 2 (HSV-2) model system. While it is believed that CD4(+)-T-cell responses are important for protection in general, the correlates of protection from HSV-2 infection are still under investigation. Recently, the use of molecular adjuvants to drive vaccine responses induced by DNA vaccines has been reported in a number of experimental systems. We sought to take advantage of this immunization model to gain insight into the correlates of immune protection in the HSV-2 mouse model system and to further explore DNA vaccine technology. To investigate whether the Th1- or Th2-type immune responses are more important for protection from HSV-2 infection, we codelivered the DNA expression construct encoding the HSV-2 gD protein with the gene plasmids encoding the Th1-type (interleukin-2 [IL-2], IL-12, IL-15, and IL-18) and Th2-type (IL-4 and IL-10) cytokines in an effort to drive immunity induced by vaccination. We then analyzed the modulatory effects of the vaccine on the resulting immune phenotype and on the mortality and the morbidity of the immunized animals following a lethal challenge with HSV-2. We observed that Th1 cytokine gene coadministration not only enhanced the survival rate but also reduced the frequency and severity of herpetic lesions following intravaginal HSV challenge. On the other hand, coinjection with Th2 cytokine genes increased the rate of mortality and morbidity of the challenged mice. Moreover, of the Th1-type cytokine genes tested, IL-12 was a particularly potent adjuvant for the gD DNA vaccination." @default.
• W2100421927 created "2016-06-24" @default.
• W2100421927 creator A5005684865 @default.
• W2100421927 creator A5023265367 @default.
• W2100421927 creator A5062244535 @default.
• W2100421927 creator A5064644547 @default.
• W2100421927 creator A5067843924 @default.
• W2100421927 creator A5089343474 @default.
• W2100421927 date "1999-01-01" @default.
• W2100421927 modified "2023-10-14" @default.
• W2100421927 title "In Vivo Modulation of Vaccine-Induced Immune Responses toward a Th1 Phenotype Increases Potency and Vaccine Effectiveness in a Herpes Simplex Virus Type 2 Mouse Model" @default.
• W2100421927 cites W1513969932 @default.
• W2100421927 cites W1514549604 @default.
• W2100421927 cites W1523599256 @default.
• W2100421927 cites W1529453182 @default.
• W2100421927 cites W1535364173 @default.
• W2100421927 cites W1562140960 @default.
• W2100421927 cites W1581613819 @default.
• W2100421927 cites W1596798793 @default.
• W2100421927 cites W1660413876 @default.
• W2100421927 cites W1663232976 @default.
• W2100421927 cites W1816378110 @default.
• W2100421927 cites W1861344368 @default.
• W2100421927 cites W1927054599 @default.
• W2100421927 cites W1930066950 @default.
• W2100421927 cites W1960022852 @default.
• W2100421927 cites W1968942150 @default.
• W2100421927 cites W1970193565 @default.
• W2100421927 cites W1974105019 @default.
• W2100421927 cites W1975047479 @default.
• W2100421927 cites W1978269811 @default.
• W2100421927 cites W1979343444 @default.
• W2100421927 cites W1980464294 @default.
• W2100421927 cites W1983709081 @default.
• W2100421927 cites W1984915036 @default.
• W2100421927 cites W1993630121 @default.
• W2100421927 cites W2004962555 @default.
• W2100421927 cites W2009551908 @default.
• W2100421927 cites W2015803883 @default.
• W2100421927 cites W2017873272 @default.
• W2100421927 cites W2017909561 @default.
• W2100421927 cites W2037061225 @default.
• W2100421927 cites W2038260086 @default.
• W2100421927 cites W2041765961 @default.
• W2100421927 cites W2048051635 @default.
• W2100421927 cites W2049326908 @default.
• W2100421927 cites W2054629245 @default.
• W2100421927 cites W2070426326 @default.
• W2100421927 cites W2072128323 @default.
• W2100421927 cites W2076885071 @default.
• W2100421927 cites W2078315929 @default.
• W2100421927 cites W2082979778 @default.
• W2100421927 cites W2084990572 @default.
• W2100421927 cites W2085550825 @default.
• W2100421927 cites W2087395692 @default.
• W2100421927 cites W2093284893 @default.
• W2100421927 cites W2102156468 @default.
• W2100421927 cites W2102365812 @default.
• W2100421927 cites W2103960320 @default.
• W2100421927 cites W2123204333 @default.
• W2100421927 cites W2125010485 @default.
• W2100421927 cites W2126795723 @default.
• W2100421927 cites W2127278205 @default.
• W2100421927 cites W2130078717 @default.
• W2100421927 cites W2131027478 @default.
• W2100421927 cites W2131243228 @default.
• W2100421927 cites W2131328157 @default.
• W2100421927 cites W2137825890 @default.
• W2100421927 cites W2139640346 @default.
• W2100421927 cites W2140612321 @default.
• W2100421927 cites W2143209582 @default.
• W2100421927 cites W2144251883 @default.
• W2100421927 cites W2161964161 @default.
• W2100421927 cites W2162144034 @default.
• W2100421927 cites W2171831396 @default.
• W2100421927 cites W2177385981 @default.
• W2100421927 cites W2191654227 @default.
• W2100421927 cites W2314255828 @default.
• W2100421927 cites W289869260 @default.
• W2100421927 cites W37310352 @default.
• W2100421927 cites W40843633 @default.
• W2100421927 cites W4313308328 @default.
• W2100421927 doi "https://doi.org/10.1128/jvi.73.1.501-509.1999" @default.
• W2100421927 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/103857" @default.
• W2100421927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9847356" @default.
• W2100421927 hasPublicationYear "1999" @default.
• W2100421927 type Work @default.
• W2100421927 sameAs 2100421927 @default.
• W2100421927 citedByCount "146" @default.
• W2100421927 countsByYear W21004219272012 @default.
• W2100421927 countsByYear W21004219272013 @default.
• W2100421927 countsByYear W21004219272014 @default.
• W2100421927 countsByYear W21004219272015 @default.
• W2100421927 countsByYear W21004219272016 @default.
• W2100421927 countsByYear W21004219272017 @default.
• W2100421927 countsByYear W21004219272018 @default.
• W2100421927 countsByYear W21004219272019 @default.
• W2100421927 countsByYear W21004219272020 @default.

• next