FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100422237> ?p ?o ?g. }

• W2100422237 endingPage "g5493" @default.
• W2100422237 startingPage "g5493" @default.
• W2100422237 abstract "To characterise failure of antibiotic treatment in primary care in the United Kingdom in four common infection classes from 1991 to 2012.Longitudinal analysis of failure rates for first line antibiotic monotherapies associated with diagnoses for upper and lower respiratory tract infections, skin and soft tissue infections, and acute otitis media.Routine primary care data from the UK Clinical Practice Research Datalink (CPRD).Adjusted rates of treatment failure defined by standardised criteria and indexed to year 1 (1991=100).From 58 million antibiotic prescriptions in CPRD, we analysed 10,967,607 monotherapy episodes for the four indications: 4,236,574 (38.6%) for upper respiratory tract infections; 3,148,947 (28.7%) for lower respiratory tract infections; 2,568,230 (23.4%) for skin and soft tissue infections; and 1,013,856 (9.2%) for acute otitis media. In 1991, the overall failure rate was 13.9% (12.0% for upper respiratory tract infections; 16.9% for lower respiratory tract infections; 12.8% for skin and soft tissue infections; and 13.9% for acute otitis media). By 2012, the overall failure rate was 15.4%, representing an increase of 12% compared with 1991 (adjusted value indexed to first year (1991) 112, 95% confidence interval 112 to 113). The highest rate was seen in lower respiratory tract infections (135, 134 to 136). While failure rates were below 20% for most commonly prescribed antibiotics (amoxicillin, phenoxymethylpenicillin (penicillin-V), and flucloxacillin), notable increases were seen for trimethoprim in the treatment of upper respiratory tract infections (from 29.2% in 1991-95 to 70.1% in 2008-12) and for ciprofloxacin (from 22.3% in 1991-95 to 30.8% in 2008-12) and cefalexin (from 22.0% in 1991-95 to 30.8% in 2008-12) in the treatment of lower respiratory tract infections. Failure rates for broad spectrum penicillins, macrolides, and flucloxacillin remained largely stable.From 1991 to 2012, more than one in 10 first line antibiotic monotherapies for the selected infections were associated with treatment failure. Overall failure rates increased by 12% over this period, with most of the increase occurring in more recent years, when antibiotic prescribing in primary care plateaued and then increased." @default.
• W2100422237 created "2016-06-24" @default.
• W2100422237 creator A5035122029 @default.
• W2100422237 creator A5041208087 @default.
• W2100422237 creator A5045232687 @default.
• W2100422237 creator A5046379039 @default.
• W2100422237 creator A5048408434 @default.
• W2100422237 creator A5055776171 @default.
• W2100422237 creator A5072290778 @default.
• W2100422237 creator A5077893105 @default.
• W2100422237 creator A5079149152 @default.
• W2100422237 date "2014-09-23" @default.
• W2100422237 modified "2023-10-17" @default.
• W2100422237 title "Antibiotic treatment failure in four common infections in UK primary care 1991-2012: longitudinal analysis" @default.
• W2100422237 cites W1506218283 @default.
• W2100422237 cites W1958003307 @default.
• W2100422237 cites W2014080210 @default.
• W2100422237 cites W2023505524 @default.
• W2100422237 cites W2108638835 @default.
• W2100422237 cites W2110595304 @default.
• W2100422237 cites W2140353364 @default.
• W2100422237 cites W2141559306 @default.
• W2100422237 cites W2142369349 @default.
• W2100422237 cites W2158264979 @default.
• W2100422237 cites W2163589808 @default.
• W2100422237 cites W2164785151 @default.
• W2100422237 cites W2166531344 @default.
• W2100422237 cites W2171609823 @default.
• W2100422237 doi "https://doi.org/10.1136/bmj.g5493" @default.
• W2100422237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25249162" @default.
• W2100422237 hasPublicationYear "2014" @default.
• W2100422237 type Work @default.
• W2100422237 sameAs 2100422237 @default.
• W2100422237 citedByCount "101" @default.
• W2100422237 countsByYear W21004222372014 @default.
• W2100422237 countsByYear W21004222372015 @default.
• W2100422237 countsByYear W21004222372016 @default.
• W2100422237 countsByYear W21004222372017 @default.
• W2100422237 countsByYear W21004222372018 @default.
• W2100422237 countsByYear W21004222372019 @default.
• W2100422237 countsByYear W21004222372020 @default.
• W2100422237 countsByYear W21004222372021 @default.
• W2100422237 countsByYear W21004222372022 @default.
• W2100422237 countsByYear W21004222372023 @default.
• W2100422237 crossrefType "journal-article" @default.
• W2100422237 hasAuthorship W2100422237A5035122029 @default.
• W2100422237 hasAuthorship W2100422237A5041208087 @default.
• W2100422237 hasAuthorship W2100422237A5045232687 @default.
• W2100422237 hasAuthorship W2100422237A5046379039 @default.
• W2100422237 hasAuthorship W2100422237A5048408434 @default.
• W2100422237 hasAuthorship W2100422237A5055776171 @default.
• W2100422237 hasAuthorship W2100422237A5072290778 @default.
• W2100422237 hasAuthorship W2100422237A5077893105 @default.
• W2100422237 hasAuthorship W2100422237A5079149152 @default.
• W2100422237 hasBestOaLocation W21004222371 @default.
• W2100422237 hasConcept C126322002 @default.
• W2100422237 hasConcept C141071460 @default.
• W2100422237 hasConcept C174802600 @default.
• W2100422237 hasConcept C2426938 @default.
• W2100422237 hasConcept C2776012195 @default.
• W2100422237 hasConcept C2776399701 @default.
• W2100422237 hasConcept C2776439223 @default.
• W2100422237 hasConcept C2778355172 @default.
• W2100422237 hasConcept C2779489039 @default.
• W2100422237 hasConcept C2779708577 @default.
• W2100422237 hasConcept C2780805593 @default.
• W2100422237 hasConcept C501593827 @default.
• W2100422237 hasConcept C523546767 @default.
• W2100422237 hasConcept C534529494 @default.
• W2100422237 hasConcept C54355233 @default.
• W2100422237 hasConcept C71924100 @default.
• W2100422237 hasConcept C86803240 @default.
• W2100422237 hasConcept C89423630 @default.
• W2100422237 hasConcept C98274493 @default.
• W2100422237 hasConceptScore W2100422237C126322002 @default.
• W2100422237 hasConceptScore W2100422237C141071460 @default.
• W2100422237 hasConceptScore W2100422237C174802600 @default.
• W2100422237 hasConceptScore W2100422237C2426938 @default.
• W2100422237 hasConceptScore W2100422237C2776012195 @default.
• W2100422237 hasConceptScore W2100422237C2776399701 @default.
• W2100422237 hasConceptScore W2100422237C2776439223 @default.
• W2100422237 hasConceptScore W2100422237C2778355172 @default.
• W2100422237 hasConceptScore W2100422237C2779489039 @default.
• W2100422237 hasConceptScore W2100422237C2779708577 @default.
• W2100422237 hasConceptScore W2100422237C2780805593 @default.
• W2100422237 hasConceptScore W2100422237C501593827 @default.
• W2100422237 hasConceptScore W2100422237C523546767 @default.
• W2100422237 hasConceptScore W2100422237C534529494 @default.
• W2100422237 hasConceptScore W2100422237C54355233 @default.
• W2100422237 hasConceptScore W2100422237C71924100 @default.
• W2100422237 hasConceptScore W2100422237C86803240 @default.
• W2100422237 hasConceptScore W2100422237C89423630 @default.
• W2100422237 hasConceptScore W2100422237C98274493 @default.
• W2100422237 hasIssue "sep23 3" @default.
• W2100422237 hasLocation W21004222371 @default.
• W2100422237 hasLocation W21004222372 @default.
• W2100422237 hasLocation W21004222373 @default.
• W2100422237 hasOpenAccess W2100422237 @default.

• next