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• W2100425308 abstract "Increased endothelin-1 (ET-1) disrupts angiogenesis in persistent pulmonary hypertension of the newborn (PPHN), but pathogenic mechanisms are unclear. Peroxisome proliferator activated receptor γ (PPARγ) is decreased in adult pulmonary hypertension, but whether ET-1-PPARγ interactions impair endothelial cell function and angiogenesis in PPHN remains unknown. We hypothesized that increased PPHN pulmonary artery endothelial cell (PAEC) ET-1 production decreases PPARγ signaling and impairs tube formation in vitro. Proximal PAECs were harvested from fetal sheep after partial ligation of the ductus arteriosus in utero (PPHN) and controls. PPARγ and phospho-PPARγ protein were compared between normal and PPHN PAECs ± ET-1 and bosentan (ET A /ET B receptor blocker). Tube formation was assessed in response to PPARγ agonists ± ET-1, N-nitro-l-arginine (LNA) (NOS inhibitor), and PPARγ siRNA. Endothelial NO synthase (eNOS), phospho-eNOS, and NO production were measured after exposure to PPARγ agonists and PPARγ siRNA. At baseline, PPHN PAECs demonstrate decreased tube formation and PPARγ protein expression and activity. PPARγ agonists restored PPHN tube formation to normal. ET-1 decreased normal and PPHN PAEC tube formation, which was rescued by PPARγ agonists. ET-1 decreased PPARγ protein and activity, which was prevented by bosentan. PPARγ agonists increased eNOS protein and activity and NO production in normal and PPHN PAECs. LNA inhibited the effect of PPARγ agonists on tube formation. PPARγ siRNA decreased eNOS protein and tube formation in normal PAECs. We conclude that ET-1 decreases PPARγ signaling and contributes to PAEC dysfunction and impaired angiogenesis in PPHN. We speculate that therapies aimed at decreasing ET-1 production will restore PPARγ signaling, preserve endothelial function, and improve angiogenesis in PPHN." @default.
• W2100425308 created "2016-06-24" @default.
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• W2100425308 date "2014-02-15" @default.
• W2100425308 modified "2023-09-24" @default.
• W2100425308 title "Endothelin-1 decreases endothelial PPARγ signaling and impairs angiogenesis after chronic intrauterine pulmonary hypertension" @default.
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• W2100425308 cites W1879669251 @default.
• W2100425308 cites W1964596560 @default.
• W2100425308 cites W1964653374 @default.
• W2100425308 cites W1978125779 @default.
• W2100425308 cites W1978343807 @default.
• W2100425308 cites W1982535038 @default.
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• W2100425308 cites W1989860776 @default.
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• W2100425308 doi "https://doi.org/10.1152/ajplung.00277.2013" @default.
• W2100425308 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3920227" @default.
• W2100425308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24337925" @default.
• W2100425308 hasPublicationYear "2014" @default.
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