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• W2100430134 abstract "Angiotensin II AT 2 receptors have been implicated to play a role in the regulation of renal/cardiovascular functions under pathological conditions. The present study is designed to investigate the function of the AT 2 receptors on renal sodium excretion and AT 2 receptor expression in the cortical membranes of streptozotocin (STZ)-induced diabetic rats. The STZ treatment led to a significant weight loss, hyperglycemia, and decrease in plasma insulin levels compared with control rats. STZ-induced diabetic rats had significantly elevated basal urine flow, urinary sodium excretion rate (U Na V), urinary fractional sodium excretion, and urinary cGMP compared with control rats. Infusion of PD-123319, an AT 2 receptor antagonist, caused a significant decrease in U Na V (μmol/min) in STZ-induced diabetic rats (1 ± 0.09 vs. 0.45 ± 0.1) but not in control rats (0.35 ± 0.05 vs. 0.4 ± 0.07). The decrease in U Na V was associated with a significant decrease in urinary cGMP levels (pmol/min) in STZ-induced diabetic rats (21 ± 2 vs. 10 ± 0.8) but not in control rats (11.75 ± 3 vs. 12.6 ± 2). The infusion of PD-123319 did not alter glomerular filtration rate (STZ: 0.3 ± 0.02 vs. 0.25 ± 0.03; control: 1.4 ± 0.05 vs. 1.5 ± 0.09 ml/min) or mean arterial pressure (STZ: 82 ± 3 vs. 79 ± 3.5; control: 90 ± 4 vs. 89 ± 4 mmHg), suggesting a tubular effect of the drug. Western blot analysis using an AT 2 receptor antibody revealed a significantly enhanced expression of the AT 2 receptor protein (∼45 kDa) in brush-border (∼50-fold) and basolateral membranes (∼80-fold) of STZ-induced diabetic compared with control rats. In conclusion, our data suggest that the tubular AT 2 receptors in diabetic rats are profoundly enhanced and possibly via a cGMP pathway promote sodium excretion in this model of diabetes." @default.
• W2100430134 created "2016-06-24" @default.
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• W2100430134 date "2006-02-01" @default.
• W2100430134 modified "2023-10-18" @default.
• W2100430134 title "Renal angiotensin II AT₂receptors promote natriuresis in streptozotocin-induced diabetic rats" @default.
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• W2100430134 doi "https://doi.org/10.1152/ajprenal.00092.2005" @default.
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