Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100438430> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2100438430 abstract "Interaction between long patch mismatch repair (MMR) and persistent DNA O6-methylguanine or 6-thioguanine (6-TG) is implicated in the cytotoxicity of methylating agents and 6-TG, respectively. Human cells with defective MMR tolerate DNA methylation damage and are cross-resistant to 6-TG. To determine whether MMR contributes to the lethal effects of persistent UV-induced DNA lesions, MMR deficiency was introduced into nucleotide excision repair (NER)-defective XP12RO cells. The doubly repair-defective cells, designated XP12ROB4, did not express detectable hMSH2 protein. They had the mutator phenotype, N-methyl-N-nitrosourea and 6-TG resistance typical of MMR-defective cells. Active MMR was not required for the cytotoxicity of UV light, and the hMSH2 defect did not detectably alter the survival of XP12ROB4. The level of spontaneous or UV-induced SCE was also similar in XP12RO and XP12ROB4, indicating that hMSH2 is not required for this recombination process. The combined deficiency in MMR and NER did not confer a significant degree of tolerance to ionizing radiation, and the survival of XP12RO and XP12ROB4 after gamma-radiation was similar. Although it recognizes and processes some persistent damaged or modified DNA base pairs, MMR is unlikely to serve as a general sensor of DNA damage." @default.
- W2100438430 created "2016-06-24" @default.
- W2100438430 creator A5022387331 @default.
- W2100438430 creator A5025181249 @default.
- W2100438430 creator A5035270156 @default.
- W2100438430 creator A5078200499 @default.
- W2100438430 date "1999-05-01" @default.
- W2100438430 modified "2023-10-14" @default.
- W2100438430 title "Combined mismatch and nucleotide excision repair defects in a human cell line: mismatch repair processes methylation but not UV- or ionizing radiation-induced DNA damage" @default.
- W2100438430 cites W1790962026 @default.
- W2100438430 cites W1963581476 @default.
- W2100438430 cites W1974292630 @default.
- W2100438430 cites W1976775167 @default.
- W2100438430 cites W1982640212 @default.
- W2100438430 cites W1986743116 @default.
- W2100438430 cites W1989052616 @default.
- W2100438430 cites W1990928895 @default.
- W2100438430 cites W1991064992 @default.
- W2100438430 cites W1992033907 @default.
- W2100438430 cites W2012732208 @default.
- W2100438430 cites W2013150677 @default.
- W2100438430 cites W2013590008 @default.
- W2100438430 cites W2014242714 @default.
- W2100438430 cites W2015532523 @default.
- W2100438430 cites W2030917339 @default.
- W2100438430 cites W2040512937 @default.
- W2100438430 cites W2041829432 @default.
- W2100438430 cites W2054046690 @default.
- W2100438430 cites W2068285061 @default.
- W2100438430 cites W2080028600 @default.
- W2100438430 cites W2080755801 @default.
- W2100438430 cites W2085315842 @default.
- W2100438430 cites W2086265877 @default.
- W2100438430 cites W2086395211 @default.
- W2100438430 cites W2094133050 @default.
- W2100438430 cites W2098489063 @default.
- W2100438430 cites W2115416778 @default.
- W2100438430 cites W2119882170 @default.
- W2100438430 cites W2141798197 @default.
- W2100438430 cites W2335531950 @default.
- W2100438430 doi "https://doi.org/10.1093/carcin/20.5.799" @default.
- W2100438430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10334196" @default.
- W2100438430 hasPublicationYear "1999" @default.
- W2100438430 type Work @default.
- W2100438430 sameAs 2100438430 @default.
- W2100438430 citedByCount "24" @default.
- W2100438430 countsByYear W21004384302013 @default.
- W2100438430 crossrefType "journal-article" @default.
- W2100438430 hasAuthorship W2100438430A5022387331 @default.
- W2100438430 hasAuthorship W2100438430A5025181249 @default.
- W2100438430 hasAuthorship W2100438430A5035270156 @default.
- W2100438430 hasAuthorship W2100438430A5078200499 @default.
- W2100438430 hasBestOaLocation W21004384301 @default.
- W2100438430 hasConcept C104317684 @default.
- W2100438430 hasConcept C104451858 @default.
- W2100438430 hasConcept C134935766 @default.
- W2100438430 hasConcept C143425029 @default.
- W2100438430 hasConcept C150194340 @default.
- W2100438430 hasConcept C153911025 @default.
- W2100438430 hasConcept C187206112 @default.
- W2100438430 hasConcept C190727270 @default.
- W2100438430 hasConcept C502942594 @default.
- W2100438430 hasConcept C54355233 @default.
- W2100438430 hasConcept C552990157 @default.
- W2100438430 hasConcept C60748783 @default.
- W2100438430 hasConcept C86803240 @default.
- W2100438430 hasConceptScore W2100438430C104317684 @default.
- W2100438430 hasConceptScore W2100438430C104451858 @default.
- W2100438430 hasConceptScore W2100438430C134935766 @default.
- W2100438430 hasConceptScore W2100438430C143425029 @default.
- W2100438430 hasConceptScore W2100438430C150194340 @default.
- W2100438430 hasConceptScore W2100438430C153911025 @default.
- W2100438430 hasConceptScore W2100438430C187206112 @default.
- W2100438430 hasConceptScore W2100438430C190727270 @default.
- W2100438430 hasConceptScore W2100438430C502942594 @default.
- W2100438430 hasConceptScore W2100438430C54355233 @default.
- W2100438430 hasConceptScore W2100438430C552990157 @default.
- W2100438430 hasConceptScore W2100438430C60748783 @default.
- W2100438430 hasConceptScore W2100438430C86803240 @default.
- W2100438430 hasLocation W21004384301 @default.
- W2100438430 hasLocation W21004384302 @default.
- W2100438430 hasOpenAccess W2100438430 @default.
- W2100438430 hasPrimaryLocation W21004384301 @default.
- W2100438430 hasRelatedWork W2030935068 @default.
- W2100438430 hasRelatedWork W2035967158 @default.
- W2100438430 hasRelatedWork W2037391945 @default.
- W2100438430 hasRelatedWork W2058461284 @default.
- W2100438430 hasRelatedWork W2347817641 @default.
- W2100438430 hasRelatedWork W2486637284 @default.
- W2100438430 hasRelatedWork W2580387602 @default.
- W2100438430 hasRelatedWork W2605752534 @default.
- W2100438430 hasRelatedWork W3082794616 @default.
- W2100438430 hasRelatedWork W4225393415 @default.
- W2100438430 isParatext "false" @default.
- W2100438430 isRetracted "false" @default.
- W2100438430 magId "2100438430" @default.
- W2100438430 workType "article" @default.