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- W2100442068 abstract "While considerable effort has focused on developing positron emission tomography β-amyloid imaging radiotracers for the early diagnosis of Alzheimer's disease, no radiotracer is available for the non-invasive quantification of tau. In this study, we detail the characterization of 18F-THK523 as a novel tau imaging radiotracer. In vitro binding studies demonstrated that 18F-THK523 binds with higher affinity to a greater number of binding sites on recombinant tau (K18Δ280K) compared with β-amyloid1–42 fibrils. Autoradiographic and histofluorescence analysis of human hippocampal serial sections with Alzheimer's disease exhibited positive THK523 binding that co-localized with immunoreactive tau pathology, but failed to highlight β-amyloid plaques. Micro-positron emission tomography analysis demonstrated significantly higher retention of 18F-THK523 (48%; P < 0.007) in tau transgenic mice brains compared with their wild-type littermates or APP/PS1 mice. The preclinical examination of THK523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo, indicating that 18F-THK523 fulfils ligand criteria for human imaging trials." @default.
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- W2100442068 date "2011-03-24" @default.
- W2100442068 modified "2023-10-17" @default.
- W2100442068 title "18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease" @default.
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- W2100442068 doi "https://doi.org/10.1093/brain/awr038" @default.
- W2100442068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21436112" @default.
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