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• W2100448463 abstract "The double postnatal stress model (brief maternal separation plus sham injection daily applied from birth to weaning) induces metabolic alterations similar to type 2 diabetes in young-adult male mice. We verify whether 1) the stress also induces brain metabolic–functional alterations connected to diabetes and 2) different alterations are modulated selectively by two stress-damaged endogenous systems (opioid- and/or ACTH–corticosteroid-linked). Here, diabetes-like metabolic plus neurophysiologic–neurometabolic parameters are studied in adult mice following postnatal stress and drug treatment. Surprisingly, together with ‘classic’ diabetes-like alterations, the stress model induces in young-adult mice significantly enhanced brain neurometabolic–neurophysiologic performances, consisting of decreased latency to flash-visual evoked potentials (−∼8%); increased level (+∼40%) and reduced latency (−∼30%) of NAD(P)H autofluorescence postsynaptic signals following electric stimuli; enhanced passive avoidance learning (+∼135% latency); and enhanced brain-derived neurotrophic factor level (+∼70%). Postnatal treatment with the opioid receptor antagonist naloxone prevents some alterations, moreover the treatment with antisense (AS; AS vs proopiomelanocortin mRNA) draws all parameters to control levels, thus showing that some alterations are bound to endogenous opioid-system hyper-functioning, while others depend on ACTH–corticosterone system hyper-functioning. Our stress model induces diabetes-like metabolic alterations coupled to enhanced brain neurometabolic–neurophysiologic performances. Taken all together, these findings are compatible with an ‘enduring acute-stress’ reaction, which puts mice in favorable survival situations vs controls. However, prolonged hormonal–metabolic imbalances are expected to also produce diabetes-like complications at later ages in stressed mice." @default.
• W2100448463 created "2016-06-24" @default.
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• W2100448463 date "2012-10-08" @default.
• W2100448463 modified "2023-09-25" @default.
• W2100448463 title "Enhanced brain performance in mice following postnatal stress" @default.
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• W2100448463 doi "https://doi.org/10.1530/joe-12-0369" @default.
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