Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100463887> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2100463887 abstract "Parathyroid hormone (PTH)-stimulated production of cAMP by intact human osteoblast-like SaOS-2 cells is diminished by pretreatment with 17 beta-estradiol (E2). The goal of the present study was to determine whether E2, affected adenylyl cyclase activity in cell membranes. Cells were deprived of steroid hormones for 24 h and then incubated with E2 (1 nM) or vehicle for 12 h. Cell membranes were prepared and incubated with [alpha-32P]-ATP in the absence or presence of agonist, and the amount of [32P]-cAMP produced was measured to quantify adenylyl cyclase activity. There was less cAMP produced by membranes from E2-treated cells in response to PTH, GTP gamma S, forskolin, and Mn2+. E2 had no effect on the amounts of Gs or Gi. We propose that pretreatment of SaOS-2 cells with E2 reduced membrane cyclase activity, at least in part, by actions on the PTH-sensitive adenylyl cyclase and/or the G protein-adenylyl cyclase complex." @default.
- W2100463887 created "2016-06-24" @default.
- W2100463887 creator A5028563496 @default.
- W2100463887 creator A5073132850 @default.
- W2100463887 date "1996-08-01" @default.
- W2100463887 modified "2023-10-16" @default.
- W2100463887 title "Pretreatment with 17β-Estradiol Attenuates Basal- and PTH-Stimulated Membrane Adenylyl Cyclase Activity in Human Osteoblast-like SAOS-2 Cells" @default.
- W2100463887 doi "https://doi.org/10.1006/bbrc.1996.1173" @default.
- W2100463887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8769137" @default.
- W2100463887 hasPublicationYear "1996" @default.
- W2100463887 type Work @default.
- W2100463887 sameAs 2100463887 @default.
- W2100463887 citedByCount "5" @default.
- W2100463887 crossrefType "journal-article" @default.
- W2100463887 hasAuthorship W2100463887A5028563496 @default.
- W2100463887 hasAuthorship W2100463887A5073132850 @default.
- W2100463887 hasConcept C115466790 @default.
- W2100463887 hasConcept C118716 @default.
- W2100463887 hasConcept C126322002 @default.
- W2100463887 hasConcept C134018914 @default.
- W2100463887 hasConcept C176303035 @default.
- W2100463887 hasConcept C181199279 @default.
- W2100463887 hasConcept C185592680 @default.
- W2100463887 hasConcept C202751555 @default.
- W2100463887 hasConcept C24998067 @default.
- W2100463887 hasConcept C2751546 @default.
- W2100463887 hasConcept C2778260815 @default.
- W2100463887 hasConcept C2779178603 @default.
- W2100463887 hasConcept C2779276759 @default.
- W2100463887 hasConcept C2780069284 @default.
- W2100463887 hasConcept C2781208988 @default.
- W2100463887 hasConcept C519063684 @default.
- W2100463887 hasConcept C55493867 @default.
- W2100463887 hasConcept C69101867 @default.
- W2100463887 hasConcept C71924100 @default.
- W2100463887 hasConcept C86803240 @default.
- W2100463887 hasConceptScore W2100463887C115466790 @default.
- W2100463887 hasConceptScore W2100463887C118716 @default.
- W2100463887 hasConceptScore W2100463887C126322002 @default.
- W2100463887 hasConceptScore W2100463887C134018914 @default.
- W2100463887 hasConceptScore W2100463887C176303035 @default.
- W2100463887 hasConceptScore W2100463887C181199279 @default.
- W2100463887 hasConceptScore W2100463887C185592680 @default.
- W2100463887 hasConceptScore W2100463887C202751555 @default.
- W2100463887 hasConceptScore W2100463887C24998067 @default.
- W2100463887 hasConceptScore W2100463887C2751546 @default.
- W2100463887 hasConceptScore W2100463887C2778260815 @default.
- W2100463887 hasConceptScore W2100463887C2779178603 @default.
- W2100463887 hasConceptScore W2100463887C2779276759 @default.
- W2100463887 hasConceptScore W2100463887C2780069284 @default.
- W2100463887 hasConceptScore W2100463887C2781208988 @default.
- W2100463887 hasConceptScore W2100463887C519063684 @default.
- W2100463887 hasConceptScore W2100463887C55493867 @default.
- W2100463887 hasConceptScore W2100463887C69101867 @default.
- W2100463887 hasConceptScore W2100463887C71924100 @default.
- W2100463887 hasConceptScore W2100463887C86803240 @default.
- W2100463887 hasLocation W21004638871 @default.
- W2100463887 hasLocation W21004638872 @default.
- W2100463887 hasOpenAccess W2100463887 @default.
- W2100463887 hasPrimaryLocation W21004638871 @default.
- W2100463887 hasRelatedWork W1498678677 @default.
- W2100463887 hasRelatedWork W1539631646 @default.
- W2100463887 hasRelatedWork W1972038609 @default.
- W2100463887 hasRelatedWork W2015286298 @default.
- W2100463887 hasRelatedWork W2036154804 @default.
- W2100463887 hasRelatedWork W2037022019 @default.
- W2100463887 hasRelatedWork W2085480224 @default.
- W2100463887 hasRelatedWork W2086842408 @default.
- W2100463887 hasRelatedWork W2100463887 @default.
- W2100463887 hasRelatedWork W2150623384 @default.
- W2100463887 isParatext "false" @default.
- W2100463887 isRetracted "false" @default.
- W2100463887 magId "2100463887" @default.
- W2100463887 workType "article" @default.