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- W2100477029 abstract "Summary: Maintenance of the peripheral T‐cell pool throughout the life requires uninterrupted generation of T cells. The majority of peripheral T cells are generated in the thymus. However, the thymus does not contain hematopoietic progenitors with unlimited self‐renewing potential, and continuous production of T cells requires importation of such progenitors from the bone marrow into the thymus. Thymus‐homing progenitors enter the thymus and subsequently migrate throughout distinct intrathymic microenvironments while differentiating into mature T cells. At each step of this scheduled journey, developing thymocytes interact intimately with the local stroma, which allow them to proceed to the next stage of their differentiation and maturation program. Undoubtedly, thymocyte/stroma interactions are instrumental for both thymocytes and stroma, because only their ongoing interplay generates and maintains a fully operational thymus, able to guarantee unimpaired T‐cell supply. Therefore, proper T‐cell generation intrinsically involves polarized cell migration during both adult life and embryogenesis when the thymus primordium develops into a functional thymus. The molecular mechanisms controlling cell migration during thymus development and postnatal T‐cell differentiation are beginning to be defined. This review focuses on recent data regarding the role of cell migration in both colonization of the fetal thymus and T‐cell development during postnatal life in mice." @default.
- W2100477029 created "2016-06-24" @default.
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- W2100477029 creator A5049442876 @default.
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- W2100477029 date "2006-01-31" @default.
- W2100477029 modified "2023-10-16" @default.
- W2100477029 title "Trafficking on serpentines: molecular insight on how maturating T cells find their winding paths in the thymus" @default.
- W2100477029 cites W1496114012 @default.
- W2100477029 cites W1496442189 @default.
- W2100477029 cites W1566252891 @default.
- W2100477029 cites W1596311805 @default.
- W2100477029 cites W1609653960 @default.
- W2100477029 cites W1659851300 @default.
- W2100477029 cites W1807544031 @default.
- W2100477029 cites W1853386900 @default.
- W2100477029 cites W1885758189 @default.
- W2100477029 cites W1936405794 @default.
- W2100477029 cites W1963495112 @default.
- W2100477029 cites W1963809310 @default.
- W2100477029 cites W1973473592 @default.
- W2100477029 cites W197701292 @default.
- W2100477029 cites W1992859876 @default.
- W2100477029 cites W2000054809 @default.
- W2100477029 cites W2003756149 @default.
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- W2100477029 cites W2008582777 @default.
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- W2100477029 cites W2026129212 @default.
- W2100477029 cites W2027459391 @default.
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- W2100477029 doi "https://doi.org/10.1111/j.0105-2896.2006.00351.x" @default.
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