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- W2100488616 abstract "The development of anticonvulsant tolerance with RO 16-6028, a benzodiazepine receptor partial agonist, was assessed in mice using an i.v. infusion of pentylenetetrazol as the convulsive stimulus. In contrast to other benzodiazepines tested previously in this seizure model the anticonvulsant protection afforded by RO 16-6028 did not change significantly during 10 days treatment (2 mg/kg b.i.d.). This result supports the hypothesis that partial agonists at the benzodiazepine receptor may induce less tolerance and/or dependence than full agonists." @default.
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- W2100488616 date "1988-03-01" @default.
- W2100488616 modified "2023-10-13" @default.
- W2100488616 title "RO 16-6028,a benzodiazepine receptor partial agonist, does not exhibit anticonvulasant tolerance in mice" @default.
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- W2100488616 doi "https://doi.org/10.1016/0014-2999(88)90788-1" @default.
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