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• W2100508051 abstract "Microbial transformation of imbricatolic acid (1) by Aspergillus niger afforded 1alpha-hydroxyimbricatolic acid (2), while transformation with Rhizopus nigricans yielded 15-hydroxy-8,17-epoxylabdan-19-oic acid (3). When the diterpene 1 was added to a Cunninghamella echinulata culture, the main products were the microbial metabolites mycophenolic acid (4) and its 3-hydroxy derivative 5. All the structures were elucidated by spectroscopic methods. The cytotoxicity of these compounds towards human lung fibroblasts and AGS cells was assessed. While 4 and 5 showed low cytotoxicity, with IC50 values > 1000 microM against AGS cells and fibroblasts, 1alpha-hydroxyimbricatolic acid (2) presented moderate toxicity towards these targets, with IC50 values of 307 and 631 microM, respectively. The structure of 2 is presented for the first time." @default.
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• W2100508051 date "2007-05-21" @default.
• W2100508051 modified "2023-10-05" @default.
• W2100508051 title "Biotransformations of Imbricatolic Acid by Aspergillus niger and Rhizopus nigricans Cultures" @default.
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• W2100508051 doi "https://doi.org/10.3390/12051092" @default.
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