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- W2100516030 endingPage "859" @default.
- W2100516030 startingPage "847" @default.
- W2100516030 abstract "Mast cells are of hematopoietic origin but typically complete their maturation in peripheral connective tissues, especially those near epithelial surfaces. Mast cells express receptors that bind IgE antibodies with high affinity (FcepsilonRI), and aggregation of these FcepsilonRI by the reaction of cell-bound IgE with specific antigens induces mast cells to secrete a broad spectrum of biologically active preformed or lipid mediators, as well as many cytokines. Mast cells are widely thought to be essential for the expression of acute allergic reactions, but the importance of mast cells in late-phase reactions and chronic allergic inflammation has remained controversial. Although it is clear that many cell types may be involved in the expression of late-phase reactions and chronic allergic inflammation, studies in genetically mast cell-deficient and congenic normal mice indicate that mast cells may be critical for the full expression of certain features of late-phase reactions and may also contribute importantly to clinically relevant aspects of chronic allergic inflammation. Moreover, the pattern of cytokines that can be produced by mast cell populations, and the enhancement of such cytokine production in mast cells that have undergone IgE-dependent up-regulation of their surface expression of FcepsilonRI, suggests that mast cells may contribute to allergic diseases (and host defense) by acting as immunoregulatory cells, as well as by providing effector cell function." @default.
- W2100516030 created "2016-06-24" @default.
- W2100516030 creator A5004151297 @default.
- W2100516030 creator A5013602118 @default.
- W2100516030 date "2000-05-01" @default.
- W2100516030 modified "2023-10-18" @default.
- W2100516030 title "The diverse potential effector and immunoregulatory roles of mast cells in allergic disease" @default.
- W2100516030 cites W1508629699 @default.
- W2100516030 cites W1514376893 @default.
- W2100516030 cites W1519269060 @default.
- W2100516030 cites W1552274890 @default.
- W2100516030 cites W1560052830 @default.
- W2100516030 cites W1562941697 @default.
- W2100516030 cites W1574785846 @default.
- W2100516030 cites W1578107688 @default.
- W2100516030 cites W1580222016 @default.
- W2100516030 cites W1599496006 @default.
- W2100516030 cites W1601094160 @default.
- W2100516030 cites W1655614253 @default.
- W2100516030 cites W1676650238 @default.
- W2100516030 cites W1683039388 @default.
- W2100516030 cites W1795089629 @default.
- W2100516030 cites W1838555675 @default.
- W2100516030 cites W1890629173 @default.
- W2100516030 cites W1900773160 @default.
- W2100516030 cites W1910182345 @default.
- W2100516030 cites W1955752095 @default.
- W2100516030 cites W1963992704 @default.
- W2100516030 cites W1964094256 @default.
- W2100516030 cites W1964806452 @default.
- W2100516030 cites W1968335934 @default.
- W2100516030 cites W1968773217 @default.
- W2100516030 cites W1972304758 @default.
- W2100516030 cites W1973282117 @default.
- W2100516030 cites W1975430600 @default.
- W2100516030 cites W1976755134 @default.
- W2100516030 cites W1981906652 @default.
- W2100516030 cites W1982256713 @default.
- W2100516030 cites W1984554268 @default.
- W2100516030 cites W1986554240 @default.
- W2100516030 cites W1986875719 @default.
- W2100516030 cites W1987919154 @default.
- W2100516030 cites W1992763270 @default.
- W2100516030 cites W1994586690 @default.
- W2100516030 cites W1995790272 @default.
- W2100516030 cites W1997034316 @default.
- W2100516030 cites W1998539607 @default.
- W2100516030 cites W1998783767 @default.
- W2100516030 cites W2001687270 @default.
- W2100516030 cites W2005549930 @default.
- W2100516030 cites W2007990557 @default.
- W2100516030 cites W2013394968 @default.
- W2100516030 cites W2017014849 @default.
- W2100516030 cites W2020666279 @default.
- W2100516030 cites W2021475285 @default.
- W2100516030 cites W2022277127 @default.
- W2100516030 cites W2024158949 @default.
- W2100516030 cites W2026537967 @default.
- W2100516030 cites W2028396701 @default.
- W2100516030 cites W2029708509 @default.
- W2100516030 cites W2030554487 @default.
- W2100516030 cites W2032327624 @default.
- W2100516030 cites W2032887423 @default.
- W2100516030 cites W2033330205 @default.
- W2100516030 cites W2037899271 @default.
- W2100516030 cites W2038273933 @default.
- W2100516030 cites W2044309378 @default.
- W2100516030 cites W2046151476 @default.
- W2100516030 cites W2047328650 @default.
- W2100516030 cites W2047480131 @default.
- W2100516030 cites W2048761922 @default.
- W2100516030 cites W2049371451 @default.
- W2100516030 cites W2051711743 @default.
- W2100516030 cites W2055203083 @default.
- W2100516030 cites W2055739155 @default.
- W2100516030 cites W2056624083 @default.
- W2100516030 cites W2056734272 @default.
- W2100516030 cites W2057345517 @default.
- W2100516030 cites W2058464353 @default.
- W2100516030 cites W2059534402 @default.
- W2100516030 cites W2060678151 @default.
- W2100516030 cites W2061092989 @default.
- W2100516030 cites W2061193280 @default.
- W2100516030 cites W2063203571 @default.
- W2100516030 cites W2065149104 @default.
- W2100516030 cites W2065596872 @default.
- W2100516030 cites W2066188364 @default.
- W2100516030 cites W2067523166 @default.
- W2100516030 cites W2067627877 @default.
- W2100516030 cites W2069808501 @default.
- W2100516030 cites W2072163134 @default.
- W2100516030 cites W2073955822 @default.
- W2100516030 cites W2076762630 @default.
- W2100516030 cites W2080884443 @default.
- W2100516030 cites W2088771184 @default.
- W2100516030 cites W2088958570 @default.
- W2100516030 cites W2093582457 @default.
- W2100516030 cites W2097702927 @default.