FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100520341> ?p ?o ?g. }

• W2100520341 endingPage "327" @default.
• W2100520341 startingPage "317" @default.
• W2100520341 abstract "In the present study, we show that a combination of sulindac and arsenic trioxide (ATO) induces more extensive apoptosis than either drug alone in H1299 human non-small cell lung carcinoma (NSCLC) cells. Treatment with sulindac/ATO triggered three major apoptotic signaling events, namely, collapse of the mitochondrial membrane potential, release of cytochrome c, and activation of caspases. Furthermore, the sulindac/ATO combination induced reactive oxygen species (ROS) generation, and the antioxidant, N-acetyl-l-cysteine, blocked this apoptotic signaling. The c-Jun NH2-terminal kinase (JNK) was activated downstream of ROS production in H1299 cells. Blockage of JNK by pretreatment with SP600125, a pharmacological inhibitor, or transfection with dominant-negative (DN) JNK1 vectors abrogated sulindac/ATO-induced apoptosis, as evident from the disruption of caspase activation. Interestingly, a slower migrating Bcl-xL band was observed on immunoblots after treatment of cells with sulindac/ATO. The band was absent upon the treatment of cell lysates with λ protein phosphatase. Moreover, confocal microscopy findings disclose that active JNK translocates to mitochondria. Treatment with SP600125 and transfection with DN-JNK blocked Bcl-xL phosphorylation, suggesting that JNK plays an important role in sulindac/ATO-induced Bcl-xL phosphorylation. In conclusion, in H1299 human NSCLC cells, sulindac and ATO synergistically induce a high degree of apoptosis, which is mediated by the ROS-dependent JNK activation pathway via Bcl-xL phosphorylation." @default.
• W2100520341 created "2016-06-24" @default.
• W2100520341 creator A5006019721 @default.
• W2100520341 creator A5022219891 @default.
• W2100520341 creator A5035568162 @default.
• W2100520341 creator A5036301239 @default.
• W2100520341 creator A5038978525 @default.
• W2100520341 creator A5040492383 @default.
• W2100520341 creator A5044918477 @default.
• W2100520341 creator A5051867302 @default.
• W2100520341 creator A5065785561 @default.
• W2100520341 creator A5068520126 @default.
• W2100520341 creator A5082018557 @default.
• W2100520341 creator A5085690999 @default.
• W2100520341 creator A5091068973 @default.
• W2100520341 date "2008-09-01" @default.
• W2100520341 modified "2023-10-13" @default.
• W2100520341 title "A combination of sulindac and arsenic trioxide synergistically induces apoptosis in human lung cancer H1299 cells via c-Jun NH2-terminal kinase-dependent Bcl-xL phosphorylation" @default.
• W2100520341 cites W1510592624 @default.
• W2100520341 cites W1571529930 @default.
• W2100520341 cites W1598719623 @default.
• W2100520341 cites W1599940872 @default.
• W2100520341 cites W1968835387 @default.
• W2100520341 cites W1972025137 @default.
• W2100520341 cites W1982393289 @default.
• W2100520341 cites W1984015618 @default.
• W2100520341 cites W1984665850 @default.
• W2100520341 cites W1991865867 @default.
• W2100520341 cites W1992361007 @default.
• W2100520341 cites W1999605572 @default.
• W2100520341 cites W2008046168 @default.
• W2100520341 cites W2022273982 @default.
• W2100520341 cites W2025850775 @default.
• W2100520341 cites W2030015711 @default.
• W2100520341 cites W2031744617 @default.
• W2100520341 cites W2040353449 @default.
• W2100520341 cites W2055884802 @default.
• W2100520341 cites W2056324134 @default.
• W2100520341 cites W2056543772 @default.
• W2100520341 cites W2058591356 @default.
• W2100520341 cites W2067202868 @default.
• W2100520341 cites W2073235168 @default.
• W2100520341 cites W2084533871 @default.
• W2100520341 cites W2094331623 @default.
• W2100520341 cites W2098712005 @default.
• W2100520341 cites W2101625677 @default.
• W2100520341 cites W2106410559 @default.
• W2100520341 cites W2128432102 @default.
• W2100520341 cites W2137912423 @default.
• W2100520341 cites W2139184637 @default.
• W2100520341 cites W2144011146 @default.
• W2100520341 cites W2148061274 @default.
• W2100520341 cites W2150048195 @default.
• W2100520341 cites W2158380484 @default.
• W2100520341 cites W2158951763 @default.
• W2100520341 cites W2188651990 @default.
• W2100520341 doi "https://doi.org/10.1016/j.lungcan.2008.01.002" @default.
• W2100520341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18281123" @default.
• W2100520341 hasPublicationYear "2008" @default.
• W2100520341 type Work @default.
• W2100520341 sameAs 2100520341 @default.
• W2100520341 citedByCount "31" @default.
• W2100520341 countsByYear W21005203412012 @default.
• W2100520341 countsByYear W21005203412013 @default.
• W2100520341 countsByYear W21005203412014 @default.
• W2100520341 countsByYear W21005203412015 @default.
• W2100520341 countsByYear W21005203412016 @default.
• W2100520341 countsByYear W21005203412018 @default.
• W2100520341 countsByYear W21005203412019 @default.
• W2100520341 countsByYear W21005203412020 @default.
• W2100520341 countsByYear W21005203412021 @default.
• W2100520341 crossrefType "journal-article" @default.
• W2100520341 hasAuthorship W2100520341A5006019721 @default.
• W2100520341 hasAuthorship W2100520341A5022219891 @default.
• W2100520341 hasAuthorship W2100520341A5035568162 @default.
• W2100520341 hasAuthorship W2100520341A5036301239 @default.
• W2100520341 hasAuthorship W2100520341A5038978525 @default.
• W2100520341 hasAuthorship W2100520341A5040492383 @default.
• W2100520341 hasAuthorship W2100520341A5044918477 @default.
• W2100520341 hasAuthorship W2100520341A5051867302 @default.
• W2100520341 hasAuthorship W2100520341A5065785561 @default.
• W2100520341 hasAuthorship W2100520341A5068520126 @default.
• W2100520341 hasAuthorship W2100520341A5082018557 @default.
• W2100520341 hasAuthorship W2100520341A5085690999 @default.
• W2100520341 hasAuthorship W2100520341A5091068973 @default.
• W2100520341 hasConcept C11960822 @default.
• W2100520341 hasConcept C178666793 @default.
• W2100520341 hasConcept C181912034 @default.
• W2100520341 hasConcept C184235292 @default.
• W2100520341 hasConcept C185592680 @default.
• W2100520341 hasConcept C190283241 @default.
• W2100520341 hasConcept C2776241388 @default.
• W2100520341 hasConcept C2778484676 @default.
• W2100520341 hasConcept C2780386689 @default.
• W2100520341 hasConcept C29311851 @default.
• W2100520341 hasConcept C48349386 @default.
• W2100520341 hasConcept C502942594 @default.
• W2100520341 hasConcept C54009773 @default.

• next