FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100528030> ?p ?o ?g. }

• W2100528030 abstract "Cranial visceral afferents contained within the solitary tract (ST) contact second-order neurons in the nucleus of the solitary tract (NTS) and release the excitatory amino acid glutamate via three distinct exocytosis pathways; synchronous, asynchronous, and spontaneous release. The presence of TRPV1 in the central terminals of a majority of ST afferents conveys activity-dependent asynchronous glutamate release and provides a temperature sensitive calcium conductance which largely determines the rate of spontaneous vesicle fusion. TRPV1 is present in unmyelinated C-fiber afferents and these facilitated forms of glutamate release may underlie the relative strength of C-fibers in activating autonomic reflex pathways. However, pharmacological blockade of TRPV1 signaling eliminates only ~50% of the asynchronous profile and attenuates the temperature sensitivity of spontaneous release indicating additional thermosensitive calcium influx pathways may exist which mediate these forms of vesicle release. In the present study we isolate the contribution of TRPV1 independent forms of glutamate release at ST-NTS synapses. We found ST afferent innervation at NTS neurons and synchronous vesicle release from TRPV1 KO mice was not different to control animals; however, only half of TRPV1 KO ST afferents completely lacked asynchronous glutamate release. Further, temperature driven spontaneous rates of vesicle release were not different from 33˚ - 37˚C between control and TRPV1 KO afferents. These findings suggest additional temperature dependent mechanisms controlling asynchronous and thermosensitive spontaneous release at physiological temperatures, possibly mediated by additional thermosensitive TRP channels in primary afferent terminals." @default.
• W2100528030 created "2016-06-24" @default.
• W2100528030 creator A5013204044 @default.
• W2100528030 creator A5035270837 @default.
• W2100528030 creator A5068156554 @default.
• W2100528030 date "2014-01-01" @default.
• W2100528030 modified "2023-09-25" @default.
• W2100528030 title "Isolation of TRPV1 independent mechanisms of spontaneous and asynchronous glutamate release at primary afferent to NTS synapses" @default.
• W2100528030 cites W1492591187 @default.
• W2100528030 cites W1591755406 @default.
• W2100528030 cites W1964779574 @default.
• W2100528030 cites W1969127339 @default.
• W2100528030 cites W1980010331 @default.
• W2100528030 cites W1984912966 @default.
• W2100528030 cites W2008048120 @default.
• W2100528030 cites W2016048441 @default.
• W2100528030 cites W2028281748 @default.
• W2100528030 cites W2041165725 @default.
• W2100528030 cites W2041971204 @default.
• W2100528030 cites W2058808922 @default.
• W2100528030 cites W2061040353 @default.
• W2100528030 cites W2062752956 @default.
• W2100528030 cites W2083155364 @default.
• W2100528030 cites W2102364237 @default.
• W2100528030 cites W2111467441 @default.
• W2100528030 cites W2119084915 @default.
• W2100528030 cites W2124418433 @default.
• W2100528030 cites W2126551962 @default.
• W2100528030 cites W2127012396 @default.
• W2100528030 cites W2132634436 @default.
• W2100528030 cites W2133669849 @default.
• W2100528030 cites W2142790764 @default.
• W2100528030 cites W2145617354 @default.
• W2100528030 cites W2293003331 @default.
• W2100528030 cites W2410841626 @default.
• W2100528030 cites W2413462895 @default.
• W2100528030 cites W2490224235 @default.
• W2100528030 doi "https://doi.org/10.3389/fnins.2014.00006" @default.
• W2100528030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3907708" @default.
• W2100528030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24550768" @default.
• W2100528030 hasPublicationYear "2014" @default.
• W2100528030 type Work @default.
• W2100528030 sameAs 2100528030 @default.
• W2100528030 citedByCount "14" @default.
• W2100528030 countsByYear W21005280302015 @default.
• W2100528030 countsByYear W21005280302016 @default.
• W2100528030 countsByYear W21005280302018 @default.
• W2100528030 countsByYear W21005280302019 @default.
• W2100528030 countsByYear W21005280302020 @default.
• W2100528030 countsByYear W21005280302021 @default.
• W2100528030 countsByYear W21005280302022 @default.
• W2100528030 countsByYear W21005280302023 @default.
• W2100528030 crossrefType "journal-article" @default.
• W2100528030 hasAuthorship W2100528030A5013204044 @default.
• W2100528030 hasAuthorship W2100528030A5035270837 @default.
• W2100528030 hasAuthorship W2100528030A5068156554 @default.
• W2100528030 hasBestOaLocation W21005280301 @default.
• W2100528030 hasConcept C112592302 @default.
• W2100528030 hasConcept C12554922 @default.
• W2100528030 hasConcept C130316041 @default.
• W2100528030 hasConcept C148785051 @default.
• W2100528030 hasConcept C155164980 @default.
• W2100528030 hasConcept C160145004 @default.
• W2100528030 hasConcept C169760540 @default.
• W2100528030 hasConcept C170493617 @default.
• W2100528030 hasConcept C17077164 @default.
• W2100528030 hasConcept C175969161 @default.
• W2100528030 hasConcept C185592680 @default.
• W2100528030 hasConcept C2780838160 @default.
• W2100528030 hasConcept C41625074 @default.
• W2100528030 hasConcept C49039625 @default.
• W2100528030 hasConcept C529278444 @default.
• W2100528030 hasConcept C55493867 @default.
• W2100528030 hasConcept C61174792 @default.
• W2100528030 hasConcept C86803240 @default.
• W2100528030 hasConcept C95444343 @default.
• W2100528030 hasConceptScore W2100528030C112592302 @default.
• W2100528030 hasConceptScore W2100528030C12554922 @default.
• W2100528030 hasConceptScore W2100528030C130316041 @default.
• W2100528030 hasConceptScore W2100528030C148785051 @default.
• W2100528030 hasConceptScore W2100528030C155164980 @default.
• W2100528030 hasConceptScore W2100528030C160145004 @default.
• W2100528030 hasConceptScore W2100528030C169760540 @default.
• W2100528030 hasConceptScore W2100528030C170493617 @default.
• W2100528030 hasConceptScore W2100528030C17077164 @default.
• W2100528030 hasConceptScore W2100528030C175969161 @default.
• W2100528030 hasConceptScore W2100528030C185592680 @default.
• W2100528030 hasConceptScore W2100528030C2780838160 @default.
• W2100528030 hasConceptScore W2100528030C41625074 @default.
• W2100528030 hasConceptScore W2100528030C49039625 @default.
• W2100528030 hasConceptScore W2100528030C529278444 @default.
• W2100528030 hasConceptScore W2100528030C55493867 @default.
• W2100528030 hasConceptScore W2100528030C61174792 @default.
• W2100528030 hasConceptScore W2100528030C86803240 @default.
• W2100528030 hasConceptScore W2100528030C95444343 @default.
• W2100528030 hasLocation W21005280301 @default.
• W2100528030 hasLocation W21005280302 @default.
• W2100528030 hasLocation W21005280303 @default.
• W2100528030 hasLocation W21005280304 @default.
• W2100528030 hasOpenAccess W2100528030 @default.

• next