FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100532943> ?p ?o ?g. }

• W2100532943 endingPage "179" @default.
• W2100532943 startingPage "167" @default.
• W2100532943 abstract "The high degree of bone marrow cell (BMC) plasticity has prompted us to test its restoration possibility in inner ear repair. Our aim was to determine the potential of these cells to transdifferentiate into specialized cochlea cell types after acoustic injury and BMC mobilization. Lethally irradiated mice were transplanted with BMCs from green fluorescent protein (GFP) transgenic mice and subjected to acoustic deafening 3 months later. In a separate experiment, stem cell factor and granulocyte colony-stimulating factor were administered to test the effect of BMC mobilization on bone marrow-derived cell (BMDC) transdifferentiation. All mice showed almost complete chimerism 3 months after bone marrow transplantation. Upon acoustic trauma, robust BMDC migration was observed in the deafened cochlea. GFP+ cell migration was most prominent during the first week after acoustic deafening, and these cells accumulated significantly at the spiral ligament, perilymphatic compartment walls, and limbus regions. Most of the BMDCs expressed CD45 and CD68 and were identified as macrophages. Upregulation of stromal-derived factor 1 (SDF-1) was also observed in the spiral ligament during the first week after acoustic deafening. Cytokine treatment resulted in increased BMC mobilization in the systemic circulation. However, the presence of any stem cell progenitors or the differentiation of BMDCs into any cell types expressing cochlea sensory, supporting, fibrocytic, or neuronal markers were not detected in the deafened cochlea. In conclusion, we have demonstrated the homing capability of BMDCs to the deafened cochlea, and these cells displayed mature hematopoietic properties without spontaneous transdifferentiation to any cochlea cell types after acoustic trauma or bone marrow mobilization. J. Comp. Neurol. 509:167–179, 2008. © 2008 Wiley-Liss, Inc." @default.
• W2100532943 created "2016-06-24" @default.
• W2100532943 creator A5029923108 @default.
• W2100532943 creator A5067791416 @default.
• W2100532943 creator A5068324570 @default.
• W2100532943 date "2008-07-10" @default.
• W2100532943 modified "2023-09-25" @default.
• W2100532943 title "Bone marrow-derived cells that home to acoustic deafened cochlea preserved their hematopoietic identity" @default.
• W2100532943 cites W109974507 @default.
• W2100532943 cites W1482140147 @default.
• W2100532943 cites W1506224280 @default.
• W2100532943 cites W1514371770 @default.
• W2100532943 cites W1621991227 @default.
• W2100532943 cites W1631250427 @default.
• W2100532943 cites W1894599871 @default.
• W2100532943 cites W1938170556 @default.
• W2100532943 cites W1963528303 @default.
• W2100532943 cites W1966989826 @default.
• W2100532943 cites W1967075924 @default.
• W2100532943 cites W1970895440 @default.
• W2100532943 cites W1972736348 @default.
• W2100532943 cites W1974631564 @default.
• W2100532943 cites W1975277850 @default.
• W2100532943 cites W1977437881 @default.
• W2100532943 cites W1980817996 @default.
• W2100532943 cites W1982022033 @default.
• W2100532943 cites W1983851734 @default.
• W2100532943 cites W1984425391 @default.
• W2100532943 cites W1986826310 @default.
• W2100532943 cites W1988868629 @default.
• W2100532943 cites W1989737822 @default.
• W2100532943 cites W1991248271 @default.
• W2100532943 cites W1999481607 @default.
• W2100532943 cites W2001675896 @default.
• W2100532943 cites W2004050413 @default.
• W2100532943 cites W2005154068 @default.
• W2100532943 cites W2007856475 @default.
• W2100532943 cites W2014285290 @default.
• W2100532943 cites W2016009760 @default.
• W2100532943 cites W2016823790 @default.
• W2100532943 cites W2020653679 @default.
• W2100532943 cites W2033566124 @default.
• W2100532943 cites W2035651599 @default.
• W2100532943 cites W2039813966 @default.
• W2100532943 cites W2040158161 @default.
• W2100532943 cites W2041021406 @default.
• W2100532943 cites W2042886827 @default.
• W2100532943 cites W2046207757 @default.
• W2100532943 cites W2048258494 @default.
• W2100532943 cites W2048579894 @default.
• W2100532943 cites W2048799837 @default.
• W2100532943 cites W2054095935 @default.
• W2100532943 cites W2071730233 @default.
• W2100532943 cites W2074860914 @default.
• W2100532943 cites W2086161655 @default.
• W2100532943 cites W2086385294 @default.
• W2100532943 cites W2088287763 @default.
• W2100532943 cites W2088540455 @default.
• W2100532943 cites W2097577343 @default.
• W2100532943 cites W2104453327 @default.
• W2100532943 cites W2107259575 @default.
• W2100532943 cites W2107313757 @default.
• W2100532943 cites W2114456249 @default.
• W2100532943 cites W2114741924 @default.
• W2100532943 cites W2117481455 @default.
• W2100532943 cites W2117978109 @default.
• W2100532943 cites W2121522599 @default.
• W2100532943 cites W2128792295 @default.
• W2100532943 cites W2141512146 @default.
• W2100532943 cites W2142216180 @default.
• W2100532943 cites W2142226770 @default.
• W2100532943 cites W2143638937 @default.
• W2100532943 cites W2144195294 @default.
• W2100532943 cites W2147039895 @default.
• W2100532943 cites W2165776322 @default.
• W2100532943 cites W2166028130 @default.
• W2100532943 cites W2167819926 @default.
• W2100532943 cites W2170097602 @default.
• W2100532943 cites W2321811911 @default.
• W2100532943 cites W4255057869 @default.
• W2100532943 doi "https://doi.org/10.1002/cne.21729" @default.
• W2100532943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18461607" @default.
• W2100532943 hasPublicationYear "2008" @default.
• W2100532943 type Work @default.
• W2100532943 sameAs 2100532943 @default.
• W2100532943 citedByCount "54" @default.
• W2100532943 countsByYear W21005329432013 @default.
• W2100532943 countsByYear W21005329432014 @default.
• W2100532943 countsByYear W21005329432015 @default.
• W2100532943 countsByYear W21005329432016 @default.
• W2100532943 countsByYear W21005329432017 @default.
• W2100532943 countsByYear W21005329432018 @default.
• W2100532943 countsByYear W21005329432019 @default.
• W2100532943 countsByYear W21005329432020 @default.
• W2100532943 countsByYear W21005329432021 @default.
• W2100532943 countsByYear W21005329432022 @default.
• W2100532943 countsByYear W21005329432023 @default.
• W2100532943 crossrefType "journal-article" @default.

• next