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- W2100551458 abstract "To the Editor. We read with interest the article by Hill et al1regarding proarrhythmia associated with cisapride therapy in childhood. In light of the aforementioned article and that of Schwartz et al2 demonstrating the association of a long QT interval with sudden infant death syndrome (SIDS), we feel it relevant to report our study on the effects of cisapride on QTc interval, heart rate, and rhythm in infants. One hundred sixty infants, aged 2 to 54 weeks, were enrolled for polysomnographic study. Each infant underwent continuous bipolar limb lead electrocardiography recording for 8 hours (including simultaneous oxygen saturation, electroencephalographic, thoracic respiratory movement, and nasal airflow monitoring). The infants were divided into 2 groups, those receiving cisapride therapy (minimum of 4 days) for gastroesophageal reflux (83 infants) and those on no therapy, the controls (77 infants). Exclusion criteria for enrollment included a family history or sibling with SIDS or arrhythmia, bundle branch block on electrocardiogram (ECG), concomitant use of medication known to prolong the QT interval, metabolic, and central nervous system abnormality. Serum electrolytes were not determined, as it was not merited on clinical grounds. The 8-hour ECG tracings were recorded on optical disc and reviewed digitized on screen. QT, R-R, and QTc (corrected using Bazett's formula3) intervals were measured in 3 consecutive beats at hourly intervals for 8 hours. The 24 values obtained were averaged. Furthermore, the 8-hour period was …" @default.
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- W2100551458 date "1999-04-01" @default.
- W2100551458 modified "2023-10-18" @default.
- W2100551458 title "Cisapride and Proarrhythmia in Childhood" @default.
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- W2100551458 doi "https://doi.org/10.1542/peds.103.4.856" @default.
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