FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100558103> ?p ?o ?g. }

• W2100558103 endingPage "16" @default.
• W2100558103 startingPage "3" @default.
• W2100558103 abstract "In addition to reacting with DNA base moieties, many chemical genotoxins also react with the oxygen atoms of the internucleotidic phosphodiester linkages to form phosphotriester adducts (PTEs). In view of their stability under physiological conditions, it has been suggested that PTEs may be useful biomarkers for measuring cumulative genotoxin exposure. The methodology for their determination is varied and still not completely developed but includes determination of hydrolysis products and 32P-postlabelling approaches. More recently, transalkylation and direct mass spectrometry techniques have been devised, which give extra chemical information on the structures of the PTEs. The proportion of DNA damage formed as PTEs is much greater with SN1 compared to SN2 alkylating agents, and it has been shown in DNA that the formation of PTEs is partially sequence dependent. PTEs have been considered to be refractory to repair in mammalian cells but repair mechanisms have been found in prokaryotic cells, e.g. PTEs in Escherichia coli are repaired by O6-methylguanine-DNA methyltransferase (O6-MGT or Ada protein). However, studies on in vivo persistence of PTEs in mammalian systems have not ruled out the possibility of a contribution from an active repair process for PTEs. The biological significance of PTEs is largely unstudied and unknown, although effects of PTEs on DNA polymerases, and some exo- and endonucleases have been observed. Also site-specific PTEs impair the repair processing of adjacent sites of DNA damage, which may be a biological mechanism of importance for these lesions. In this review, we will consider the analytical methods available for the determination of PTEs, their stability in vitro and in vivo, the mechanisms for their repair, their possible biological significance and their potential role as biomarkers in human molecular epidemiology studies." @default.
• W2100558103 created "2016-06-24" @default.
• W2100558103 creator A5007042251 @default.
• W2100558103 creator A5040828120 @default.
• W2100558103 creator A5052471889 @default.
• W2100558103 date "2009-11-17" @default.
• W2100558103 modified "2023-10-16" @default.
• W2100558103 title "Phosphotriester adducts (PTEs): DNA's overlooked lesion" @default.
• W2100558103 cites W1468793626 @default.
• W2100558103 cites W1497225274 @default.
• W2100558103 cites W1508567601 @default.
• W2100558103 cites W1563674780 @default.
• W2100558103 cites W1590403328 @default.
• W2100558103 cites W1598935111 @default.
• W2100558103 cites W1822498950 @default.
• W2100558103 cites W1935311510 @default.
• W2100558103 cites W1967199525 @default.
• W2100558103 cites W1971470197 @default.
• W2100558103 cites W1972021276 @default.
• W2100558103 cites W1974247231 @default.
• W2100558103 cites W1976247417 @default.
• W2100558103 cites W1979417067 @default.
• W2100558103 cites W1982615224 @default.
• W2100558103 cites W1983274728 @default.
• W2100558103 cites W1986010259 @default.
• W2100558103 cites W1986233356 @default.
• W2100558103 cites W1987580232 @default.
• W2100558103 cites W1989462050 @default.
• W2100558103 cites W1992105614 @default.
• W2100558103 cites W1994914937 @default.
• W2100558103 cites W1997335851 @default.
• W2100558103 cites W1998793913 @default.
• W2100558103 cites W2002822987 @default.
• W2100558103 cites W2004697593 @default.
• W2100558103 cites W2008286114 @default.
• W2100558103 cites W2009530877 @default.
• W2100558103 cites W2011510682 @default.
• W2100558103 cites W2011648634 @default.
• W2100558103 cites W2012911939 @default.
• W2100558103 cites W2015544372 @default.
• W2100558103 cites W2018312020 @default.
• W2100558103 cites W2018803512 @default.
• W2100558103 cites W2019065642 @default.
• W2100558103 cites W2020217055 @default.
• W2100558103 cites W2021960562 @default.
• W2100558103 cites W2022713259 @default.
• W2100558103 cites W2025956351 @default.
• W2100558103 cites W2026178154 @default.
• W2100558103 cites W2026704426 @default.
• W2100558103 cites W2026964477 @default.
• W2100558103 cites W2028397180 @default.
• W2100558103 cites W2028791115 @default.
• W2100558103 cites W2029033264 @default.
• W2100558103 cites W2030219831 @default.
• W2100558103 cites W2031640618 @default.
• W2100558103 cites W2032345984 @default.
• W2100558103 cites W2033148267 @default.
• W2100558103 cites W2035985317 @default.
• W2100558103 cites W2036041743 @default.
• W2100558103 cites W2037321190 @default.
• W2100558103 cites W2041001285 @default.
• W2100558103 cites W2042765650 @default.
• W2100558103 cites W2043930674 @default.
• W2100558103 cites W2044859562 @default.
• W2100558103 cites W2045193252 @default.
• W2100558103 cites W2050327614 @default.
• W2100558103 cites W2053457966 @default.
• W2100558103 cites W2053695785 @default.
• W2100558103 cites W2055581923 @default.
• W2100558103 cites W2055708188 @default.
• W2100558103 cites W2058345355 @default.
• W2100558103 cites W2060722644 @default.
• W2100558103 cites W2061607190 @default.
• W2100558103 cites W2065782985 @default.
• W2100558103 cites W2065845336 @default.
• W2100558103 cites W2066331982 @default.
• W2100558103 cites W2071639768 @default.
• W2100558103 cites W2072083287 @default.
• W2100558103 cites W2072454210 @default.
• W2100558103 cites W2074412585 @default.
• W2100558103 cites W2074964515 @default.
• W2100558103 cites W2082205587 @default.
• W2100558103 cites W2083021359 @default.
• W2100558103 cites W2085089897 @default.
• W2100558103 cites W2085212704 @default.
• W2100558103 cites W2088351463 @default.
• W2100558103 cites W2090762856 @default.
• W2100558103 cites W2091710882 @default.
• W2100558103 cites W2097630801 @default.
• W2100558103 cites W2097761612 @default.
• W2100558103 cites W2098753224 @default.
• W2100558103 cites W2099323798 @default.
• W2100558103 cites W2100308041 @default.
• W2100558103 cites W2108255671 @default.
• W2100558103 cites W2111284995 @default.
• W2100558103 cites W2114058057 @default.
• W2100558103 cites W2117348158 @default.
• W2100558103 cites W2132304035 @default.

• next