FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100561268> ?p ?o ?g. }

• W2100561268 endingPage "2273" @default.
• W2100561268 startingPage "2268" @default.
• W2100561268 abstract "Expression of the glutathione S -transferase, GSTP1, is associated with phase 1 detoxification of the products of oxidative stress. Recently, GSTP1 expression has been implicated in the regulation of cell proliferation and apoptosis through direct interaction with the c-Jun N-terminal kinase, (JNK). GSTP1 is polymorphic and allelic variants have been associated with disease susceptibility and clinical outcome. However, the influence of GSTP1 alleles on proliferation and apoptosis has not been studied previously. To investigate this, we have examined the effects of inducible expression of wild-type GSTP1*A and mutant GSTP1*C haplotypes on cell proliferation and apoptosis in NIH3T3 fibroblasts. Cells expressing GSTP1*A displayed increased doubling times and a delayed G 1 –S phase transition compared with cells expressing GSTP1*C . Both GSTP1*A and GSTP1*C haplotypes protected cells from undergoing apoptosis when exposed to oxidative stress. However, analysis of JNK status revealed that only GSTP1*C expression led to a reduction in JNK activity compared with GSTP1*A -expressing cells and non-induced cells. We further examined the effect of GSTP1 alleles on colony-forming efficiency (CFE) in soft agar following exposure to oxidative stress and found that GSTP1*A -expressing clones had increased CFE compared with non-induced and GSTP1*C -expressing clones. Our data suggest that GSTP1 alleles have differential effects on proliferation and apoptosis; GSTP1*A reduces cellular proliferation and protects against apoptosis through a JNK-independent mechanism. In contrast, GSTP1*C does not influence cellular proliferation but protects cells from apoptosis through JNK-mediated mechanisms." @default.
• W2100561268 created "2016-06-24" @default.
• W2100561268 creator A5000113898 @default.
• W2100561268 creator A5019584664 @default.
• W2100561268 creator A5031394822 @default.
• W2100561268 creator A5058886578 @default.
• W2100561268 creator A5074849352 @default.
• W2100561268 creator A5084718162 @default.
• W2100561268 date "2007-09-07" @default.
• W2100561268 modified "2023-09-26" @default.
• W2100561268 title "Differential effects of glutathione S-transferase pi (GSTP1) haplotypes on cell proliferation and apoptosis" @default.
• W2100561268 cites W1798654584 @default.
• W2100561268 cites W1900293315 @default.
• W2100561268 cites W1974621673 @default.
• W2100561268 cites W1976385326 @default.
• W2100561268 cites W1984736110 @default.
• W2100561268 cites W1994333939 @default.
• W2100561268 cites W1995584424 @default.
• W2100561268 cites W2021477435 @default.
• W2100561268 cites W2031333531 @default.
• W2100561268 cites W2031657899 @default.
• W2100561268 cites W2036263699 @default.
• W2100561268 cites W2046750894 @default.
• W2100561268 cites W2059635174 @default.
• W2100561268 cites W2063919832 @default.
• W2100561268 cites W2088113277 @default.
• W2100561268 cites W2106759295 @default.
• W2100561268 cites W2106867819 @default.
• W2100561268 cites W2112440852 @default.
• W2100561268 cites W2116729177 @default.
• W2100561268 cites W2122190005 @default.
• W2100561268 cites W2136046634 @default.
• W2100561268 cites W2150081412 @default.
• W2100561268 cites W2150115597 @default.
• W2100561268 cites W2188965485 @default.
• W2100561268 cites W2480484651 @default.
• W2100561268 cites W3198355920 @default.
• W2100561268 cites W659403336 @default.
• W2100561268 doi "https://doi.org/10.1093/carcin/bgm135" @default.
• W2100561268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17557902" @default.
• W2100561268 hasPublicationYear "2007" @default.
• W2100561268 type Work @default.
• W2100561268 sameAs 2100561268 @default.
• W2100561268 citedByCount "79" @default.
• W2100561268 countsByYear W21005612682012 @default.
• W2100561268 countsByYear W21005612682013 @default.
• W2100561268 countsByYear W21005612682014 @default.
• W2100561268 countsByYear W21005612682015 @default.
• W2100561268 countsByYear W21005612682016 @default.
• W2100561268 countsByYear W21005612682017 @default.
• W2100561268 countsByYear W21005612682018 @default.
• W2100561268 countsByYear W21005612682019 @default.
• W2100561268 countsByYear W21005612682020 @default.
• W2100561268 countsByYear W21005612682021 @default.
• W2100561268 countsByYear W21005612682022 @default.
• W2100561268 crossrefType "journal-article" @default.
• W2100561268 hasAuthorship W2100561268A5000113898 @default.
• W2100561268 hasAuthorship W2100561268A5019584664 @default.
• W2100561268 hasAuthorship W2100561268A5031394822 @default.
• W2100561268 hasAuthorship W2100561268A5058886578 @default.
• W2100561268 hasAuthorship W2100561268A5074849352 @default.
• W2100561268 hasAuthorship W2100561268A5084718162 @default.
• W2100561268 hasBestOaLocation W21005612681 @default.
• W2100561268 hasConcept C153911025 @default.
• W2100561268 hasConcept C181199279 @default.
• W2100561268 hasConcept C190283241 @default.
• W2100561268 hasConcept C2776151105 @default.
• W2100561268 hasConcept C2776907368 @default.
• W2100561268 hasConcept C2780122483 @default.
• W2100561268 hasConcept C502942594 @default.
• W2100561268 hasConcept C538909803 @default.
• W2100561268 hasConcept C54355233 @default.
• W2100561268 hasConcept C55493867 @default.
• W2100561268 hasConcept C62112901 @default.
• W2100561268 hasConcept C86803240 @default.
• W2100561268 hasConceptScore W2100561268C153911025 @default.
• W2100561268 hasConceptScore W2100561268C181199279 @default.
• W2100561268 hasConceptScore W2100561268C190283241 @default.
• W2100561268 hasConceptScore W2100561268C2776151105 @default.
• W2100561268 hasConceptScore W2100561268C2776907368 @default.
• W2100561268 hasConceptScore W2100561268C2780122483 @default.
• W2100561268 hasConceptScore W2100561268C502942594 @default.
• W2100561268 hasConceptScore W2100561268C538909803 @default.
• W2100561268 hasConceptScore W2100561268C54355233 @default.
• W2100561268 hasConceptScore W2100561268C55493867 @default.
• W2100561268 hasConceptScore W2100561268C62112901 @default.
• W2100561268 hasConceptScore W2100561268C86803240 @default.
• W2100561268 hasIssue "11" @default.
• W2100561268 hasLocation W21005612681 @default.
• W2100561268 hasLocation W21005612682 @default.
• W2100561268 hasOpenAccess W2100561268 @default.
• W2100561268 hasPrimaryLocation W21005612681 @default.
• W2100561268 hasRelatedWork W2054074810 @default.
• W2100561268 hasRelatedWork W2070403597 @default.
• W2100561268 hasRelatedWork W2157997481 @default.
• W2100561268 hasRelatedWork W2167818195 @default.
• W2100561268 hasRelatedWork W2174438116 @default.
• W2100561268 hasRelatedWork W2404520989 @default.

• next