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• W2100565863 abstract "Abstract The unilateral ureteral obstruction (UUO) model of renal injury in rat is characterized by nuclear factor κB (NF-κB) activation and tumour necrosis factor α (TNF-α) production, which induces apoptosis via activation of caspase 8 resulting in cell death. Curcumin, the major component found in turmeric spice, has been reported to provide protection against fibrosis and apoptosis elicited by UUO. This study examined the effects of a turmeric-based diet (5% w/w) on the apoptotic pathway induced by UUO in rats after 30 days of ligation. Administration of a turmeric-based diet demonstrated a significant decrease (P &lt; 0.05) in mRNA expression of TNF-α and caspase 8, but not NF-κB, expression, which may contribute to the protective role of the turmeric-based diet. We conclude that a turmeric-based diet can delay apoptosis without modulating NF-κB, so as not to sensitize the mesangial cells to the apoptotic stimuli." @default.
• W2100565863 created "2016-06-24" @default.
• W2100565863 creator A5023148499 @default.
• W2100565863 creator A5041434544 @default.
• W2100565863 creator A5078725141 @default.
• W2100565863 date "2008-01-01" @default.
• W2100565863 modified "2023-09-23" @default.
• W2100565863 title "Turmeric-based diet can delay apoptosis without modulating NF-κB in unilateral ureteral obstruction in rats" @default.
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• W2100565863 doi "https://doi.org/10.1211/jpp.60.1.0011" @default.
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