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• W2100585044 abstract "Candida albicans is a common, harmless yeast in the human digestive tract that also causes severe systemic fungal infection in hospitalized patients. Its cell-wall surface displays a unique glycolipid called phospholipomannan (PLM). The ability of PLM to stimulate tumor necrosis factor (TNF)-alpha production by J774 mouse cells correlates with the activation of nuclear factor (NF)-kappaB. We examined the involvement of Toll-like receptors (TLRs) in PLM-dependent stimulation. Compared with wild-type cells, which produced large amounts of TNF-alpha after incubation with PLM, the deletion of the TLR4 and TLR6 genes led to a limited alteration of the PLM-induced response. Deletion of the TLR2 gene completely abolished the cell response. Surface expression of PLM is a phylogenic trait of C. albicans, and the recognition of PLM by TLRs, together with the unique pathogenic potential of C. albicans, suggests that this molecule may be a member of the pathogen-associated molecular pattern family." @default.
• W2100585044 created "2016-06-24" @default.
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• W2100585044 date "2003-07-01" @default.
• W2100585044 modified "2023-09-28" @default.
• W2100585044 title "<i>Candida albicans</i>Phospholipomannan Is Sensed through Toll‐Like Receptors" @default.
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• W2100585044 doi "https://doi.org/10.1086/375784" @default.
• W2100585044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12825186" @default.
• W2100585044 hasPublicationYear "2003" @default.
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