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• W2100586710 abstract "Machupo virus (MACV) is the etiologic agent of Bolivian hemorrhagic fever (BHF). Utilizing a reverse-genetics system recently developed, we report the rescue of a rationally modified recombinant MACV containing a single mutation in the transmembrane region of the glycoprotein. Following challenge of susceptible mice, we identified a significant reduction in virulence in the novel virus. We also identified an instability leading to reversion of the single mutation to a wild-type genotype." @default.
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• W2100586710 date "2014-09-15" @default.
• W2100586710 modified "2023-10-03" @default.
• W2100586710 title "A Substitution in the Transmembrane Region of the Glycoprotein Leads to an Unstable Attenuation of Machupo Virus" @default.
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• W2100586710 doi "https://doi.org/10.1128/jvi.01007-14" @default.
• W2100586710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4178861" @default.
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