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- W2100587918 abstract "A major factor in the reduction of growth in parasitized lambs is the depression in food intake by a mechanism not yet understood. Investigation of the pattern of eating has shown that parasitized lambs have a lower (35%) cumulative intake, especially within the first hour of feeding, which return to a control level on drenching. The importance of two factors which may moderate intake depression, the activity of the ventromedial hypothalamus (VMH) and elevated cholecystokinin (CCK), were investigated. Four animals with intake depression (approximately 40% PcO.05) as a result of ccntinuous infectian with 40X1 T.colubriformirperdayfor12weekstogetherwith4controlanimalsreceived,inareplicatedlatinsquamdesignO, 1,2andrlmli.v.ofacompound (brotizolam)usedtoblockthesatietyeffectattheVMH. Intakeincreased~<O.O5)withinthefirsthouroffeedingofbsthparasitizedandcontrol animals (approximately 2.6 and 1.9 times. respectively). Four similarly infected and 4 control lambs were given varying doses of a potent antagonist of peripheral CCK action without effect on food intake. These results suggest that depression of food intake in parasitized lambs appears to involve central satiety signals and not peripheral CCK." @default.
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- W2100587918 date "1990-01-01" @default.
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- W2100587918 title "Studies on the physiological basis of appetite depression in nematode infection in sheep" @default.
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