FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100591642> ?p ?o ?g. }

• W2100591642 endingPage "2013" @default.
• W2100591642 startingPage "2004" @default.
• W2100591642 abstract "ABSTRACT Circadian (≅24-h) rhythms are governed by endogenous biochemical oscillators (clocks) that in a wide variety of organisms can be phase shifted (i.e., delayed or advanced) by brief exposure to light and changes in temperature. However, how changes in temperature reset circadian timekeeping mechanisms is not known. To begin to address this issue, we measured the effects of short-duration heat pulses on the protein and mRNA products from the Drosophila circadian clock genes period ( per ) and timeless ( tim ). Heat pulses at all times in a daily cycle elicited dramatic and rapid decreases in the levels of PER and TIM proteins. PER is sensitive to heat but not light, indicating that individual clock components can markedly differ in sensitivity to environmental stimuli. A similar resetting mechanism involving delays in the per-tim transcriptional-translational feedback loop likely underlies the observation that when heat and light signals are administered in the early night, they both evoke phase delays in behavioral rhythms. However, whereas previous studies showed that the light-induced degradation of TIM in the late night is accompanied by stable phase advances in the temporal regulation of the PER and TIM biochemical rhythms, the heat-induced degradation of PER and TIM at these times in a daily cycle results in little, if any, long-term perturbation in the cycles of these clock proteins. Rather, the initial heat-induced degradation of PER and TIM in the late night is followed by a transient and rapid increase in the speed of the PER-TIM temporal program. The net effect of these heat-induced changes results in an oscillatory mechanism with a steady-state phase similar to that of the unperturbed control situation. These findings can account for the lack of apparent steady-state shifts in Drosophila behavioral rhythms by heat pulses applied in the late night and strongly suggest that stimulus-induced changes in the speed of circadian clocks can contribute to phase-shifting responses." @default.
• W2100591642 created "2016-06-24" @default.
• W2100591642 creator A5000952292 @default.
• W2100591642 creator A5028236397 @default.
• W2100591642 creator A5059783595 @default.
• W2100591642 creator A5065935226 @default.
• W2100591642 date "1998-04-01" @default.
• W2100591642 modified "2023-10-02" @default.
• W2100591642 title "Differential Effects of Light and Heat on the <i>Drosophila</i> Circadian Clock Proteins PER and TIM" @default.
• W2100591642 cites W1589364054 @default.
• W2100591642 cites W1605372070 @default.
• W2100591642 cites W1940049677 @default.
• W2100591642 cites W1968410906 @default.
• W2100591642 cites W1969706605 @default.
• W2100591642 cites W1970785480 @default.
• W2100591642 cites W1975635900 @default.
• W2100591642 cites W1982496486 @default.
• W2100591642 cites W1986465162 @default.
• W2100591642 cites W1992749367 @default.
• W2100591642 cites W1993955938 @default.
• W2100591642 cites W1995139743 @default.
• W2100591642 cites W2005174604 @default.
• W2100591642 cites W2009139862 @default.
• W2100591642 cites W2018873867 @default.
• W2100591642 cites W2022374934 @default.
• W2100591642 cites W2024189391 @default.
• W2100591642 cites W2024339680 @default.
• W2100591642 cites W2028214516 @default.
• W2100591642 cites W2028563901 @default.
• W2100591642 cites W2030063045 @default.
• W2100591642 cites W2031165211 @default.
• W2100591642 cites W2032149289 @default.
• W2100591642 cites W2035097877 @default.
• W2100591642 cites W2035550196 @default.
• W2100591642 cites W2040142812 @default.
• W2100591642 cites W2040561723 @default.
• W2100591642 cites W2042068133 @default.
• W2100591642 cites W2043339041 @default.
• W2100591642 cites W2046290772 @default.
• W2100591642 cites W2050918140 @default.
• W2100591642 cites W2056296605 @default.
• W2100591642 cites W2056393772 @default.
• W2100591642 cites W2060138058 @default.
• W2100591642 cites W2064550220 @default.
• W2100591642 cites W2073036589 @default.
• W2100591642 cites W2084548353 @default.
• W2100591642 cites W2088347811 @default.
• W2100591642 cites W2091859064 @default.
• W2100591642 cites W2107478358 @default.
• W2100591642 cites W2117742420 @default.
• W2100591642 cites W2127777086 @default.
• W2100591642 cites W2128292564 @default.
• W2100591642 cites W2132024812 @default.
• W2100591642 cites W2132687554 @default.
• W2100591642 cites W2132689128 @default.
• W2100591642 cites W2137168344 @default.
• W2100591642 cites W2148254131 @default.
• W2100591642 cites W2163411705 @default.
• W2100591642 cites W2165113979 @default.
• W2100591642 cites W2175093343 @default.
• W2100591642 cites W2346964101 @default.
• W2100591642 doi "https://doi.org/10.1128/mcb.18.4.2004" @default.
• W2100591642 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/121430" @default.
• W2100591642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9528772" @default.
• W2100591642 hasPublicationYear "1998" @default.
• W2100591642 type Work @default.
• W2100591642 sameAs 2100591642 @default.
• W2100591642 citedByCount "98" @default.
• W2100591642 countsByYear W21005916422012 @default.
• W2100591642 countsByYear W21005916422013 @default.
• W2100591642 countsByYear W21005916422014 @default.
• W2100591642 countsByYear W21005916422015 @default.
• W2100591642 countsByYear W21005916422016 @default.
• W2100591642 countsByYear W21005916422017 @default.
• W2100591642 countsByYear W21005916422018 @default.
• W2100591642 countsByYear W21005916422019 @default.
• W2100591642 countsByYear W21005916422020 @default.
• W2100591642 countsByYear W21005916422021 @default.
• W2100591642 countsByYear W21005916422022 @default.
• W2100591642 countsByYear W21005916422023 @default.
• W2100591642 crossrefType "journal-article" @default.
• W2100591642 hasAuthorship W2100591642A5000952292 @default.
• W2100591642 hasAuthorship W2100591642A5028236397 @default.
• W2100591642 hasAuthorship W2100591642A5059783595 @default.
• W2100591642 hasAuthorship W2100591642A5065935226 @default.
• W2100591642 hasBestOaLocation W21005916422 @default.
• W2100591642 hasConcept C104317684 @default.
• W2100591642 hasConcept C121332964 @default.
• W2100591642 hasConcept C121446783 @default.
• W2100591642 hasConcept C130679736 @default.
• W2100591642 hasConcept C169760540 @default.
• W2100591642 hasConcept C2776041557 @default.
• W2100591642 hasConcept C38606739 @default.
• W2100591642 hasConcept C54355233 @default.
• W2100591642 hasConcept C86803240 @default.
• W2100591642 hasConcept C93226319 @default.
• W2100591642 hasConcept C95444343 @default.
• W2100591642 hasConcept C97355855 @default.

• next