FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100602395> ?p ?o ?g. }

• W2100602395 endingPage "511" @default.
• W2100602395 startingPage "506" @default.
• W2100602395 abstract "To test whether norepinephrine (NOR) affects tissue microcirculation and impairs plasma-to-tissue equilibration of antimicrobial agents.Eight healthy male volunteers were enrolled to an analyst-blinded, randomized, two-period two-sequence crossover study. A single intravenous dose of 2 g of cefpirome was administered simultaneously with starting a continuous infusion of NOR (0.16 microg/kg per min) or placebo (PL) over 180 min. The microdialysis technique was used for the assessment of unbound cefpirome concentrations in skeletal muscle tissue and subcutaneous adipose tissue. Free plasma concentrations were related to corresponding tissue concentrations. Haemodynamics were determined by the measurement of mean arterial blood pressure (MAP), heart rate and forearm blood flow (FBF).Area under the concentration-time-curve (AUC) values of cefpirome for interstitium and plasma were not significantly different between the PL and NOR groups (P > 0.47). Tissue penetration of cefpirome as described by the ratios of the AUCs from 0 to 180 min for tissue to the AUC values for plasma were 0.81 +/- 0.34 for the PL group and 0.80 +/- 0.26 for the NOR group (P > 0.05). Baseline values of MAP, heart rate and FBF were not significantly different between study days. MAP increased significantly following NOR administration from 73.3 +/- 3.5 mmHg at baseline to 94.0 +/- 5.2 mmHg during infusion (P = 0.017). NOR exerted no significant effects on FBF.We have shown that intravenous administration of NOR does not exert a significant effect on peripheral blood flow and tissue penetration of cefpirome in healthy men. This might be attributed to systemic regulatory mechanisms, which probably fully compensate for major changes in blood flow in peripheral tissues." @default.
• W2100602395 created "2016-06-24" @default.
• W2100602395 creator A5002627490 @default.
• W2100602395 creator A5019765272 @default.
• W2100602395 creator A5022599009 @default.
• W2100602395 creator A5049331182 @default.
• W2100602395 creator A5068765901 @default.
• W2100602395 creator A5071212354 @default.
• W2100602395 creator A5076180813 @default.
• W2100602395 creator A5076953099 @default.
• W2100602395 creator A5081309605 @default.
• W2100602395 date "2004-02-12" @default.
• W2100602395 modified "2023-10-16" @default.
• W2100602395 title "Effect of norepinephrine on cefpirome tissue concentrations in healthy subjects" @default.
• W2100602395 cites W1538914313 @default.
• W2100602395 cites W1790654406 @default.
• W2100602395 cites W1964655784 @default.
• W2100602395 cites W1981522743 @default.
• W2100602395 cites W1988957995 @default.
• W2100602395 cites W1992203366 @default.
• W2100602395 cites W1992426844 @default.
• W2100602395 cites W1997635642 @default.
• W2100602395 cites W2002383988 @default.
• W2100602395 cites W2004870042 @default.
• W2100602395 cites W2022089033 @default.
• W2100602395 cites W2046935214 @default.
• W2100602395 cites W2046946927 @default.
• W2100602395 cites W2058680926 @default.
• W2100602395 cites W2063281374 @default.
• W2100602395 cites W2064710851 @default.
• W2100602395 cites W2078397507 @default.
• W2100602395 cites W2091046841 @default.
• W2100602395 cites W2108289212 @default.
• W2100602395 cites W2118735797 @default.
• W2100602395 cites W2129927379 @default.
• W2100602395 cites W2134850367 @default.
• W2100602395 cites W2153802091 @default.
• W2100602395 cites W2162232790 @default.
• W2100602395 cites W2224737570 @default.
• W2100602395 cites W2488847832 @default.
• W2100602395 cites W78888789 @default.
• W2100602395 doi "https://doi.org/10.1093/jac/dkh111" @default.
• W2100602395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14749346" @default.
• W2100602395 hasPublicationYear "2004" @default.
• W2100602395 type Work @default.
• W2100602395 sameAs 2100602395 @default.
• W2100602395 citedByCount "8" @default.
• W2100602395 countsByYear W21006023952012 @default.
• W2100602395 countsByYear W21006023952014 @default.
• W2100602395 countsByYear W21006023952015 @default.
• W2100602395 countsByYear W21006023952019 @default.
• W2100602395 crossrefType "journal-article" @default.
• W2100602395 hasAuthorship W2100602395A5002627490 @default.
• W2100602395 hasAuthorship W2100602395A5019765272 @default.
• W2100602395 hasAuthorship W2100602395A5022599009 @default.
• W2100602395 hasAuthorship W2100602395A5049331182 @default.
• W2100602395 hasAuthorship W2100602395A5068765901 @default.
• W2100602395 hasAuthorship W2100602395A5071212354 @default.
• W2100602395 hasAuthorship W2100602395A5076180813 @default.
• W2100602395 hasAuthorship W2100602395A5076953099 @default.
• W2100602395 hasAuthorship W2100602395A5081309605 @default.
• W2100602395 hasBestOaLocation W21006023951 @default.
• W2100602395 hasConcept C126322002 @default.
• W2100602395 hasConcept C141071460 @default.
• W2100602395 hasConcept C142724271 @default.
• W2100602395 hasConcept C185592680 @default.
• W2100602395 hasConcept C204787440 @default.
• W2100602395 hasConcept C27081682 @default.
• W2100602395 hasConcept C2776452961 @default.
• W2100602395 hasConcept C2777300098 @default.
• W2100602395 hasConcept C2777457247 @default.
• W2100602395 hasConcept C2777953023 @default.
• W2100602395 hasConcept C2778514504 @default.
• W2100602395 hasConcept C2779631663 @default.
• W2100602395 hasConcept C42219234 @default.
• W2100602395 hasConcept C50156730 @default.
• W2100602395 hasConcept C501593827 @default.
• W2100602395 hasConcept C529278444 @default.
• W2100602395 hasConcept C55493867 @default.
• W2100602395 hasConcept C71924100 @default.
• W2100602395 hasConcept C76318530 @default.
• W2100602395 hasConcept C84393581 @default.
• W2100602395 hasConcept C87813604 @default.
• W2100602395 hasConcept C94665300 @default.
• W2100602395 hasConceptScore W2100602395C126322002 @default.
• W2100602395 hasConceptScore W2100602395C141071460 @default.
• W2100602395 hasConceptScore W2100602395C142724271 @default.
• W2100602395 hasConceptScore W2100602395C185592680 @default.
• W2100602395 hasConceptScore W2100602395C204787440 @default.
• W2100602395 hasConceptScore W2100602395C27081682 @default.
• W2100602395 hasConceptScore W2100602395C2776452961 @default.
• W2100602395 hasConceptScore W2100602395C2777300098 @default.
• W2100602395 hasConceptScore W2100602395C2777457247 @default.
• W2100602395 hasConceptScore W2100602395C2777953023 @default.
• W2100602395 hasConceptScore W2100602395C2778514504 @default.
• W2100602395 hasConceptScore W2100602395C2779631663 @default.
• W2100602395 hasConceptScore W2100602395C42219234 @default.
• W2100602395 hasConceptScore W2100602395C50156730 @default.

• next