FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100620173> ?p ?o ?g. }

• W2100620173 endingPage "H485" @default.
• W2100620173 startingPage "H476" @default.
• W2100620173 abstract "Large-conductance Ca 2+ -activated K + (BK) channels are composed of pore-forming α-subunits and accessory β 1 -subunits that modulate Ca 2+ sensitivity. BK channels regulate arterial myogenic tone and renal Na + clearance/K + reabsorption. Previous studies using indirect or short-term blood pressure measurements found that BK channel β 1 -subunit knockout (BK β 1 -KO) mice were hypertensive. We evaluated 24-h mean arterial pressure (MAP) and heart rate in BK β 1 -KO mice using radiotelemetry. BK β 1 -KO mice did not have a higher 24-h average MAP when compared with wild-type (WT) mice, although MAP was ∼10 mmHg higher at night. The dose-dependent peak declines in MAP by nifedipine were only slightly larger in BK β 1 -KO mice. In BK β 1 -KO mice, giving 1% NaCl to mice to drink for 7 days caused a transient (5 days) elevation of MAP (∼5 mmHg); MAP returned to pre-saline levels by day 6. BK β 1 -KO mesenteric arteries in vitro demonstrated diminished contractile responses to paxilline, increased reactivity to Bay K 8644 and norepinephrine (NE), and maintained relaxation to isoproterenol. Paxilline and Bay K 8644 did not constrict WT or BK β 1 -KO mesenteric veins (MV). BK β 1 -subunits are not expressed in MV. The results indicate that BK β 1 -KO mice are not hypertensive on normal or high-salt intake. BK channel deficiency increases arterial reactivity to NE and L-type Ca 2+ channel function in vitro, but the L-type Ca 2+ channel modulation of MAP is not altered in BK β 1 -KO mice. BK and L-type Ca 2+ channels do not modulate murine venous tone. It appears that selective loss of BK channel function in arteries only is not sufficient to cause sustained hypertension." @default.
• W2100620173 created "2016-06-24" @default.
• W2100620173 creator A5053076079 @default.
• W2100620173 creator A5062804384 @default.
• W2100620173 creator A5083289271 @default.
• W2100620173 creator A5085256874 @default.
• W2100620173 date "2011-02-01" @default.
• W2100620173 modified "2023-09-25" @default.
• W2100620173 title "Large-conductance Ca²⁺-activated K⁺channel β₁-subunit knockout mice are not hypertensive" @default.
• W2100620173 cites W1519345480 @default.
• W2100620173 cites W1525092122 @default.
• W2100620173 cites W1701982621 @default.
• W2100620173 cites W1965021019 @default.
• W2100620173 cites W1972096487 @default.
• W2100620173 cites W1976087935 @default.
• W2100620173 cites W1979889928 @default.
• W2100620173 cites W1981964819 @default.
• W2100620173 cites W1982196463 @default.
• W2100620173 cites W1992604992 @default.
• W2100620173 cites W1994493389 @default.
• W2100620173 cites W2020169158 @default.
• W2100620173 cites W2025810352 @default.
• W2100620173 cites W2026089352 @default.
• W2100620173 cites W2039658671 @default.
• W2100620173 cites W2039679841 @default.
• W2100620173 cites W2050296008 @default.
• W2100620173 cites W2057448799 @default.
• W2100620173 cites W2061193289 @default.
• W2100620173 cites W2068034752 @default.
• W2100620173 cites W2075080304 @default.
• W2100620173 cites W2083196281 @default.
• W2100620173 cites W2084042223 @default.
• W2100620173 cites W2086875100 @default.
• W2100620173 cites W2104933421 @default.
• W2100620173 cites W2106475006 @default.
• W2100620173 cites W2106904241 @default.
• W2100620173 cites W2110993458 @default.
• W2100620173 cites W2112827709 @default.
• W2100620173 cites W2114427720 @default.
• W2100620173 cites W2116388134 @default.
• W2100620173 cites W2121399492 @default.
• W2100620173 cites W2125632358 @default.
• W2100620173 cites W2126046035 @default.
• W2100620173 cites W2132053765 @default.
• W2100620173 cites W2134417114 @default.
• W2100620173 cites W2146166349 @default.
• W2100620173 cites W2146300757 @default.
• W2100620173 cites W2149483794 @default.
• W2100620173 cites W2149635665 @default.
• W2100620173 cites W2151524400 @default.
• W2100620173 cites W2162526763 @default.
• W2100620173 cites W2164052170 @default.
• W2100620173 cites W2164566530 @default.
• W2100620173 cites W2178233651 @default.
• W2100620173 cites W2324096761 @default.
• W2100620173 cites W65468009 @default.
• W2100620173 doi "https://doi.org/10.1152/ajpheart.00975.2010" @default.
• W2100620173 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3044058" @default.
• W2100620173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21131476" @default.
• W2100620173 hasPublicationYear "2011" @default.
• W2100620173 type Work @default.
• W2100620173 sameAs 2100620173 @default.
• W2100620173 citedByCount "41" @default.
• W2100620173 countsByYear W21006201732012 @default.
• W2100620173 countsByYear W21006201732013 @default.
• W2100620173 countsByYear W21006201732014 @default.
• W2100620173 countsByYear W21006201732015 @default.
• W2100620173 countsByYear W21006201732016 @default.
• W2100620173 countsByYear W21006201732017 @default.
• W2100620173 countsByYear W21006201732018 @default.
• W2100620173 countsByYear W21006201732019 @default.
• W2100620173 countsByYear W21006201732020 @default.
• W2100620173 crossrefType "journal-article" @default.
• W2100620173 hasAuthorship W2100620173A5053076079 @default.
• W2100620173 hasAuthorship W2100620173A5062804384 @default.
• W2100620173 hasAuthorship W2100620173A5083289271 @default.
• W2100620173 hasAuthorship W2100620173A5085256874 @default.
• W2100620173 hasBestOaLocation W21006201732 @default.
• W2100620173 hasConcept C126322002 @default.
• W2100620173 hasConcept C134018914 @default.
• W2100620173 hasConcept C185592680 @default.
• W2100620173 hasConcept C2779066535 @default.
• W2100620173 hasConcept C2779961880 @default.
• W2100620173 hasConcept C2780091579 @default.
• W2100620173 hasConcept C519063684 @default.
• W2100620173 hasConcept C56906281 @default.
• W2100620173 hasConcept C61144316 @default.
• W2100620173 hasConcept C71924100 @default.
• W2100620173 hasConcept C83743174 @default.
• W2100620173 hasConcept C84393581 @default.
• W2100620173 hasConcept C86803240 @default.
• W2100620173 hasConceptScore W2100620173C126322002 @default.
• W2100620173 hasConceptScore W2100620173C134018914 @default.
• W2100620173 hasConceptScore W2100620173C185592680 @default.
• W2100620173 hasConceptScore W2100620173C2779066535 @default.
• W2100620173 hasConceptScore W2100620173C2779961880 @default.
• W2100620173 hasConceptScore W2100620173C2780091579 @default.
• W2100620173 hasConceptScore W2100620173C519063684 @default.

• next