Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100632795> ?p ?o ?g. }
- W2100632795 endingPage "246" @default.
- W2100632795 startingPage "237" @default.
- W2100632795 abstract "Blocking the T‐cell adhesion signal from intercellular adhesion molecule‐1/leukocyte function‐associated antigen‐1 interactions (Signal‐2) can suppress the progression of autoimmune diseases (i.e. type‐1 diabetes, psoriasis) and prevent allograph rejection. In this study, we determined the active region(s) of cLAB.L peptide [cyclo(1,12)Pen‐ITDGEATDSGC] by synthesizing and evaluating the biologic activity of hexapeptides in inhibiting T‐cell adhesion. A new heterotypic T‐cell adhesion assay was also developed to provide a model for the T‐cell adhesion process during lung inflammation. Two hexapeptides, ITDGEA and DGEATD, were found to be more active than the other linear hexapeptides. The cyclic derivative of ITDGEA [i.e. cyclo(1,6)ITDGEA] has similar activity than the parent linear peptide and has lower activity than cLAB.L peptide. Computational‐binding experiments were carried out to explain the possible mechanism of binding of these peptides to intercellular adhesion molecule‐1. Both ITDGEA and DGEATD bind the same site on intercellular adhesion molecule‐1 and they interact with the Gln34 and Gln73 residues on D1 of intercellular adhesion molecule‐1. In the future, more potent derivatives of cyclo(1,6)ITDGEA will be designed by utilizing structural and binding studies of the peptide to intercellular adhesion molecule‐1. The heterotypic T‐cell adhesion to Calu‐3 will also be used as another assay to evaluate the selectivity of the designed peptides." @default.
- W2100632795 created "2016-06-24" @default.
- W2100632795 creator A5003956897 @default.
- W2100632795 creator A5031922505 @default.
- W2100632795 creator A5036261931 @default.
- W2100632795 creator A5039765640 @default.
- W2100632795 creator A5045061541 @default.
- W2100632795 creator A5048913465 @default.
- W2100632795 creator A5062574786 @default.
- W2100632795 creator A5082223478 @default.
- W2100632795 date "2007-08-10" @default.
- W2100632795 modified "2023-10-06" @default.
- W2100632795 title "Sequence Recognition of ?-LFA-1-derived Peptides by ICAM-1 Cell Receptors: Inhibitors of T-cell Adhesion" @default.
- W2100632795 cites W1487295185 @default.
- W2100632795 cites W1503657227 @default.
- W2100632795 cites W1601968547 @default.
- W2100632795 cites W1621209507 @default.
- W2100632795 cites W169876379 @default.
- W2100632795 cites W1971204327 @default.
- W2100632795 cites W2004570679 @default.
- W2100632795 cites W2006657990 @default.
- W2100632795 cites W2016031883 @default.
- W2100632795 cites W2022431638 @default.
- W2100632795 cites W2028146382 @default.
- W2100632795 cites W2034234555 @default.
- W2100632795 cites W2034585843 @default.
- W2100632795 cites W2036055423 @default.
- W2100632795 cites W2039044366 @default.
- W2100632795 cites W2039805883 @default.
- W2100632795 cites W2043781898 @default.
- W2100632795 cites W2044163981 @default.
- W2100632795 cites W2046544104 @default.
- W2100632795 cites W2050681882 @default.
- W2100632795 cites W2054894258 @default.
- W2100632795 cites W2056587589 @default.
- W2100632795 cites W2058600606 @default.
- W2100632795 cites W2060758965 @default.
- W2100632795 cites W2061826103 @default.
- W2100632795 cites W2063559096 @default.
- W2100632795 cites W2068468264 @default.
- W2100632795 cites W2081679746 @default.
- W2100632795 cites W2086316973 @default.
- W2100632795 cites W2095732393 @default.
- W2100632795 cites W2096234619 @default.
- W2100632795 cites W2097877636 @default.
- W2100632795 cites W2101811073 @default.
- W2100632795 cites W2105778209 @default.
- W2100632795 cites W2107553760 @default.
- W2100632795 cites W2110483286 @default.
- W2100632795 cites W2122822622 @default.
- W2100632795 cites W2128469372 @default.
- W2100632795 cites W2134450176 @default.
- W2100632795 cites W2151457141 @default.
- W2100632795 cites W2152976783 @default.
- W2100632795 cites W2153342471 @default.
- W2100632795 cites W2160378662 @default.
- W2100632795 cites W2165778391 @default.
- W2100632795 cites W2169638885 @default.
- W2100632795 cites W3021977805 @default.
- W2100632795 cites W309899471 @default.
- W2100632795 cites W326603707 @default.
- W2100632795 doi "https://doi.org/10.1111/j.1747-0285.2007.00549.x" @default.
- W2100632795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17718718" @default.
- W2100632795 hasPublicationYear "2007" @default.
- W2100632795 type Work @default.
- W2100632795 sameAs 2100632795 @default.
- W2100632795 citedByCount "13" @default.
- W2100632795 countsByYear W21006327952012 @default.
- W2100632795 countsByYear W21006327952014 @default.
- W2100632795 countsByYear W21006327952018 @default.
- W2100632795 countsByYear W21006327952020 @default.
- W2100632795 countsByYear W21006327952022 @default.
- W2100632795 countsByYear W21006327952023 @default.
- W2100632795 crossrefType "journal-article" @default.
- W2100632795 hasAuthorship W2100632795A5003956897 @default.
- W2100632795 hasAuthorship W2100632795A5031922505 @default.
- W2100632795 hasAuthorship W2100632795A5036261931 @default.
- W2100632795 hasAuthorship W2100632795A5039765640 @default.
- W2100632795 hasAuthorship W2100632795A5045061541 @default.
- W2100632795 hasAuthorship W2100632795A5048913465 @default.
- W2100632795 hasAuthorship W2100632795A5062574786 @default.
- W2100632795 hasAuthorship W2100632795A5082223478 @default.
- W2100632795 hasConcept C122871604 @default.
- W2100632795 hasConcept C134659918 @default.
- W2100632795 hasConcept C1491633281 @default.
- W2100632795 hasConcept C16224149 @default.
- W2100632795 hasConcept C170493617 @default.
- W2100632795 hasConcept C178790620 @default.
- W2100632795 hasConcept C185592680 @default.
- W2100632795 hasConcept C185946421 @default.
- W2100632795 hasConcept C2779281246 @default.
- W2100632795 hasConcept C2909375385 @default.
- W2100632795 hasConcept C55493867 @default.
- W2100632795 hasConcept C79879829 @default.
- W2100632795 hasConcept C84416704 @default.
- W2100632795 hasConcept C85789140 @default.
- W2100632795 hasConcept C86803240 @default.
- W2100632795 hasConcept C95444343 @default.