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• W2100639395 abstract "We have found that sera from humans with Chagas' disease and Rhesus monkeys infected with Trypanosoma cruzi contain IgM and IgG antibodies, which react with structures in a variety of connective tissues. These antibodies react with laminin but not with various other purified connective tissue components like collagen types I, III, IV, and V, fibronectin, heparan sulfate (BM-1) proteoglycan, or chondronectin. The tissue-reacting antibodies were isolated by absorption to a laminin-Sepharose column. The bound fraction contained all the tissue-reacting antibodies. These antibodies strongly stained trypomastigotes and amastigotes, but weakly stained epimastigotes. These studies show that sera from T. cruzi-infected primates contain antilaminin antibodies, which may be produced by those host in response to a laminin-like molecule present in the parasite." @default.
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• W2100639395 date "1982-04-01" @default.
• W2100639395 modified "2023-10-16" @default.
• W2100639395 title "Antibodies to laminin in Chagas' disease." @default.
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• W2100639395 doi "https://doi.org/10.1084/jem.155.4.1161" @default.
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