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• W2100639544 abstract "To characterize clinicopathological and familial features of early-onset colorectal cancer (CRC) and compare features of tumors with and without microsatellite instability (MSI).Forty-five patients with CRC aged 45 or younger were included in the study. Clinical information, a three-generation family history, and tumor samples were obtained. MSI status was analyzed and mismatch repair genes were examined in the MSI families. Tumors were included in a tissue microarray and an immunohistochemical study was carried out with a panel of selected antibodies.Early onset CRC is characterized by advanced stage at diagnosis, right colon location, low-grade of differentiation, mucin production, and presence of polyps. Hereditary forms represent at least 21% of cases. Eighty-one percent of patients who died during follow-up showed a lack of expression of cyclin E, which could be a marker of poor prognosis. beta-catenin expression was normal in a high percentage of tumors.Early-onset CRC has an important familial component, with a high proportion of tumors showing microsatellite stable. Cyclin E might be a poor prognosis factor." @default.
• W2100639544 created "2016-06-24" @default.
• W2100639544 creator A5004033411 @default.
• W2100639544 date "2010-01-01" @default.
• W2100639544 modified "2023-10-03" @default.
• W2100639544 title "Approach to early-onset colorectal cancer: Clinicopathological, familial, molecular and immunohistochemical characteristics" @default.
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• W2100639544 doi "https://doi.org/10.3748/wjg.v16.i29.3697" @default.
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