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• W2100661426 endingPage "799" @default.
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• W2100661426 abstract "The central stalk of the ATP synthase is an elongated hetero-oligomeric structure providing a physical connection between the catalytic sites in F 1 and the proton translocation channel in F 0 for energy transduction between the two subdomains. The shape of the central stalk and relevance to energy coupling are essentially the same in ATP synthases from all forms of life, yet the protein composition of this domain changed during evolution of the mitochondrial enzyme from a two- to a three-subunit structure (γ, δ, ε). Whereas the mitochondrial γ- and δ-subunits are homologues of the bacterial central stalk proteins, the deliberate addition of subunit ε is poorly understood. Here we report that down-regulation of the gene (ATP15) encoding the ε-subunit rapidly leads to lethal F 0 -mediated proton leaks through the membrane because of the loss of stability of the ATP synthase. The ε-subunit is thus essential for oxidative phosphorylation. Moreover, mutations in F 0 subunits a and c, which slow the proton translocation rate, are identified that prevent ε-deficient ATP synthases from dissipating the electrochemical potential. Cumulatively our data lead us to propose that the ε-subunit evolved to permit operation of the central stalk under the torque imposed at the normal speed of proton movement through mitochondrial F 0 ." @default.
• W2100661426 created "2016-06-24" @default.
• W2100661426 creator A5002815394 @default.
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• W2100661426 date "2014-03-15" @default.
• W2100661426 modified "2023-09-24" @default.
• W2100661426 title "The depletion of F₁subunit ε in yeast leads to an uncoupled respiratory phenotype that is rescued by mutations in the proton-translocating subunits of F₀" @default.
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• W2100661426 doi "https://doi.org/10.1091/mbc.e13-02-0112" @default.
• W2100661426 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3952849" @default.
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• W2100661426 hasPublicationYear "2014" @default.
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