FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100685370> ?p ?o ?g. }

• W2100685370 endingPage "218" @default.
• W2100685370 startingPage "218" @default.
• W2100685370 abstract "Previously, a dominant role of the adaptive immune system in the pathogenesis of Sjögren's syndrome was suspected. Recent advances, however, have revealed a major role of the type I IFN pathway, documented by an increased circulating type I IFN activity and an IFN 'signature' in peripheral blood mononuclear cells and minor salivary gland biopsies from the patients. Polymorphisms in the genes IRF5 and STAT4 leading to increased IFN activation are associated with disease susceptibility. In the pathogenesis of Sjögren's syndrome, the activation of salivary gland epithelial cells appears to be the initial event. Once intrinsically activated, they express costimulatory and Toll-like receptors (TLRs) and MHC class I and II molecules, can present autoantigens and produce proinflammatory cytokines. The subsequent activation of plasmacytoid dendritic cells induces the production of high levels of proinflammatory cytokines in individuals with the risk alleles of the susceptibility genes IRF5 and STAT4. Under the influence of the high IFN concentration in the glands and through TLR ligation, B-cell activating factor is produced by epithelial cells and, together with autoantigen presentation on salivary gland epithelial cells, stimulates the adaptive immune system. In view of the central role of IFNalpha in at least the initiation of the pathogenesis of Sjögren's syndrome, blockade of this cytokine may be a rational therapeutic approach." @default.
• W2100685370 created "2016-06-24" @default.
• W2100685370 creator A5031205195 @default.
• W2100685370 creator A5081541414 @default.
• W2100685370 date "2011-01-01" @default.
• W2100685370 modified "2023-10-08" @default.
• W2100685370 title "Aspects of innate immunity in Sjögren's syndrome" @default.
• W2100685370 cites W1542410645 @default.
• W2100685370 cites W1642457845 @default.
• W2100685370 cites W1670573097 @default.
• W2100685370 cites W1977054607 @default.
• W2100685370 cites W1979816347 @default.
• W2100685370 cites W1980652850 @default.
• W2100685370 cites W1981424925 @default.
• W2100685370 cites W1986628830 @default.
• W2100685370 cites W1997948306 @default.
• W2100685370 cites W2005721240 @default.
• W2100685370 cites W2016447788 @default.
• W2100685370 cites W2025033926 @default.
• W2100685370 cites W2025579203 @default.
• W2100685370 cites W2031580483 @default.
• W2100685370 cites W2031750503 @default.
• W2100685370 cites W2032799815 @default.
• W2100685370 cites W2038051564 @default.
• W2100685370 cites W2043959346 @default.
• W2100685370 cites W2051925328 @default.
• W2100685370 cites W2054270432 @default.
• W2100685370 cites W2062080272 @default.
• W2100685370 cites W2069550453 @default.
• W2100685370 cites W2071830659 @default.
• W2100685370 cites W2072319273 @default.
• W2100685370 cites W2075283457 @default.
• W2100685370 cites W2076690763 @default.
• W2100685370 cites W2080259979 @default.
• W2100685370 cites W2084676421 @default.
• W2100685370 cites W2089647984 @default.
• W2100685370 cites W2136811387 @default.
• W2100685370 cites W2144087336 @default.
• W2100685370 cites W2145736817 @default.
• W2100685370 cites W2145812105 @default.
• W2100685370 cites W2146176590 @default.
• W2100685370 cites W2147086116 @default.
• W2100685370 cites W2148937635 @default.
• W2100685370 cites W2153318159 @default.
• W2100685370 cites W2153729223 @default.
• W2100685370 cites W2162800454 @default.
• W2100685370 cites W2167317609 @default.
• W2100685370 cites W2168781986 @default.
• W2100685370 cites W2168832996 @default.
• W2100685370 cites W2170995600 @default.
• W2100685370 doi "https://doi.org/10.1186/ar3318" @default.
• W2100685370 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3218872" @default.
• W2100685370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21635716" @default.
• W2100685370 hasPublicationYear "2011" @default.
• W2100685370 type Work @default.
• W2100685370 sameAs 2100685370 @default.
• W2100685370 citedByCount "46" @default.
• W2100685370 countsByYear W21006853702013 @default.
• W2100685370 countsByYear W21006853702014 @default.
• W2100685370 countsByYear W21006853702015 @default.
• W2100685370 countsByYear W21006853702016 @default.
• W2100685370 countsByYear W21006853702017 @default.
• W2100685370 countsByYear W21006853702018 @default.
• W2100685370 countsByYear W21006853702019 @default.
• W2100685370 countsByYear W21006853702020 @default.
• W2100685370 countsByYear W21006853702021 @default.
• W2100685370 countsByYear W21006853702022 @default.
• W2100685370 countsByYear W21006853702023 @default.
• W2100685370 crossrefType "journal-article" @default.
• W2100685370 hasAuthorship W2100685370A5031205195 @default.
• W2100685370 hasAuthorship W2100685370A5081541414 @default.
• W2100685370 hasBestOaLocation W21006853701 @default.
• W2100685370 hasConcept C136449434 @default.
• W2100685370 hasConcept C164027704 @default.
• W2100685370 hasConcept C193419808 @default.
• W2100685370 hasConcept C203014093 @default.
• W2100685370 hasConcept C2776914184 @default.
• W2100685370 hasConcept C2778690821 @default.
• W2100685370 hasConcept C2779984610 @default.
• W2100685370 hasConcept C2780942790 @default.
• W2100685370 hasConcept C71924100 @default.
• W2100685370 hasConcept C86803240 @default.
• W2100685370 hasConcept C8891405 @default.
• W2100685370 hasConcept C9173399 @default.
• W2100685370 hasConceptScore W2100685370C136449434 @default.
• W2100685370 hasConceptScore W2100685370C164027704 @default.
• W2100685370 hasConceptScore W2100685370C193419808 @default.
• W2100685370 hasConceptScore W2100685370C203014093 @default.
• W2100685370 hasConceptScore W2100685370C2776914184 @default.
• W2100685370 hasConceptScore W2100685370C2778690821 @default.
• W2100685370 hasConceptScore W2100685370C2779984610 @default.
• W2100685370 hasConceptScore W2100685370C2780942790 @default.
• W2100685370 hasConceptScore W2100685370C71924100 @default.
• W2100685370 hasConceptScore W2100685370C86803240 @default.
• W2100685370 hasConceptScore W2100685370C8891405 @default.
• W2100685370 hasConceptScore W2100685370C9173399 @default.
• W2100685370 hasIssue "3" @default.
• W2100685370 hasLocation W21006853701 @default.

• next