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- W2100687452 abstract "Background. The search continues for a safe, effective, and cheap method for mid-trimester termination of pregnancy. Misoprostol is a strong contender in this respect. The dose schedule of misoprostol is still not fixed. The objective of our present study was to compare the efficacy and adverse events of 2 dose regimens of vaginal misoprostol for second trimester termination. Method. A prospective, randomised, controlled trial was undertaken in 138 women at 14–20 weeks gestation, in a teaching hospital. Subjects were randomised to receive either regime A: 400 µg of intravaginal misoprostol every 3 h, or regime B: loading dose of 600 µg, followed by 200 µg every 3 h. The main outcome measure was the success rate at 48 h, total dose required, induction-abortion interval, and adverse events. Data was analysed by Student's t-test, Mann–Whitney U-test, the chi-squared test or Fisher's exact test, using Statistica 6.0 software. Results. There was no significant difference in the success rates at 24 and 48 h (Regime A: 97.18 and 98.59%; Regime B: 95.45 and 95.45%), and in mean induction-abortion interval (12.97 versus 12.13 h). However, mean misoprostol requirement was significantly higher for Regime A (1701.4 versus 1269.7 µg). The incidence of fever was significantly less in Regime B (32.4 versus 14.9%). Conclusion. Use of vaginal misoprostol for second trimester abortion had comparable efficacy with less drug requirement for the 600 µg loading dose followed by 200 µg 3-hourly regime compared to the 400 µg 3-hourly regime." @default.
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- W2100687452 date "2006-01-01" @default.
- W2100687452 modified "2023-09-23" @default.
- W2100687452 title "Two regimens of vaginal misoprostol in second trimester termination of pregnancy – a prospective randomised trial" @default.
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- W2100687452 doi "https://doi.org/10.1080/00016340601002282" @default.
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