Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100687535> ?p ?o ?g. }
- W2100687535 endingPage "3059" @default.
- W2100687535 startingPage "3039" @default.
- W2100687535 abstract "Significance: Plants produce many small molecules with biomedical potential. Their absorption from foods, metabolism, their effects on physiological and pathological processes, and the mechanisms of action are intensely investigated. Many are known to affect multiple cellular functions. Mitochondria are coming to be recognized as a major target for these compounds, especially redox-active ones, but the mechanisms involved still need clarification. At the same time, frontline research is uncovering the importance of processes involving these organelles for the cell and for an array of physiological and pathological processes. We review the major functions and possible dysfunctions of mitochondria, identify signaling pathways through which plant-derived molecules have an impact, and show how this may be relevant for major pathologies. Recent Advances: Antioxidant, protective effects may arise as a reaction to a low-level pro-oxidant activity, largely taking place at mitochondria. Some plant-derived molecules can activate AMP-dependent kinase, with a consequent upregulation of mitochondrial biogenesis and a potential favorable impact on aging, pathologies like diabetes and neurodegeneration, and on ischemic damage. Critical Issues: The extrapolation of in vitro results and the verification of paradigms in vivo is a key issue for current research on both plant-derived compounds and mitochondria. The low bioavailability of many of these molecules poses a problem for both the study of their activities and their utilization. Future Directions: The further clarification of the role of mitochondria in the activities of plant dietary compounds and their metabolites, mitochondrial targeting, the development of analogs and pro-drugs are all topics for promising research. Antioxid. Redox Signal. 15, 3039–3059." @default.
- W2100687535 created "2016-06-24" @default.
- W2100687535 creator A5001169698 @default.
- W2100687535 creator A5053578537 @default.
- W2100687535 creator A5075678380 @default.
- W2100687535 date "2011-12-01" @default.
- W2100687535 modified "2023-09-23" @default.
- W2100687535 title "Mitochondrial Effects of Plant-Made Compounds" @default.
- W2100687535 cites W101797952 @default.
- W2100687535 cites W1485778651 @default.
- W2100687535 cites W1496434123 @default.
- W2100687535 cites W1509344561 @default.
- W2100687535 cites W1548494899 @default.
- W2100687535 cites W1569565225 @default.
- W2100687535 cites W1573222602 @default.
- W2100687535 cites W1576985941 @default.
- W2100687535 cites W1579296627 @default.
- W2100687535 cites W1602820987 @default.
- W2100687535 cites W1724227103 @default.
- W2100687535 cites W1777548141 @default.
- W2100687535 cites W1778352924 @default.
- W2100687535 cites W1884222370 @default.
- W2100687535 cites W1909184393 @default.
- W2100687535 cites W1920479129 @default.
- W2100687535 cites W1965440944 @default.
- W2100687535 cites W1966191258 @default.
- W2100687535 cites W1966700699 @default.
- W2100687535 cites W1968444524 @default.
- W2100687535 cites W1969156376 @default.
- W2100687535 cites W1969601405 @default.
- W2100687535 cites W1969948260 @default.
- W2100687535 cites W1970276547 @default.
- W2100687535 cites W1970565325 @default.
- W2100687535 cites W1971493688 @default.
- W2100687535 cites W1972544732 @default.
- W2100687535 cites W1972779889 @default.
- W2100687535 cites W1973206036 @default.
- W2100687535 cites W1973281235 @default.
- W2100687535 cites W1973281276 @default.
- W2100687535 cites W1973455163 @default.
- W2100687535 cites W1973476149 @default.
- W2100687535 cites W1974431794 @default.
- W2100687535 cites W1974583613 @default.
- W2100687535 cites W1975143207 @default.
- W2100687535 cites W1975419073 @default.
- W2100687535 cites W1976676780 @default.
- W2100687535 cites W1977178308 @default.
- W2100687535 cites W1977841275 @default.
- W2100687535 cites W1978288476 @default.
- W2100687535 cites W1979496891 @default.
- W2100687535 cites W1979645469 @default.
- W2100687535 cites W1980129665 @default.
- W2100687535 cites W1980631500 @default.
- W2100687535 cites W1981793561 @default.
- W2100687535 cites W1985079080 @default.
- W2100687535 cites W1985730402 @default.
- W2100687535 cites W1986553386 @default.
- W2100687535 cites W1986568749 @default.
- W2100687535 cites W1986810795 @default.
- W2100687535 cites W1988395430 @default.
- W2100687535 cites W1990412352 @default.
- W2100687535 cites W1991960405 @default.
- W2100687535 cites W1993635651 @default.
- W2100687535 cites W1994924724 @default.
- W2100687535 cites W1996315798 @default.
- W2100687535 cites W1996457804 @default.
- W2100687535 cites W1997422422 @default.
- W2100687535 cites W1997671346 @default.
- W2100687535 cites W1998149716 @default.
- W2100687535 cites W1998487027 @default.
- W2100687535 cites W1999218428 @default.
- W2100687535 cites W1999793372 @default.
- W2100687535 cites W2000718634 @default.
- W2100687535 cites W2000732112 @default.
- W2100687535 cites W2001634180 @default.
- W2100687535 cites W2002449811 @default.
- W2100687535 cites W2002907671 @default.
- W2100687535 cites W2003503015 @default.
- W2100687535 cites W2004032478 @default.
- W2100687535 cites W2004112725 @default.
- W2100687535 cites W2004129180 @default.
- W2100687535 cites W2005586848 @default.
- W2100687535 cites W2005953994 @default.
- W2100687535 cites W2006049488 @default.
- W2100687535 cites W2007534790 @default.
- W2100687535 cites W2012309329 @default.
- W2100687535 cites W2015094152 @default.
- W2100687535 cites W2016322897 @default.
- W2100687535 cites W2016804918 @default.
- W2100687535 cites W2016826534 @default.
- W2100687535 cites W2018971639 @default.
- W2100687535 cites W2019560775 @default.
- W2100687535 cites W2019671050 @default.
- W2100687535 cites W2021337133 @default.
- W2100687535 cites W2021612469 @default.
- W2100687535 cites W2022228039 @default.
- W2100687535 cites W2023726011 @default.
- W2100687535 cites W2024825178 @default.