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• W2100691402 endingPage "1641" @default.
• W2100691402 startingPage "1634" @default.
• W2100691402 abstract "Conjugated linoleic acids (CLAs) are conjugated dienoic isomers of linoleic acid. Many people supplement their diets with CLAs to attempt weight loss, and the trans-10,cis-12 isomer (t10,c12-CLA) of CLA reduces adiposity in animal models and humans. However, CLA treatment in mice causes insulin resistance that has been attributed to the lipoatrophic state, which is associated with hyperinsulinemia and hepatic steatosis. Here, we investigated the effect of t10,c12-CLA on adipose tissue inflammation, another factor promoting insulin resistance. We confirmed that t10,c12-CLA daily gavage performed in mice reduces white adipose tissue (WAT) mass and adiponectin and leptin serum levels and provokes hyperinsulinemia. In parallel, we demonstrated that this CLA isomer led to a rapid induction of inflammatory factors such as tumor necrosis factor-alpha and interleukin-6 gene expression in WAT without affecting their serum levels. In vitro, t10,c12-CLA directly induced IL-6 secretion in 3T3-L1 adipocytes by an nuclear factor-kappaB-dependent mechanism. In vivo, however, the lipoatrophic adipose tissue of CLA-treated mice was notable for a dramatic increase in macrophage infiltration and gene expression. Thus, CLA supplementation directly induces inflammatory gene expression in adipocytes and also promotes macrophage infiltration into adipose tissue to a local inflammatory state that contributes to insulin resistance." @default.
• W2100691402 created "2016-06-24" @default.
• W2100691402 creator A5006781982 @default.
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• W2100691402 creator A5068046166 @default.
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• W2100691402 date "2006-06-01" @default.
• W2100691402 modified "2023-10-14" @default.
• W2100691402 title "Nutritional Supplementation With<i>trans</i>-10,<i>cis</i>-12–Conjugated Linoleic Acid Induces Inflammation of White Adipose Tissue" @default.
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• W2100691402 doi "https://doi.org/10.2337/db06-0036" @default.
• W2100691402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16731825" @default.
• W2100691402 hasPublicationYear "2006" @default.
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