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- W2100693719 abstract "There is substantial evidence based on well designed epidemiologic studies for low cancer rates in patients with Parkinson disease (PD). This risk reduction cannot be attributed to the recognized low life-long incidence of smoking in patients with PD, as not only smoking-related cancers but also non-smoking-related ones are less common in PD. Whereas the risk for most cancers appears to be relatively low in patients with PD, breast cancer and melanomas occur more frequently in the PD population as compared with controls. The relationship between this peculiar pattern of cancer rates and PD might be related to the involvement of common genes in both diseases. Mutations in <i>parkin</i> gene, for example, have been reported in several types of cancer. Furthermore, genes involved in familial forms of PD appear to be abnormally expressed in cancers. Thus, <i>parkin</i> and <i>PINK1</i> might be tumor suppressor genes, whereas <i>DJ-1</i> is an oncogene. Cell survival signals may differ owing to mutated genes and represent two opposite extremes such as cell proliferation in cancer and cell death due to apoptosis in PD. Unraveling the link between PD and cancer may open a therapeutic window for both diseases." @default.
- W2100693719 created "2016-06-24" @default.
- W2100693719 creator A5050747712 @default.
- W2100693719 creator A5068655451 @default.
- W2100693719 date "2007-08-15" @default.
- W2100693719 modified "2023-10-03" @default.
- W2100693719 title "Are Parkinson disease patients protected from some but not all cancers?" @default.
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- W2100693719 doi "https://doi.org/10.1212/01.wnl.0000277638.63767.b8" @default.
- W2100693719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19001259" @default.
- W2100693719 hasPublicationYear "2007" @default.
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