Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100694005> ?p ?o ?g. }
- W2100694005 endingPage "338" @default.
- W2100694005 startingPage "311" @default.
- W2100694005 abstract "Interstitial cells of Cajal (ICC) are the pacemakers in gastrointestinal (GI) muscles, and these cells also mediate or transduce inputs from the enteric nervous system. Different classes of ICC are involved in pacemaking and neurotransmission. ICC express specific ionic conductances that make them unique in their ability to generate and propagate slow waves in GI muscles or transduce neural inputs. Much of what we know about the function of ICC comes from developmental studies that were made possible by the discoveries that ICC express c-kit and proper development of ICC depends upon signalling via the Kit receptor pathway. Manipulating Kit signalling with reagents to block the receptor or downstream signalling pathways or by using mutant mice in which Kit or its ligand, stem cell factor, are defective has allowed novel studies into the specific functions of the different classes of ICC in several regions of the GI tract. Kit is also a surface antigen that can be used to conveniently label ICC in GI muscles. Immunohistochemical studies using Kit antibodies have expanded our knowledge about the ICC phenotype, the structure of ICC networks, the interactions of ICC with other cells in the gut wall, and the loss of ICC in some clinical disorders. Preparations made devoid of ICC have also allowed analysis of the consequences of losing specific classes of ICC on GI motility. This review describes recent advances in our knowledge about the development and plasticity of ICC and how developmental studies have contributed to our understanding of the functions of ICC. We have reviewed the clinical literature and discussed how loss or defects in ICC affect GI motor function." @default.
- W2100694005 created "2016-06-24" @default.
- W2100694005 creator A5028080442 @default.
- W2100694005 creator A5031123252 @default.
- W2100694005 creator A5037646851 @default.
- W2100694005 creator A5055296224 @default.
- W2100694005 creator A5067578519 @default.
- W2100694005 date "1999-10-01" @default.
- W2100694005 modified "2023-10-14" @default.
- W2100694005 title "Development and plasticity of interstitial cells of Cajal" @default.
- W2100694005 cites W1484947470 @default.
- W2100694005 cites W1512958442 @default.
- W2100694005 cites W154745092 @default.
- W2100694005 cites W1581232786 @default.
- W2100694005 cites W1752312133 @default.
- W2100694005 cites W1794896472 @default.
- W2100694005 cites W1864063551 @default.
- W2100694005 cites W1872667540 @default.
- W2100694005 cites W1899026035 @default.
- W2100694005 cites W1963657027 @default.
- W2100694005 cites W1966378772 @default.
- W2100694005 cites W1966585431 @default.
- W2100694005 cites W1967167619 @default.
- W2100694005 cites W1968102170 @default.
- W2100694005 cites W1970011482 @default.
- W2100694005 cites W1975984185 @default.
- W2100694005 cites W1976331831 @default.
- W2100694005 cites W1977674787 @default.
- W2100694005 cites W1980730770 @default.
- W2100694005 cites W1981811756 @default.
- W2100694005 cites W1986243430 @default.
- W2100694005 cites W1988530903 @default.
- W2100694005 cites W1990872870 @default.
- W2100694005 cites W1991175004 @default.
- W2100694005 cites W1994553636 @default.
- W2100694005 cites W1996310829 @default.
- W2100694005 cites W1996437147 @default.
- W2100694005 cites W1996590476 @default.
- W2100694005 cites W1997523354 @default.
- W2100694005 cites W1997557173 @default.
- W2100694005 cites W1998675901 @default.
- W2100694005 cites W2000875765 @default.
- W2100694005 cites W2002223231 @default.
- W2100694005 cites W2002582003 @default.
- W2100694005 cites W2003310565 @default.
- W2100694005 cites W2004686233 @default.
- W2100694005 cites W2006506079 @default.
- W2100694005 cites W2007206244 @default.
- W2100694005 cites W2012636146 @default.
- W2100694005 cites W2017708435 @default.
- W2100694005 cites W2018293558 @default.
- W2100694005 cites W2018921761 @default.
- W2100694005 cites W2020256228 @default.
- W2100694005 cites W2021273608 @default.
- W2100694005 cites W2023777293 @default.
- W2100694005 cites W2024324283 @default.
- W2100694005 cites W2025590033 @default.
- W2100694005 cites W2027636000 @default.
- W2100694005 cites W2027666380 @default.
- W2100694005 cites W2029547669 @default.
- W2100694005 cites W2031111947 @default.
- W2100694005 cites W2031237579 @default.
- W2100694005 cites W2033976196 @default.
- W2100694005 cites W2035357722 @default.
- W2100694005 cites W2037010084 @default.
- W2100694005 cites W2037256203 @default.
- W2100694005 cites W2037695813 @default.
- W2100694005 cites W2039046119 @default.
- W2100694005 cites W2048142140 @default.
- W2100694005 cites W2053419204 @default.
- W2100694005 cites W2053745722 @default.
- W2100694005 cites W2056614650 @default.
- W2100694005 cites W2059853821 @default.
- W2100694005 cites W2061150131 @default.
- W2100694005 cites W2063436204 @default.
- W2100694005 cites W2066731081 @default.
- W2100694005 cites W2067405166 @default.
- W2100694005 cites W2070557583 @default.
- W2100694005 cites W2074347208 @default.
- W2100694005 cites W2077289542 @default.
- W2100694005 cites W2077716740 @default.
- W2100694005 cites W2078812681 @default.
- W2100694005 cites W2082001881 @default.
- W2100694005 cites W2082886818 @default.
- W2100694005 cites W2083768027 @default.
- W2100694005 cites W2086774260 @default.
- W2100694005 cites W2088444907 @default.
- W2100694005 cites W2088466043 @default.
- W2100694005 cites W2089369945 @default.
- W2100694005 cites W2092514582 @default.
- W2100694005 cites W2093268674 @default.
- W2100694005 cites W2103774582 @default.
- W2100694005 cites W2107894734 @default.
- W2100694005 cites W2110463788 @default.
- W2100694005 cites W2112811492 @default.
- W2100694005 cites W2119902383 @default.
- W2100694005 cites W2128738543 @default.
- W2100694005 cites W2129904462 @default.