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• W2100694433 endingPage "55" @default.
• W2100694433 startingPage "55" @default.
• W2100694433 abstract "<h3>Objectives</h3> To delineate the magnitude of susceptibility to age-related macular degeneration (AMD) due to common variants in the gene for complement factor H (<i>CFH</i>) and the predicted gene<i>LOC387715</i>and to determine whether these variants interact with modifiable risk factors. <h3>Methods</h3> We compared cases who developed AMD (n = 457) with 1071 age- and sex-matched control subjects in a prospective nested case-control study within the Nurses' Health Study and the Health Professionals Follow-up Study. We determined the incidence rate ratios and 95% confidence intervals (CIs) for AMD for each genotype and examined the interactions with modifiable risk factors. <h3>Results</h3> Participants with 1 or 2 copies of the Y402H variant of<i>CFH</i>were, respectively, 1.98 (95% CI, 1.64-2.40) and 3.92 (95% CI, 2.69-5.76) times more likely to develop AMD, whereas the incident rate ratios (95% CIs) for 1 and 2 copies of<i>LOC387715</i>A69S were 2.38 (1.92-2.96) and 5.66 (3.69-8.76), respectively. The fraction of AMD cases attributable to these 2 variants was 63% (95% CI, 58%-68%). Subjects homozygous for both risk alleles had a 50-fold increased risk of AMD (95% CI, 10.8-237), and cigarette smoking and obesity multiplied the risks associated with these variants. <h3>Conclusion</h3> Age-related macular degeneration has emerged as a paradigmatic example of a common disease caused by the interplay of genetic predisposition and exposure to modifiable risk factors." @default.
• W2100694433 created "2016-06-24" @default.
• W2100694433 creator A5054111608 @default.
• W2100694433 date "2007-01-01" @default.
• W2100694433 modified "2023-09-25" @default.
• W2100694433 title "A Prospective Study of 2 Major Age-Related Macular Degeneration Susceptibility Alleles and Interactions With Modifiable Risk Factors" @default.
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• W2100694433 doi "https://doi.org/10.1001/archopht.125.1.55" @default.
• W2100694433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17210852" @default.
• W2100694433 hasPublicationYear "2007" @default.
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