FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100695475> ?p ?o ?g. }

• W2100695475 endingPage "150" @default.
• W2100695475 startingPage "139" @default.
• W2100695475 abstract "The present study evaluated high-speed chronoamperometry as a method for measuring the clearance of serotonin (5-HT) from extracellular space in vivo. Male Sprague-Dawley rats were anaesthetized and a Nafion-coated, carbon fiber electrode, attached to a multibarrel pipette, was lowered into the subgranular layer of the dentate gyrus, a region which receives dense serotonergic innervation, or the corpus callosum, a fiber tract relatively devoid of the 5-HT transporter (SERT). Serotonin, pressure ejected into these regions, produced replicable electrochemical signals. The amplitude and time course of the signals were significantly prolonged in the corpus callosum compared to the dentate gyrus. Similarly, signals produced by locally applied 5-HT in the dentate gyrus of rats following destruction of hippocampal serotonergic innervation with 5,7-dihydroxytryptamine (5,7-DHT), were significantly enhanced compared to those observed in control animals. The time course of the 5-HT signal was significantly prolonged by local application of the selective 5-HT reuptake inhibitor, fluvoxamine, into the dentate gyrus. By contrast, fluvoxamine did not modify the clearance of 5-HT when locally applied into the dentate gyrus of 5,7-DHT lesioned rats or into the corpus callosum of intact rats. Taken together, these data demonstrate that in intact rats, the SERT contributes to the clearance of exogenously applied 5-HT from the extracellular space. Under the experimental conditions used in this study, high-speed chronoamperometry proved to be a reliable method for directly measuring extracellular 5-HT and appears to be a valuable tool for the study of 5-HT clearance by the SERT in vivo." @default.
• W2100695475 created "2016-06-24" @default.
• W2100695475 creator A5024517119 @default.
• W2100695475 creator A5037708891 @default.
• W2100695475 creator A5058527875 @default.
• W2100695475 creator A5070676831 @default.
• W2100695475 creator A5084834625 @default.
• W2100695475 date "1997-12-01" @default.
• W2100695475 modified "2023-10-13" @default.
• W2100695475 title "In vivo chronoamperometric measurements of the clearance of exogenously applied serotonin in the rat dentate gyrus" @default.
• W2100695475 cites W1642639203 @default.
• W2100695475 cites W1860114987 @default.
• W2100695475 cites W1865166881 @default.
• W2100695475 cites W1965681548 @default.
• W2100695475 cites W1973178390 @default.
• W2100695475 cites W1981008737 @default.
• W2100695475 cites W1985803034 @default.
• W2100695475 cites W1987097394 @default.
• W2100695475 cites W1989796420 @default.
• W2100695475 cites W1989901803 @default.
• W2100695475 cites W1990567511 @default.
• W2100695475 cites W1995283839 @default.
• W2100695475 cites W2000519887 @default.
• W2100695475 cites W2001942123 @default.
• W2100695475 cites W2008700794 @default.
• W2100695475 cites W2010249532 @default.
• W2100695475 cites W2010306385 @default.
• W2100695475 cites W2014855692 @default.
• W2100695475 cites W2017031786 @default.
• W2100695475 cites W2023676685 @default.
• W2100695475 cites W2029499739 @default.
• W2100695475 cites W2029748309 @default.
• W2100695475 cites W2036939881 @default.
• W2100695475 cites W2040798945 @default.
• W2100695475 cites W2041378773 @default.
• W2100695475 cites W2044773067 @default.
• W2100695475 cites W2047687380 @default.
• W2100695475 cites W2050276270 @default.
• W2100695475 cites W2051531767 @default.
• W2100695475 cites W2053481547 @default.
• W2100695475 cites W2058856551 @default.
• W2100695475 cites W2064332460 @default.
• W2100695475 cites W2066497793 @default.
• W2100695475 cites W2066562577 @default.
• W2100695475 cites W2070619325 @default.
• W2100695475 cites W2075248372 @default.
• W2100695475 cites W2086151698 @default.
• W2100695475 cites W2091153095 @default.
• W2100695475 cites W2092449291 @default.
• W2100695475 cites W2099703466 @default.
• W2100695475 cites W2130939305 @default.
• W2100695475 cites W2153274306 @default.
• W2100695475 doi "https://doi.org/10.1016/s0165-0270(97)00144-1" @default.
• W2100695475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9497010" @default.
• W2100695475 hasPublicationYear "1997" @default.
• W2100695475 type Work @default.
• W2100695475 sameAs 2100695475 @default.
• W2100695475 citedByCount "38" @default.
• W2100695475 countsByYear W21006954752012 @default.
• W2100695475 countsByYear W21006954752016 @default.
• W2100695475 countsByYear W21006954752018 @default.
• W2100695475 countsByYear W21006954752020 @default.
• W2100695475 countsByYear W21006954752021 @default.
• W2100695475 crossrefType "journal-article" @default.
• W2100695475 hasAuthorship W2100695475A5024517119 @default.
• W2100695475 hasAuthorship W2100695475A5037708891 @default.
• W2100695475 hasAuthorship W2100695475A5058527875 @default.
• W2100695475 hasAuthorship W2100695475A5070676831 @default.
• W2100695475 hasAuthorship W2100695475A5084834625 @default.
• W2100695475 hasConcept C126322002 @default.
• W2100695475 hasConcept C134018914 @default.
• W2100695475 hasConcept C147789679 @default.
• W2100695475 hasConcept C148762608 @default.
• W2100695475 hasConcept C169760540 @default.
• W2100695475 hasConcept C170493617 @default.
• W2100695475 hasConcept C17525397 @default.
• W2100695475 hasConcept C185592680 @default.
• W2100695475 hasConcept C201750760 @default.
• W2100695475 hasConcept C2775864247 @default.
• W2100695475 hasConcept C2776134451 @default.
• W2100695475 hasConcept C2776464000 @default.
• W2100695475 hasConcept C2777542384 @default.
• W2100695475 hasConcept C2777869211 @default.
• W2100695475 hasConcept C2778141235 @default.
• W2100695475 hasConcept C2778499278 @default.
• W2100695475 hasConcept C2779910183 @default.
• W2100695475 hasConcept C2781176699 @default.
• W2100695475 hasConcept C28328180 @default.
• W2100695475 hasConcept C37000724 @default.
• W2100695475 hasConcept C52859227 @default.
• W2100695475 hasConcept C71924100 @default.
• W2100695475 hasConcept C86803240 @default.
• W2100695475 hasConcept C95444343 @default.
• W2100695475 hasConceptScore W2100695475C126322002 @default.
• W2100695475 hasConceptScore W2100695475C134018914 @default.
• W2100695475 hasConceptScore W2100695475C147789679 @default.
• W2100695475 hasConceptScore W2100695475C148762608 @default.
• W2100695475 hasConceptScore W2100695475C169760540 @default.

• next