FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100698859> ?p ?o ?g. }

• W2100698859 endingPage "528" @default.
• W2100698859 startingPage "523" @default.
• W2100698859 abstract "Thyrotropin (TSH) receptor (TSHr) mutations have been investigated in relation to Graves' disease (GD) genetic susceptibility under the hypothesis that a modified antigen may have novel immunogenic properties. The prevalence of three germline polymorphisms - D36H, P52T, and D727E - were studied in a cohort of multiracial GD patients together with their associations with disease state, Graves' ophthalmopathy, and thyroid autoantibodies titers. Polymerase chain reaction products of exon 1 and 10e of the TSHr were generated from 164 GD patients (109 Chinese, 34 Malays, and 21 Indians) and 240 individuals with no thyroid illnesses (74 Chinese, 84 Malays, and 82 Indians). Mutations were detected by single-strand conformational polymorphism and confirmed with direct sequencing. The D36H mutation was absent, while significant ethnic differences in the distribution of the P52T and D727E mutations were found. The levels of thyroid autoantibodies also differed significantly amongst the three ethnic groups, with the Indian cohort having the lowest titer. Both the P52T and D727E mutations were not associated with GD. An intron mutation, C/G+63IVS1, was detected and showed significant association with GD. Overall, it conferred a twofold increase risk of GD, while subgroup analysis showed increased odds ratios of 2.4 for Chinese (p = 0.008) and 2.8 for Indian (p = 0.049) but not for the Malay ethnic group. Together with recent identification of disease susceptibility markers in the region of the TSHr gene, these results are supportive of genetic factors existing in this region that may be in linkage disequilibrium with the inheritance of various TSHr polymorphisms." @default.
• W2100698859 created "2016-06-24" @default.
• W2100698859 creator A5033161620 @default.
• W2100698859 creator A5046426427 @default.
• W2100698859 creator A5073214010 @default.
• W2100698859 date "2003-06-01" @default.
• W2100698859 modified "2023-10-18" @default.
• W2100698859 title "Association of Graves' Disease with Intragenic Polymorphism of the Thyrotropin Receptor Gene in a Cohort of Singapore Patients of Multi-Ethnic Origins" @default.
• W2100698859 cites W1966926094 @default.
• W2100698859 cites W1978510166 @default.
• W2100698859 cites W1978663857 @default.
• W2100698859 cites W1982417431 @default.
• W2100698859 cites W1987132574 @default.
• W2100698859 cites W1994679265 @default.
• W2100698859 cites W2019709402 @default.
• W2100698859 cites W2022066514 @default.
• W2100698859 cites W2024768574 @default.
• W2100698859 cites W2025601250 @default.
• W2100698859 cites W2033248235 @default.
• W2100698859 cites W2034191939 @default.
• W2100698859 cites W2046746736 @default.
• W2100698859 cites W2049956108 @default.
• W2100698859 cites W2056019876 @default.
• W2100698859 cites W2057566642 @default.
• W2100698859 cites W2069105141 @default.
• W2100698859 cites W2074034912 @default.
• W2100698859 cites W2074870155 @default.
• W2100698859 cites W2082853752 @default.
• W2100698859 cites W2084523008 @default.
• W2100698859 cites W2106507718 @default.
• W2100698859 cites W2149363036 @default.
• W2100698859 cites W2163222002 @default.
• W2100698859 cites W2249261929 @default.
• W2100698859 cites W2337145959 @default.
• W2100698859 cites W4234480585 @default.
• W2100698859 cites W4236539196 @default.
• W2100698859 cites W4237783967 @default.
• W2100698859 cites W4243522176 @default.
• W2100698859 cites W4251372587 @default.
• W2100698859 cites W4255552292 @default.
• W2100698859 cites W4256729998 @default.
• W2100698859 doi "https://doi.org/10.1089/105072503322238773" @default.
• W2100698859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12930595" @default.
• W2100698859 hasPublicationYear "2003" @default.
• W2100698859 type Work @default.
• W2100698859 sameAs 2100698859 @default.
• W2100698859 citedByCount "50" @default.
• W2100698859 countsByYear W21006988592012 @default.
• W2100698859 countsByYear W21006988592013 @default.
• W2100698859 countsByYear W21006988592014 @default.
• W2100698859 countsByYear W21006988592015 @default.
• W2100698859 countsByYear W21006988592016 @default.
• W2100698859 countsByYear W21006988592017 @default.
• W2100698859 countsByYear W21006988592019 @default.
• W2100698859 countsByYear W21006988592020 @default.
• W2100698859 countsByYear W21006988592022 @default.
• W2100698859 countsByYear W21006988592023 @default.
• W2100698859 crossrefType "journal-article" @default.
• W2100698859 hasAuthorship W2100698859A5033161620 @default.
• W2100698859 hasAuthorship W2100698859A5046426427 @default.
• W2100698859 hasAuthorship W2100698859A5073214010 @default.
• W2100698859 hasConcept C104317684 @default.
• W2100698859 hasConcept C126322002 @default.
• W2100698859 hasConcept C134018914 @default.
• W2100698859 hasConcept C135763542 @default.
• W2100698859 hasConcept C156957248 @default.
• W2100698859 hasConcept C159654299 @default.
• W2100698859 hasConcept C163764329 @default.
• W2100698859 hasConcept C180754005 @default.
• W2100698859 hasConcept C197754878 @default.
• W2100698859 hasConcept C203014093 @default.
• W2100698859 hasConcept C2776652619 @default.
• W2100698859 hasConcept C2777608072 @default.
• W2100698859 hasConcept C35605836 @default.
• W2100698859 hasConcept C526584372 @default.
• W2100698859 hasConcept C54355233 @default.
• W2100698859 hasConcept C71924100 @default.
• W2100698859 hasConcept C72563966 @default.
• W2100698859 hasConcept C86803240 @default.
• W2100698859 hasConcept C90924648 @default.
• W2100698859 hasConceptScore W2100698859C104317684 @default.
• W2100698859 hasConceptScore W2100698859C126322002 @default.
• W2100698859 hasConceptScore W2100698859C134018914 @default.
• W2100698859 hasConceptScore W2100698859C135763542 @default.
• W2100698859 hasConceptScore W2100698859C156957248 @default.
• W2100698859 hasConceptScore W2100698859C159654299 @default.
• W2100698859 hasConceptScore W2100698859C163764329 @default.
• W2100698859 hasConceptScore W2100698859C180754005 @default.
• W2100698859 hasConceptScore W2100698859C197754878 @default.
• W2100698859 hasConceptScore W2100698859C203014093 @default.
• W2100698859 hasConceptScore W2100698859C2776652619 @default.
• W2100698859 hasConceptScore W2100698859C2777608072 @default.
• W2100698859 hasConceptScore W2100698859C35605836 @default.
• W2100698859 hasConceptScore W2100698859C526584372 @default.
• W2100698859 hasConceptScore W2100698859C54355233 @default.
• W2100698859 hasConceptScore W2100698859C71924100 @default.
• W2100698859 hasConceptScore W2100698859C72563966 @default.
• W2100698859 hasConceptScore W2100698859C86803240 @default.

• next