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• W2100706488 abstract "Antibodies against nuclear self-antigens are characteristic of systemic autoimmunity, although mechanisms promoting their generation and selection are unclear. Here, we report that B cells containing the Y-linked autoimmune accelerator (Yaa) locus are intrinsically biased toward nucleolar antigens because of increased expression of TLR7, a single-stranded RNA-binding innate immune receptor. The TLR7 gene is duplicated in Yaa mice because of a 4-Megabase expansion of the pseudoautosomal region. These results reveal high divergence in mouse Y chromosomes and represent a good example of gene copy number qualitatively altering a polygenic disease manifestation." @default.
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• W2100706488 date "2006-06-16" @default.
• W2100706488 modified "2023-10-06" @default.
• W2100706488 title "Autoreactive B Cell Responses to RNA-Related Antigens Due to <i>TLR7</i> Gene Duplication" @default.
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• W2100706488 doi "https://doi.org/10.1126/science.1124978" @default.
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