FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100709210> ?p ?o ?g. }

• W2100709210 endingPage "4852" @default.
• W2100709210 startingPage "4841" @default.
• W2100709210 abstract "The SWI3-related gene product (SRG3), a component of the mouse SWI/SNF complex, has been suggested to have an alternative function. Here, we demonstrate that in the prostate transactivation of the androgen receptor (AR) is modulated by SRG3 in multiple ways. The expression of SRG3, which is developmentally regulated in the prostate, is induced by androgen through AR. SRG3 in turn enhances the transactivation of AR, providing a positive feedback regulatory loop. The SRG3 coactivation of AR transactivation is achieved through the recruitment of coactivator SRC-1, the protein level of which is upregulated by SRG3, providing another pathway of positive regulation. Interestingly, SRG3 coactivation of AR transactivation is fully functional in BRG1/BRM-deficient C33A cells and the AR/SRG3/SRC-1 complex formed in vivo contains neither BRG1 nor BRM protein, suggesting the possibility of an SRG3 function independent of the SWI/SNF complex. Importantly, the AR/SRG3/SRC-1 complex occupies androgen response elements on the endogenous SRG3 and PSA promoter in an androgen-dependent manner in mouse prostate and LNCaP cells, respectively, inducing gene expression. These results suggest that the multiple positive regulatory mechanisms of AR transactivation by SRG3 may be important for the rapid proliferation of prostate cells during prostate development and regeneration." @default.
• W2100709210 created "2016-06-24" @default.
• W2100709210 creator A5008122524 @default.
• W2100709210 creator A5008186315 @default.
• W2100709210 creator A5018013764 @default.
• W2100709210 creator A5030594637 @default.
• W2100709210 creator A5041552153 @default.
• W2100709210 creator A5051338980 @default.
• W2100709210 creator A5060664681 @default.
• W2100709210 creator A5074990799 @default.
• W2100709210 creator A5091660214 @default.
• W2100709210 date "2005-06-01" @default.
• W2100709210 modified "2023-09-23" @default.
• W2100709210 title "Modulation of Androgen Receptor Transactivation by the SWI3-Related Gene Product (SRG3) in Multiple Ways" @default.
• W2100709210 cites W140697957 @default.
• W2100709210 cites W1504034854 @default.
• W2100709210 cites W1544169104 @default.
• W2100709210 cites W1608648269 @default.
• W2100709210 cites W1674624604 @default.
• W2100709210 cites W1863364305 @default.
• W2100709210 cites W1963677817 @default.
• W2100709210 cites W1969279502 @default.
• W2100709210 cites W1974220331 @default.
• W2100709210 cites W1976903076 @default.
• W2100709210 cites W1985063313 @default.
• W2100709210 cites W1988411134 @default.
• W2100709210 cites W1989183186 @default.
• W2100709210 cites W1990781244 @default.
• W2100709210 cites W2004988279 @default.
• W2100709210 cites W2009726317 @default.
• W2100709210 cites W2022237004 @default.
• W2100709210 cites W2026237709 @default.
• W2100709210 cites W2030571655 @default.
• W2100709210 cites W2031432484 @default.
• W2100709210 cites W2033281378 @default.
• W2100709210 cites W2042164259 @default.
• W2100709210 cites W2054188881 @default.
• W2100709210 cites W2057894015 @default.
• W2100709210 cites W2068733538 @default.
• W2100709210 cites W2074974586 @default.
• W2100709210 cites W2077907808 @default.
• W2100709210 cites W2079196098 @default.
• W2100709210 cites W2084371773 @default.
• W2100709210 cites W2093379565 @default.
• W2100709210 cites W2094838095 @default.
• W2100709210 cites W2095907411 @default.
• W2100709210 cites W2095911393 @default.
• W2100709210 cites W2098031862 @default.
• W2100709210 cites W2102386167 @default.
• W2100709210 cites W2110250638 @default.
• W2100709210 cites W2123367926 @default.
• W2100709210 cites W2125069527 @default.
• W2100709210 cites W2125407920 @default.
• W2100709210 cites W2128840922 @default.
• W2100709210 cites W2137658990 @default.
• W2100709210 cites W2142494230 @default.
• W2100709210 cites W2146689455 @default.
• W2100709210 cites W2151386071 @default.
• W2100709210 cites W2155739693 @default.
• W2100709210 cites W2157530175 @default.
• W2100709210 cites W2159921182 @default.
• W2100709210 cites W2160982258 @default.
• W2100709210 cites W2161506097 @default.
• W2100709210 cites W2164472870 @default.
• W2100709210 cites W2340200299 @default.
• W2100709210 cites W2411276724 @default.
• W2100709210 cites W4241870034 @default.
• W2100709210 cites W88342265 @default.
• W2100709210 doi "https://doi.org/10.1128/mcb.25.12.4841-4852.2005" @default.
• W2100709210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1140583" @default.
• W2100709210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15923603" @default.
• W2100709210 hasPublicationYear "2005" @default.
• W2100709210 type Work @default.
• W2100709210 sameAs 2100709210 @default.
• W2100709210 citedByCount "27" @default.
• W2100709210 countsByYear W21007092102012 @default.
• W2100709210 countsByYear W21007092102015 @default.
• W2100709210 countsByYear W21007092102017 @default.
• W2100709210 countsByYear W21007092102020 @default.
• W2100709210 countsByYear W21007092102021 @default.
• W2100709210 countsByYear W21007092102022 @default.
• W2100709210 countsByYear W21007092102023 @default.
• W2100709210 crossrefType "journal-article" @default.
• W2100709210 hasAuthorship W2100709210A5008122524 @default.
• W2100709210 hasAuthorship W2100709210A5008186315 @default.
• W2100709210 hasAuthorship W2100709210A5018013764 @default.
• W2100709210 hasAuthorship W2100709210A5030594637 @default.
• W2100709210 hasAuthorship W2100709210A5041552153 @default.
• W2100709210 hasAuthorship W2100709210A5051338980 @default.
• W2100709210 hasAuthorship W2100709210A5060664681 @default.
• W2100709210 hasAuthorship W2100709210A5074990799 @default.
• W2100709210 hasAuthorship W2100709210A5091660214 @default.
• W2100709210 hasBestOaLocation W21007092102 @default.
• W2100709210 hasConcept C104317684 @default.
• W2100709210 hasConcept C121608353 @default.
• W2100709210 hasConcept C1292079 @default.
• W2100709210 hasConcept C134018914 @default.
• W2100709210 hasConcept C150194340 @default.

• next