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- W2100712992 abstract "P-glycoprotein accounts for the most intrinsic and acquired cancer multidrug resistance. To inhibit the expression of P-glycoprotein is one of the effective ways to reverse cancer drug resistance. Honokiol, a naturally occurring compound, has been demonstrated to combat cancer through mechanisms including inhibition of angiogenesis and induction of apoptosis. Here, we show that honokiol down-regulated the expression of P-glycoprotein at mRNA and protein levels in MCF-7/ADR, a human breast MDR cancer cell line. The down-regulation of P-glycoprotein was accompanied with a partial recovery of the intracellular drug accumulation, and of the sensitivities toward adriamycin. This study reveals a novel function of honokiol as an anti-cancer agent." @default.
- W2100712992 created "2016-06-24" @default.
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- W2100712992 date "2006-11-01" @default.
- W2100712992 modified "2023-10-11" @default.
- W2100712992 title "Down-regulation of P-glycoprotein expression in MDR breast cancer cell MCF-7/ADR by honokiol" @default.
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- W2100712992 doi "https://doi.org/10.1016/j.canlet.2005.11.031" @default.
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