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- W2100714842 abstract "Summary: The mammalian target of rapamycin (mTOR) is an intracellular kinase that regulates cell growth and metabolism. Its specific inhibitor rapamycin is currently used in transplant recipients as an immunosuppressive drug to prevent allograft rejection. Studies have shown complex and diverse mechanisms for the immunosuppressive effects of rapamycin. The drug has been reported to inhibit T-cell proliferation, induce anergy, modulate T-cell trafficking, promote regulatory T cells, and also prevent maturation of dendritic cells as well as production of type I interferon. However, several other studies have paradoxically demonstrated immunostimulatory effects of rapamycin by improving antigen presentation and regulating cytokine production from macrophages and myeloid dendritic cells. Recently, it has been shown that rapamycin also exhibits immunostimulatory effects on memory CD8+ T-cell differentiation. The drug improved both quantity and quality of memory CD8+ T cells induced by viral infection and vaccination, showing that mTOR is a major regulator of memory CD8+ T-cell differentiation. These discoveries have implications for the development of novel vaccine regimens. Here, we review the role of mTOR in memory CD8+ T-cell differentiation and compare the effect of rapamycin among CD8+ T cells, CD4+ T cells, and dendritic cells. Also, we discuss potential application of these findings in a clinical setting." @default.
- W2100714842 created "2016-06-24" @default.
- W2100714842 creator A5016808814 @default.
- W2100714842 creator A5038996345 @default.
- W2100714842 creator A5054876564 @default.
- W2100714842 date "2010-04-28" @default.
- W2100714842 modified "2023-10-16" @default.
- W2100714842 title "The role of mTOR in memory CD8+ T-cell differentiation" @default.
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- W2100714842 doi "https://doi.org/10.1111/j.0105-2896.2010.00898.x" @default.
- W2100714842 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3760155" @default.
- W2100714842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20536567" @default.
- W2100714842 hasPublicationYear "2010" @default.
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