Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100730818> ?p ?o ?g. }
- W2100730818 endingPage "1046" @default.
- W2100730818 startingPage "1034" @default.
- W2100730818 abstract "Studies have shown that antifibrinolytic (aprotinin, tranexamic acid, epsilon-aminocaproic acid) reduce blood loss in orthopedic surgery. However, most lacked sufficient power to evaluate the efficacy and safety on clinical outcomes. This meta-analysis aims to evaluate whether intravenous antifibrinolytics, when compared with placebo, reduce perioperative allogeneic erythrocyte transfusion requirement in adults undergoing orthopedic surgery and whether it might increase the risk of venous thromboembolism. From MEDLINE, EMBASE, and the Cochrane Controlled Trials Register, the authors identified 43 randomized controlled trials in total hip and knee arthroplasty, spine fusion, musculoskeletal sepsis, or tumor surgery performed to July 2005 (for aprotinin, 23 trials with 1,268 participants; tranexamic acid, 20 with 1,084; epsilon-aminocaproic acid, 4 with 171). Aprotinin and tranexamic acid reduced significantly the proportion of patients requiring allogeneic erythrocyte transfusion according to a transfusion protocol. The odds ratio was 0.43 (95% confidence interval, 0.28-0.64) for aprotinin and 0.17 (0.11-0.24) for tranexamic acid. Results suggest a dose-effect relation with tranexamic acid. Epsilon-aminocaproic acid was not efficacious. Unfortunately, data were too limited for any conclusions regarding safety. Although the results suggest that aprotinin and tranexamic acid significantly reduce allogeneic erythrocyte transfusion, further evaluation of safety is required before recommending the use of antifibrinolytics in orthopedic surgery." @default.
- W2100730818 created "2016-06-24" @default.
- W2100730818 creator A5012237755 @default.
- W2100730818 creator A5017392501 @default.
- W2100730818 creator A5020949450 @default.
- W2100730818 creator A5030686807 @default.
- W2100730818 creator A5046888718 @default.
- W2100730818 creator A5063724683 @default.
- W2100730818 creator A5075900146 @default.
- W2100730818 creator A5086036714 @default.
- W2100730818 date "2006-11-01" @default.
- W2100730818 modified "2023-10-18" @default.
- W2100730818 title "Do Antifibrinolytics Reduce Allogeneic Blood Transfusion in Orthopedic Surgery?" @default.
- W2100730818 cites W115850590 @default.
- W2100730818 cites W1263479388 @default.
- W2100730818 cites W1522868684 @default.
- W2100730818 cites W179173062 @default.
- W2100730818 cites W183199475 @default.
- W2100730818 cites W1840647188 @default.
- W2100730818 cites W1903132268 @default.
- W2100730818 cites W1936462000 @default.
- W2100730818 cites W1966916788 @default.
- W2100730818 cites W1968167461 @default.
- W2100730818 cites W1970715117 @default.
- W2100730818 cites W1973926878 @default.
- W2100730818 cites W1980140122 @default.
- W2100730818 cites W1989827777 @default.
- W2100730818 cites W1990694409 @default.
- W2100730818 cites W1993824807 @default.
- W2100730818 cites W1999246075 @default.
- W2100730818 cites W2001110165 @default.
- W2100730818 cites W2001354725 @default.
- W2100730818 cites W2001486747 @default.
- W2100730818 cites W2004065438 @default.
- W2100730818 cites W2007270179 @default.
- W2100730818 cites W2007612411 @default.
- W2100730818 cites W2010243313 @default.
- W2100730818 cites W2014366523 @default.
- W2100730818 cites W2014709945 @default.
- W2100730818 cites W2020155225 @default.
- W2100730818 cites W2023617518 @default.
- W2100730818 cites W2024163818 @default.
- W2100730818 cites W2025793149 @default.
- W2100730818 cites W2026060506 @default.
- W2100730818 cites W2027472385 @default.
- W2100730818 cites W2033352183 @default.
- W2100730818 cites W2033890227 @default.
- W2100730818 cites W2042878569 @default.
- W2100730818 cites W2058651635 @default.
- W2100730818 cites W2059989187 @default.
- W2100730818 cites W2065045390 @default.
- W2100730818 cites W2075039980 @default.
- W2100730818 cites W2075787712 @default.
- W2100730818 cites W2077421021 @default.
- W2100730818 cites W2081526600 @default.
- W2100730818 cites W2090021216 @default.
- W2100730818 cites W2095221861 @default.
- W2100730818 cites W2096459479 @default.
- W2100730818 cites W2098686310 @default.
- W2100730818 cites W2099751180 @default.
- W2100730818 cites W2113341422 @default.
- W2100730818 cites W2117497154 @default.
- W2100730818 cites W2125864132 @default.
- W2100730818 cites W2128279895 @default.
- W2100730818 cites W2128373624 @default.
- W2100730818 cites W2150085168 @default.
- W2100730818 cites W2155582396 @default.
- W2100730818 cites W2156515605 @default.
- W2100730818 cites W2158949340 @default.
- W2100730818 cites W2159805045 @default.
- W2100730818 cites W2168513960 @default.
- W2100730818 cites W2174850754 @default.
- W2100730818 cites W2294956134 @default.
- W2100730818 cites W2401450227 @default.
- W2100730818 cites W2403967260 @default.
- W2100730818 cites W2404359169 @default.
- W2100730818 cites W2409004376 @default.
- W2100730818 cites W2418114756 @default.
- W2100730818 cites W2429049059 @default.
- W2100730818 cites W2792510538 @default.
- W2100730818 cites W44985736 @default.
- W2100730818 cites W63395447 @default.
- W2100730818 doi "https://doi.org/10.1097/00000542-200611000-00026" @default.
- W2100730818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17065899" @default.
- W2100730818 hasPublicationYear "2006" @default.
- W2100730818 type Work @default.
- W2100730818 sameAs 2100730818 @default.
- W2100730818 citedByCount "314" @default.
- W2100730818 countsByYear W21007308182012 @default.
- W2100730818 countsByYear W21007308182013 @default.
- W2100730818 countsByYear W21007308182014 @default.
- W2100730818 countsByYear W21007308182015 @default.
- W2100730818 countsByYear W21007308182016 @default.
- W2100730818 countsByYear W21007308182017 @default.
- W2100730818 countsByYear W21007308182018 @default.
- W2100730818 countsByYear W21007308182019 @default.
- W2100730818 countsByYear W21007308182020 @default.
- W2100730818 countsByYear W21007308182021 @default.