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- W2100741512 abstract "High molecular group box 1 (HMGB1) is a highly conserved member of the HMG-box-family; abundantly expressed in almost all human cells and released in apoptosis; necrosis or by activated immune cells. Once in the extracellular space, HMGB1 can act as a danger associated molecular pattern (DAMP), thus stimulating or inhibiting certain functions of the immune system; depending on the combinatorial cocktail of the surrounding milieu. HMGB1 exerts its various functions through binding to a multitude of membrane-bound receptors such as TLR-2; -4 and -9; IL-1 and RAGE (receptor for advanced glycation end products); partly complex-bound with intracellular fragments like nucleosomes. Soluble RAGE in the extracellular space, however, acts as a decoy receptor by binding to HMGB1 and inhibiting its effects. This review aims to outline today's knowledge of structure, intra- and extracellular functions including mechanisms of release and finally the clinical relevance of HMGB1 and RAGE as clinical biomarkers in therapy monitoring, prediction and prognosis of malignant and autoimmune disease." @default.
- W2100741512 created "2016-06-24" @default.
- W2100741512 creator A5014457702 @default.
- W2100741512 creator A5077502588 @default.
- W2100741512 date "2015-06-16" @default.
- W2100741512 modified "2023-10-17" @default.
- W2100741512 title "Circulating HMGB1 and RAGE as Clinical Biomarkers in Malignant and Autoimmune Diseases" @default.
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