FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100745369> ?p ?o ?g. }

• W2100745369 endingPage "1005" @default.
• W2100745369 startingPage "996" @default.
• W2100745369 abstract "Bladder exstrophy–epispadias complex (BEEC) is a complex and debilitating congenital disease. Familial and twin studies suggest a possible genetic component in BEEC pathogenesis. Bladder mesenchyme (detrusor) development requires induction by a signal from bladder urothelium, and we and others have shown the Shh–Gli–Bmp4 signalling pathway is likely to be involved. P63 is a master regulator in epithelial stratification and is expressed in urothelium. We have shown that p63 knock-out mice undergo excessive urothelial apoptosis. Failure of mesenchymal induction by epithelium leads to BEEC. We further demonstrated that insertion/deletion (in/del) polymorphisms (1 base pair (bp) ins and 4 bp ins., and 12 bp del) in the ΔNP63 promoter reduce transcriptional efficiency, and are associated with a statistically significant increase in the risk of BEEC in humans. Furthermore, a Genome-Wide Expression Profiling (GWEP) study suggests possible involvement of PERP in human BEEC. Intriguingly, PERP is a direct target of p63 during development, and is also involved in epithelial stratification. PERP co-localizes with desmosome, and both PERP and desmosome are essential for maintaining tissue integrity by cellular adhesion and epithelial stratification. A recent study showed that PERP and desmosome expression levels are abnormal in human BEEC patients. This review describes the role of the P63 > PERP > desmosome pathway in the development of human bladder during embryogenesis. We hypothesize that disruption of this pathway may increase the risk of BEEC." @default.
• W2100745369 created "2016-06-24" @default.
• W2100745369 creator A5015773853 @default.
• W2100745369 creator A5025603599 @default.
• W2100745369 creator A5026571233 @default.
• W2100745369 creator A5079884952 @default.
• W2100745369 creator A5086102745 @default.
• W2100745369 date "2013-12-01" @default.
• W2100745369 modified "2023-10-16" @default.
• W2100745369 title "New insights into the pathogenesis of bladder exstrophy–epispadias complex" @default.
• W2100745369 cites W1482923899 @default.
• W2100745369 cites W1499356459 @default.
• W2100745369 cites W1532880128 @default.
• W2100745369 cites W1534987406 @default.
• W2100745369 cites W1536062637 @default.
• W2100745369 cites W1566822031 @default.
• W2100745369 cites W1770349940 @default.
• W2100745369 cites W1965906405 @default.
• W2100745369 cites W1966029868 @default.
• W2100745369 cites W1966030396 @default.
• W2100745369 cites W1966973741 @default.
• W2100745369 cites W1969369383 @default.
• W2100745369 cites W1972005307 @default.
• W2100745369 cites W1973649758 @default.
• W2100745369 cites W1974712344 @default.
• W2100745369 cites W1978849284 @default.
• W2100745369 cites W1978939359 @default.
• W2100745369 cites W1987216586 @default.
• W2100745369 cites W1987295667 @default.
• W2100745369 cites W1989190896 @default.
• W2100745369 cites W1993423102 @default.
• W2100745369 cites W1994656123 @default.
• W2100745369 cites W1996338619 @default.
• W2100745369 cites W1997758723 @default.
• W2100745369 cites W2003576975 @default.
• W2100745369 cites W2004374245 @default.
• W2100745369 cites W2010807493 @default.
• W2100745369 cites W2010967592 @default.
• W2100745369 cites W2012170802 @default.
• W2100745369 cites W2014938226 @default.
• W2100745369 cites W2017019345 @default.
• W2100745369 cites W2020744720 @default.
• W2100745369 cites W2021736358 @default.
• W2100745369 cites W2026980031 @default.
• W2100745369 cites W2029341916 @default.
• W2100745369 cites W2033367375 @default.
• W2100745369 cites W2034477244 @default.
• W2100745369 cites W2034597460 @default.
• W2100745369 cites W2038425676 @default.
• W2100745369 cites W2047683729 @default.
• W2100745369 cites W2049342116 @default.
• W2100745369 cites W2053693231 @default.
• W2100745369 cites W2054052732 @default.
• W2100745369 cites W2059273411 @default.
• W2100745369 cites W2059291562 @default.
• W2100745369 cites W2060823106 @default.
• W2100745369 cites W2062047607 @default.
• W2100745369 cites W2066474485 @default.
• W2100745369 cites W2071352756 @default.
• W2100745369 cites W2071497196 @default.
• W2100745369 cites W2073026991 @default.
• W2100745369 cites W2074969215 @default.
• W2100745369 cites W2076747194 @default.
• W2100745369 cites W2077480017 @default.
• W2100745369 cites W2078131185 @default.
• W2100745369 cites W2079035766 @default.
• W2100745369 cites W2082720202 @default.
• W2100745369 cites W2083291607 @default.
• W2100745369 cites W2085849518 @default.
• W2100745369 cites W2089061164 @default.
• W2100745369 cites W2091526089 @default.
• W2100745369 cites W2093857618 @default.
• W2100745369 cites W2093859970 @default.
• W2100745369 cites W2095424453 @default.
• W2100745369 cites W2097292884 @default.
• W2100745369 cites W2098850858 @default.
• W2100745369 cites W2111513766 @default.
• W2100745369 cites W2112881364 @default.
• W2100745369 cites W2113945666 @default.
• W2100745369 cites W2118849350 @default.
• W2100745369 cites W2118970774 @default.
• W2100745369 cites W2119284420 @default.
• W2100745369 cites W2122152554 @default.
• W2100745369 cites W2125538479 @default.
• W2100745369 cites W2125878895 @default.
• W2100745369 cites W2126018490 @default.
• W2100745369 cites W2126259239 @default.
• W2100745369 cites W2131736369 @default.
• W2100745369 cites W2133691034 @default.
• W2100745369 cites W2136757828 @default.
• W2100745369 cites W2137588974 @default.
• W2100745369 cites W2138517767 @default.
• W2100745369 cites W2138663989 @default.
• W2100745369 cites W2143429705 @default.
• W2100745369 cites W2143987907 @default.
• W2100745369 cites W2149214251 @default.
• W2100745369 cites W2150104849 @default.
• W2100745369 cites W2151322467 @default.

• next