FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100748279> ?p ?o ?g. }

• W2100748279 endingPage "30" @default.
• W2100748279 startingPage "25" @default.
• W2100748279 abstract "Xenopus laevis RNA‐binding protein A (Xlrbpa) is a highly conserved, ubiquitously expressed hnRNP‐ and ribosome‐associated RNA‐binding protein that contains three double stranded RNA‐binding domains (dsRBDs) in tandem arrangement. A two‐hybrid screen with Xlrbpa as a bait recovered Xlrbpa itself as the strongest interaction partner, indicating multimerization of this protein. To search for regions responsible for the observed interaction, we conducted two‐hybrid assays with Xlrbpa deletion constructs and identified the third dsRBD of Xlrbpa as the exclusive interacting domain. Additionally, these results were confirmed by coimmunoprecipitation experiments with truncated proteins expressed both in yeast and Xenopus oocytes. In PACT, the human homologue of Xlrbpa, we could demonstrate that the third dsRBD displays the same multimerization activity. Interestingly, this domain is essential for the activation of the dsRNA‐activated protein kinase PKR. Addition of RNAses to coimmunoprecipitation experiments did not affect the dimerization, suggesting that the interaction is independent of RNA‐binding. We report here a homomultimerization activity of a type B dsRBD and suggest possible implications that include a model for PKR activation by PACT." @default.
• W2100748279 created "2016-06-24" @default.
• W2100748279 creator A5013101153 @default.
• W2100748279 creator A5019058171 @default.
• W2100748279 creator A5044406268 @default.
• W2100748279 creator A5091000347 @default.
• W2100748279 date "2004-08-11" @default.
• W2100748279 modified "2023-10-17" @default.
• W2100748279 title "Oligomerization activity of a double-stranded RNA-binding domain" @default.
• W2100748279 cites W123685430 @default.
• W2100748279 cites W1585686118 @default.
• W2100748279 cites W1826524642 @default.
• W2100748279 cites W1843804635 @default.
• W2100748279 cites W1871011319 @default.
• W2100748279 cites W1909944883 @default.
• W2100748279 cites W1963661027 @default.
• W2100748279 cites W1964173713 @default.
• W2100748279 cites W1965439215 @default.
• W2100748279 cites W1978340521 @default.
• W2100748279 cites W1990713365 @default.
• W2100748279 cites W2001464207 @default.
• W2100748279 cites W2003725405 @default.
• W2100748279 cites W2007699219 @default.
• W2100748279 cites W2013219100 @default.
• W2100748279 cites W2019736486 @default.
• W2100748279 cites W2021295271 @default.
• W2100748279 cites W2029842408 @default.
• W2100748279 cites W2038312393 @default.
• W2100748279 cites W2038652232 @default.
• W2100748279 cites W2042159800 @default.
• W2100748279 cites W2061420374 @default.
• W2100748279 cites W2063954657 @default.
• W2100748279 cites W2066987191 @default.
• W2100748279 cites W2068803943 @default.
• W2100748279 cites W2074168438 @default.
• W2100748279 cites W2077808289 @default.
• W2100748279 cites W2082070254 @default.
• W2100748279 cites W2087576311 @default.
• W2100748279 cites W2089402352 @default.
• W2100748279 cites W2097296383 @default.
• W2100748279 cites W2098440166 @default.
• W2100748279 cites W2118331214 @default.
• W2100748279 cites W2118635464 @default.
• W2100748279 cites W2128674562 @default.
• W2100748279 cites W2134016462 @default.
• W2100748279 cites W2135429740 @default.
• W2100748279 cites W2152889183 @default.
• W2100748279 cites W2334137373 @default.
• W2100748279 cites W96913086 @default.
• W2100748279 doi "https://doi.org/10.1016/j.febslet.2004.07.080" @default.
• W2100748279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15358534" @default.
• W2100748279 hasPublicationYear "2004" @default.
• W2100748279 type Work @default.
• W2100748279 sameAs 2100748279 @default.
• W2100748279 citedByCount "38" @default.
• W2100748279 countsByYear W21007482792012 @default.
• W2100748279 countsByYear W21007482792013 @default.
• W2100748279 countsByYear W21007482792014 @default.
• W2100748279 countsByYear W21007482792016 @default.
• W2100748279 countsByYear W21007482792017 @default.
• W2100748279 countsByYear W21007482792018 @default.
• W2100748279 countsByYear W21007482792019 @default.
• W2100748279 countsByYear W21007482792021 @default.
• W2100748279 countsByYear W21007482792022 @default.
• W2100748279 crossrefType "journal-article" @default.
• W2100748279 hasAuthorship W2100748279A5013101153 @default.
• W2100748279 hasAuthorship W2100748279A5019058171 @default.
• W2100748279 hasAuthorship W2100748279A5044406268 @default.
• W2100748279 hasAuthorship W2100748279A5091000347 @default.
• W2100748279 hasConcept C104317684 @default.
• W2100748279 hasConcept C107824862 @default.
• W2100748279 hasConcept C153911025 @default.
• W2100748279 hasConcept C185592680 @default.
• W2100748279 hasConcept C2779535977 @default.
• W2100748279 hasConcept C41282012 @default.
• W2100748279 hasConcept C51639874 @default.
• W2100748279 hasConcept C55493867 @default.
• W2100748279 hasConcept C67705224 @default.
• W2100748279 hasConcept C71829478 @default.
• W2100748279 hasConcept C86803240 @default.
• W2100748279 hasConcept C95444343 @default.
• W2100748279 hasConceptScore W2100748279C104317684 @default.
• W2100748279 hasConceptScore W2100748279C107824862 @default.
• W2100748279 hasConceptScore W2100748279C153911025 @default.
• W2100748279 hasConceptScore W2100748279C185592680 @default.
• W2100748279 hasConceptScore W2100748279C2779535977 @default.
• W2100748279 hasConceptScore W2100748279C41282012 @default.
• W2100748279 hasConceptScore W2100748279C51639874 @default.
• W2100748279 hasConceptScore W2100748279C55493867 @default.
• W2100748279 hasConceptScore W2100748279C67705224 @default.
• W2100748279 hasConceptScore W2100748279C71829478 @default.
• W2100748279 hasConceptScore W2100748279C86803240 @default.
• W2100748279 hasConceptScore W2100748279C95444343 @default.
• W2100748279 hasIssue "1-3" @default.
• W2100748279 hasLocation W21007482791 @default.
• W2100748279 hasLocation W21007482792 @default.
• W2100748279 hasOpenAccess W2100748279 @default.
• W2100748279 hasPrimaryLocation W21007482791 @default.

• next