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• W2100761505 abstract "Traditional medicine in South Africa is part of the culture of the people and has been in existence for a long-time. Although animal components form part of the ingredients used, plant material constitutes the major component. South Africa is endowed with vast resources of medicinal and aromatic plants which have been employed for treatment against various diseases for decades. A large number of South Africans still depend on traditional medicine for their healthcare needs due to its affordability, accessibility and cultural importance. Helminth infections are among the variety of diseases treated by traditional healers. These infections are regarded as neglected tropical diseases (NTDs) due to their high prevalence among the economically disadvantaged living in rural areas in different regions of the world. For this study, eleven plants from nine families were selected based on their ethnopharmacological uses as anthelmintics. To validate the efficacy of the plants and for possible discovery of bioactive chemicals, it was deemed important to pharmacologically investigate the selected plants. Besides anthelmintic testing, antimicrobial activity and cyclooxygenase (COX) inhibitory activity screening of the plants were also carried out because microbial infections and inflammation are often associated with helminth infections. The plants investigated were also subjected to phytochemical analysis to test for the presence of different secondary metabolites that could be responsible for the biological activities observed. The plant materials were collected in KwaZulu-Natal between February and April 2009. Plant parts used in traditional medicine were collected and for sustainable harvesting of medicinal plants in order to enhance conservation, alternative plant parts (leaves and twigs) of some of the plants were also investigated. Independently, the plant material was extracted using petroleum ether (PE), dichloromethane (DCM), ethanol (EtOH) and water. A total of 80 extracts were prepared from the selected plants which were screened for anthelmintic, antimicrobial and COX inhibitory activities. For the phytochemical analysis, 50% aqueous methanol (MeOH) extracts were used to determine the presence of phenolics and alkaloids, while water" @default.
• W2100761505 created "2016-06-24" @default.
• W2100761505 creator A5022694953 @default.
• W2100761505 date "2009-01-01" @default.
• W2100761505 modified "2023-09-27" @default.
• W2100761505 title "Pharmacology and phytochemistry of South African plants used as anthelmintics." @default.
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