FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100764580> ?p ?o ?g. }

• W2100764580 endingPage "2102" @default.
• W2100764580 startingPage "2093" @default.
• W2100764580 abstract "Digoxin, an orally administered cardiac glycoside cardiovascular drug, has a narrow therapeutic window. Circulating digoxin levels (maximal concentration of ∼1.5 ng/ml) require careful monitoring, and the potential for drug-drug interactions (DDI) is a concern. Increases in digoxin plasma exposure caused by inhibition of P-glycoprotein (P-gp) have been reported. Digoxin has also been described as a substrate of various organic anion-transporting polypeptide (OATP) transporters, posing a risk that inhibition of OATPs may result in a clinically relevant DDI similar to what has been observed for P-gp. Although studies in rats have shown that Oatps contribute to the disposition of digoxin, the role of OATPs in the disposition of digoxin in humans has not been clearly defined. Using two methods, Boehringer Ingelheim, GlaxoSmithKline, Pfizer, and Solvo observed that digoxin is not a substrate of OATP1A2, OATP1B1, OATP1B3, and OATP2B1. However, digoxin inhibited the uptake of probe substrates of OATP1B1 (IC₅₀ of 47 μM), OATP1B3 (IC₅₀ > 8.1 μM), and OATP2B1 (IC₅₀ > 300 μM), but not OATP1A2 in transfected cell lines. It is interesting to note that digoxin is a substrate of a sodium-dependent transporter endogenously expressed in HEK293 cells because uptake of digoxin was significantly greater in cells incubated with sodium-fortified media compared with incubations conducted in media in which sodium was absent. Thus, although digoxin is not a substrate for the human OATP transporters evaluated in this study, in addition to P-gp-mediated efflux, its uptake and pharmacokinetic disposition may be partially facilitated by a sodium-dependent transporter." @default.
• W2100764580 created "2016-06-24" @default.
• W2100764580 creator A5002567396 @default.
• W2100764580 creator A5007497847 @default.
• W2100764580 creator A5024576356 @default.
• W2100764580 creator A5039876591 @default.
• W2100764580 creator A5049285430 @default.
• W2100764580 creator A5050034362 @default.
• W2100764580 creator A5054230253 @default.
• W2100764580 creator A5058921891 @default.
• W2100764580 creator A5059608065 @default.
• W2100764580 creator A5061422874 @default.
• W2100764580 date "2011-08-17" @default.
• W2100764580 modified "2023-10-17" @default.
• W2100764580 title "Digoxin Is Not a Substrate for Organic Anion-Transporting Polypeptide Transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but Is a Substrate for a Sodium-Dependent Transporter Expressed in HEK293 Cells" @default.
• W2100764580 cites W1978825558 @default.
• W2100764580 cites W2000440671 @default.
• W2100764580 cites W2000478673 @default.
• W2100764580 cites W2002119441 @default.
• W2100764580 cites W2005624606 @default.
• W2100764580 cites W2006807155 @default.
• W2100764580 cites W2011548686 @default.
• W2100764580 cites W2011761170 @default.
• W2100764580 cites W2031595392 @default.
• W2100764580 cites W2035386539 @default.
• W2100764580 cites W2040539069 @default.
• W2100764580 cites W2045948705 @default.
• W2100764580 cites W2050815455 @default.
• W2100764580 cites W2053613516 @default.
• W2100764580 cites W2056514126 @default.
• W2100764580 cites W2066438436 @default.
• W2100764580 cites W2067737110 @default.
• W2100764580 cites W2070410120 @default.
• W2100764580 cites W2082627462 @default.
• W2100764580 cites W2083212229 @default.
• W2100764580 cites W2084418363 @default.
• W2100764580 cites W2091555698 @default.
• W2100764580 cites W2094110689 @default.
• W2100764580 cites W2135947657 @default.
• W2100764580 cites W2140065347 @default.
• W2100764580 cites W2147787974 @default.
• W2100764580 cites W2156270847 @default.
• W2100764580 cites W2161215121 @default.
• W2100764580 cites W2315418372 @default.
• W2100764580 cites W2764148593 @default.
• W2100764580 doi "https://doi.org/10.1124/dmd.111.040816" @default.
• W2100764580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21849517" @default.
• W2100764580 hasPublicationYear "2011" @default.
• W2100764580 type Work @default.
• W2100764580 sameAs 2100764580 @default.
• W2100764580 citedByCount "60" @default.
• W2100764580 countsByYear W21007645802012 @default.
• W2100764580 countsByYear W21007645802013 @default.
• W2100764580 countsByYear W21007645802014 @default.
• W2100764580 countsByYear W21007645802015 @default.
• W2100764580 countsByYear W21007645802016 @default.
• W2100764580 countsByYear W21007645802017 @default.
• W2100764580 countsByYear W21007645802018 @default.
• W2100764580 countsByYear W21007645802019 @default.
• W2100764580 countsByYear W21007645802020 @default.
• W2100764580 countsByYear W21007645802021 @default.
• W2100764580 countsByYear W21007645802022 @default.
• W2100764580 crossrefType "journal-article" @default.
• W2100764580 hasAuthorship W2100764580A5002567396 @default.
• W2100764580 hasAuthorship W2100764580A5007497847 @default.
• W2100764580 hasAuthorship W2100764580A5024576356 @default.
• W2100764580 hasAuthorship W2100764580A5039876591 @default.
• W2100764580 hasAuthorship W2100764580A5049285430 @default.
• W2100764580 hasAuthorship W2100764580A5050034362 @default.
• W2100764580 hasAuthorship W2100764580A5054230253 @default.
• W2100764580 hasAuthorship W2100764580A5058921891 @default.
• W2100764580 hasAuthorship W2100764580A5059608065 @default.
• W2100764580 hasAuthorship W2100764580A5061422874 @default.
• W2100764580 hasConcept C104317684 @default.
• W2100764580 hasConcept C123584848 @default.
• W2100764580 hasConcept C126322002 @default.
• W2100764580 hasConcept C133936738 @default.
• W2100764580 hasConcept C149011108 @default.
• W2100764580 hasConcept C170493617 @default.
• W2100764580 hasConcept C174510640 @default.
• W2100764580 hasConcept C178790620 @default.
• W2100764580 hasConcept C185592680 @default.
• W2100764580 hasConcept C18903297 @default.
• W2100764580 hasConcept C200082930 @default.
• W2100764580 hasConcept C2776678969 @default.
• W2100764580 hasConcept C2777289219 @default.
• W2100764580 hasConcept C2777707475 @default.
• W2100764580 hasConcept C2778198053 @default.
• W2100764580 hasConcept C2778707650 @default.
• W2100764580 hasConcept C2779133857 @default.
• W2100764580 hasConcept C2780557390 @default.
• W2100764580 hasConcept C501593827 @default.
• W2100764580 hasConcept C537181965 @default.
• W2100764580 hasConcept C55493867 @default.
• W2100764580 hasConcept C71924100 @default.
• W2100764580 hasConcept C86803240 @default.
• W2100764580 hasConcept C98274493 @default.
• W2100764580 hasConceptScore W2100764580C104317684 @default.

• next