FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100768460> ?p ?o ?g. }

• W2100768460 abstract "Understanding the aspects of the cell functionality that account for disease or drug action mechanisms is one of the main challenges in the analysis of genomic data and is on the basis of the future implementation of precision medicine.Here we propose a simple probabilistic model in which signaling pathways are separated into elementary sub-pathways or signal transmission circuits (which ultimately trigger cell functions) and then transforms gene expression measurements into probabilities of activation of such signal transmission circuits. Using this model, differential activation of such circuits between biological conditions can be estimated. Thus, circuit activation statuses can be interpreted as biomarkers that discriminate among the compared conditions. This type of mechanism-based biomarkers accounts for cell functional activities and can easily be associated to disease or drug action mechanisms. The accuracy of the proposed model is demonstrated with simulations and real datasets.The proposed model provides detailed information that enables the interpretation disease mechanisms as a consequence of the complex combinations of altered gene expression values. Moreover, it offers a framework for suggesting possible ways of therapeutic intervention in a pathologically perturbed system." @default.
• W2100768460 created "2016-06-24" @default.
• W2100768460 creator A5002377126 @default.
• W2100768460 creator A5014810730 @default.
• W2100768460 creator A5018017520 @default.
• W2100768460 creator A5025099930 @default.
• W2100768460 creator A5028520416 @default.
• W2100768460 creator A5044524656 @default.
• W2100768460 creator A5069805911 @default.
• W2100768460 creator A5073107684 @default.
• W2100768460 creator A5074140420 @default.
• W2100768460 creator A5079179603 @default.
• W2100768460 creator A5091413224 @default.
• W2100768460 date "2014-10-25" @default.
• W2100768460 modified "2023-10-18" @default.
• W2100768460 title "Understanding disease mechanisms with models of signaling pathway activities" @default.
• W2100768460 cites W1546952499 @default.
• W2100768460 cites W1552069634 @default.
• W2100768460 cites W1690786713 @default.
• W2100768460 cites W1971224531 @default.
• W2100768460 cites W1981509058 @default.
• W2100768460 cites W1984225101 @default.
• W2100768460 cites W1990144966 @default.
• W2100768460 cites W1991980854 @default.
• W2100768460 cites W1992045522 @default.
• W2100768460 cites W1993346355 @default.
• W2100768460 cites W1998767819 @default.
• W2100768460 cites W2004170013 @default.
• W2100768460 cites W2006540875 @default.
• W2100768460 cites W2007012192 @default.
• W2100768460 cites W2009405916 @default.
• W2100768460 cites W2013318867 @default.
• W2100768460 cites W2013522363 @default.
• W2100768460 cites W2015291385 @default.
• W2100768460 cites W2015401980 @default.
• W2100768460 cites W2016121266 @default.
• W2100768460 cites W2017568254 @default.
• W2100768460 cites W2021560851 @default.
• W2100768460 cites W2022406334 @default.
• W2100768460 cites W2026341138 @default.
• W2100768460 cites W2028815852 @default.
• W2100768460 cites W2032712154 @default.
• W2100768460 cites W2036055444 @default.
• W2100768460 cites W2037231042 @default.
• W2100768460 cites W2047031939 @default.
• W2100768460 cites W2049527386 @default.
• W2100768460 cites W2054892633 @default.
• W2100768460 cites W2055611673 @default.
• W2100768460 cites W2056944294 @default.
• W2100768460 cites W2058221907 @default.
• W2100768460 cites W2062533676 @default.
• W2100768460 cites W2074746593 @default.
• W2100768460 cites W2075602427 @default.
• W2100768460 cites W2080218141 @default.
• W2100768460 cites W2082026429 @default.
• W2100768460 cites W2082081674 @default.
• W2100768460 cites W2084533385 @default.
• W2100768460 cites W2089390825 @default.
• W2100768460 cites W2091209259 @default.
• W2100768460 cites W2091841926 @default.
• W2100768460 cites W2092113847 @default.
• W2100768460 cites W2095701698 @default.
• W2100768460 cites W2100980426 @default.
• W2100768460 cites W2102140960 @default.
• W2100768460 cites W2102944675 @default.
• W2100768460 cites W2103017472 @default.
• W2100768460 cites W2106248311 @default.
• W2100768460 cites W2109431580 @default.
• W2100768460 cites W2109864332 @default.
• W2100768460 cites W2110318292 @default.
• W2100768460 cites W2110687686 @default.
• W2100768460 cites W2113764711 @default.
• W2100768460 cites W2119423220 @default.
• W2100768460 cites W2119454933 @default.
• W2100768460 cites W2121126239 @default.
• W2100768460 cites W2122683221 @default.
• W2100768460 cites W2123106337 @default.
• W2100768460 cites W2123724449 @default.
• W2100768460 cites W2124388496 @default.
• W2100768460 cites W2124599018 @default.
• W2100768460 cites W2126086567 @default.
• W2100768460 cites W2127401140 @default.
• W2100768460 cites W2131989143 @default.
• W2100768460 cites W2132992030 @default.
• W2100768460 cites W2133465414 @default.
• W2100768460 cites W2134736660 @default.
• W2100768460 cites W2135230352 @default.
• W2100768460 cites W2139703939 @default.
• W2100768460 cites W2141703917 @default.
• W2100768460 cites W2145899141 @default.
• W2100768460 cites W2146995322 @default.
• W2100768460 cites W2147056998 @default.
• W2100768460 cites W2149060064 @default.
• W2100768460 cites W2151852639 @default.
• W2100768460 cites W2153795693 @default.
• W2100768460 cites W2154362705 @default.
• W2100768460 cites W2154972152 @default.
• W2100768460 cites W2155581408 @default.
• W2100768460 cites W2157769714 @default.
• W2100768460 cites W2159841585 @default.

• next