FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100791808> ?p ?o ?g. }

• W2100791808 endingPage "1994" @default.
• W2100791808 startingPage "1987" @default.
• W2100791808 abstract "Abstract While an elevated plasma concentration of HDLs is protective against the development of atherosclerosis and ensuing coronary heart disease (CHD), the mechanism of this protection is unknown. One early cellular event in atherogenesis is the adhesion of mononuclear leukocytes to the endothelium. This event is mediated principally by vascular cell adhesion molecule-1 (VCAM-1) but also involves other molecules, such as intercellular adhesion molecule-1 (ICAM-1) and E-selectin. We have investigated the effect of isolated plasma HDLs and reconstituted HDLs on the expression of these molecules by endothelial cells. We show that physiological concentrations of HDLs inhibit tumor necrosis factor-α (TNF-α) or interleukin-1 (IL-1) induction of these leukocyte adhesion molecules in a concentration-dependent manner. Steady state mRNA levels of TNF-α–induced VCAM-1 and E-selectin are significantly reduced by physiological concentrations of HDLs. At an HDL concentration of 1 mg/mL apolipoprotein A-I, the protein expressions of VCAM-1, ICAM-1, and E-selectin were inhibited by 89.6±0.4% (mean±SD, n=4), 64.8±1.0%, and 79.2±0.4%, respectively. In contrast, HDLs have no effect on the expression of platelet endothelial cell adhesion molecule (PECAM) or on the expression of the p55 and p75 subunits of the TNF-α receptor. HDLs were effective when added from 16 hours before to 5 minutes after cytokine stimulation. HDLs had no effect on TNF-α–induced expression of ICAM-1 by human foreskin fibroblasts, suggesting that the effect is cell-type restricted. This study provides the first evidence that HDLs may protect against CHD by inhibiting the expression of adhesion molecules, which are required for the interaction between leukocytes and the endothelium." @default.
• W2100791808 created "2016-06-24" @default.
• W2100791808 creator A5013655811 @default.
• W2100791808 creator A5023996863 @default.
• W2100791808 creator A5049081447 @default.
• W2100791808 creator A5049478097 @default.
• W2100791808 creator A5089774496 @default.
• W2100791808 date "1995-11-01" @default.
• W2100791808 modified "2023-10-14" @default.
• W2100791808 title "High-Density Lipoproteins Inhibit Cytokine-Induced Expression of Endothelial Cell Adhesion Molecules" @default.
• W2100791808 cites W1559848422 @default.
• W2100791808 cites W1564398150 @default.
• W2100791808 cites W1574745553 @default.
• W2100791808 cites W1578438134 @default.
• W2100791808 cites W1809540926 @default.
• W2100791808 cites W1857052429 @default.
• W2100791808 cites W2001720727 @default.
• W2100791808 cites W2016112964 @default.
• W2100791808 cites W2020361370 @default.
• W2100791808 cites W2026075546 @default.
• W2100791808 cites W2029157767 @default.
• W2100791808 cites W2029294756 @default.
• W2100791808 cites W2037150903 @default.
• W2100791808 cites W2050795431 @default.
• W2100791808 cites W2057905142 @default.
• W2100791808 cites W2062144288 @default.
• W2100791808 cites W2064626913 @default.
• W2100791808 cites W2064861744 @default.
• W2100791808 cites W2068385369 @default.
• W2100791808 cites W2083217753 @default.
• W2100791808 cites W2094768566 @default.
• W2100791808 cites W2097103756 @default.
• W2100791808 cites W2099992849 @default.
• W2100791808 cites W2101216734 @default.
• W2100791808 cites W2105194226 @default.
• W2100791808 cites W2131222777 @default.
• W2100791808 cites W2132239020 @default.
• W2100791808 cites W2140402044 @default.
• W2100791808 cites W2153446844 @default.
• W2100791808 cites W2159401430 @default.
• W2100791808 cites W2161165626 @default.
• W2100791808 cites W2168878865 @default.
• W2100791808 cites W2576734941 @default.
• W2100791808 cites W4232909283 @default.
• W2100791808 cites W4244606416 @default.
• W2100791808 cites W4294216491 @default.
• W2100791808 cites W993790038 @default.
• W2100791808 doi "https://doi.org/10.1161/01.atv.15.11.1987" @default.
• W2100791808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7583580" @default.
• W2100791808 hasPublicationYear "1995" @default.
• W2100791808 type Work @default.
• W2100791808 sameAs 2100791808 @default.
• W2100791808 citedByCount "645" @default.
• W2100791808 countsByYear W21007918082012 @default.
• W2100791808 countsByYear W21007918082013 @default.
• W2100791808 countsByYear W21007918082014 @default.
• W2100791808 countsByYear W21007918082015 @default.
• W2100791808 countsByYear W21007918082016 @default.
• W2100791808 countsByYear W21007918082017 @default.
• W2100791808 countsByYear W21007918082018 @default.
• W2100791808 countsByYear W21007918082019 @default.
• W2100791808 countsByYear W21007918082020 @default.
• W2100791808 countsByYear W21007918082021 @default.
• W2100791808 countsByYear W21007918082022 @default.
• W2100791808 countsByYear W21007918082023 @default.
• W2100791808 crossrefType "journal-article" @default.
• W2100791808 hasAuthorship W2100791808A5013655811 @default.
• W2100791808 hasAuthorship W2100791808A5023996863 @default.
• W2100791808 hasAuthorship W2100791808A5049081447 @default.
• W2100791808 hasAuthorship W2100791808A5049478097 @default.
• W2100791808 hasAuthorship W2100791808A5089774496 @default.
• W2100791808 hasBestOaLocation W21007918081 @default.
• W2100791808 hasConcept C123012128 @default.
• W2100791808 hasConcept C134018914 @default.
• W2100791808 hasConcept C1491633281 @default.
• W2100791808 hasConcept C153911025 @default.
• W2100791808 hasConcept C16224149 @default.
• W2100791808 hasConcept C17991360 @default.
• W2100791808 hasConcept C185592680 @default.
• W2100791808 hasConcept C185946421 @default.
• W2100791808 hasConcept C199616788 @default.
• W2100791808 hasConcept C202751555 @default.
• W2100791808 hasConcept C203014093 @default.
• W2100791808 hasConcept C2776914184 @default.
• W2100791808 hasConcept C2776985958 @default.
• W2100791808 hasConcept C2776992346 @default.
• W2100791808 hasConcept C2778690821 @default.
• W2100791808 hasConcept C2909375385 @default.
• W2100791808 hasConcept C55493867 @default.
• W2100791808 hasConcept C85789140 @default.
• W2100791808 hasConcept C86803240 @default.
• W2100791808 hasConcept C95444343 @default.
• W2100791808 hasConceptScore W2100791808C123012128 @default.
• W2100791808 hasConceptScore W2100791808C134018914 @default.
• W2100791808 hasConceptScore W2100791808C1491633281 @default.
• W2100791808 hasConceptScore W2100791808C153911025 @default.
• W2100791808 hasConceptScore W2100791808C16224149 @default.
• W2100791808 hasConceptScore W2100791808C17991360 @default.

• next